SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 6 LYS A 294
VAL A 288
ILE A 292
MET A 179
 None
 1.01A 1iepA-4x8rA:
undetectable		 1iepA-4x8rA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 9 VAL A 237
LEU A 269
VAL A  40
GLY A  42
SER A 262
 None
 1.19A 1pxxB-4x8rA:
undetectable		 1pxxB-4x8rA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 10 VAL A 237
LEU A 269
VAL A  40
GLY A  42
SER A 262
 None
 1.21A 1pxxD-4x8rA:
undetectable		 1pxxD-4x8rA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 6 LYS A 294
VAL A 288
ILE A 292
MET A 179
 None
 0.97A 2hyyC-4x8rA:
undetectable		 2hyyC-4x8rA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		6 / 12 TYR A 308
ILE A 321
ALA A 100
ASN A  94
VAL A 174
PRO A  98
 None
 1.27A 2okcB-4x8rA:
undetectable		 2okcB-4x8rA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		3 / 3 PRO A 211
GLU A  41
TYR A  37
 None
 0.78A 2zmbA-4x8rA:
2.7		 2zmbA-4x8rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 6 LYS A 294
VAL A 288
ILE A 292
MET A 179
 None
 0.97A 3ms9A-4x8rA:
undetectable		 3ms9A-4x8rA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 5 THR A  78
ILE A  75
GLU A  71
PHE A 131
 None
None
BDP  A 401 (-2.7A)
None
 1.25A 4ac9C-4x8rA:
undetectable		 4ac9C-4x8rA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 5 THR A  78
ILE A  75
GLU A  71
PHE A 131
 None
None
BDP  A 401 (-2.7A)
None
 1.25A 4acaC-4x8rA:
undetectable		 4acaC-4x8rA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 5 THR A  78
ILE A  75
GLU A  71
PHE A 131
 None
None
BDP  A 401 (-2.7A)
None
 1.30A 4acbC-4x8rA:
undetectable		 4acbC-4x8rA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 237
LEU A 269
VAL A  40
GLY A  42
SER A 262
 None
 1.17A 4coxA-4x8rA:
undetectable		 4coxA-4x8rA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 6 GLU A 235
ARG A 147
GLU A  71
SER A  92
 BDP  A 401 (-2.9A)
BDP  A 401 (-3.0A)
BDP  A 401 (-2.7A)
BDP  A 401 ( 4.0A)
 1.20A 4kr3A-4x8rA:
2.6		 4kr3A-4x8rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 10 GLU A 207
ILE A 203
VAL A 194
ALA A 222
ILE A 198
 None
 1.07A 4lbgA-4x8rA:
undetectable		 4lbgA-4x8rA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 9 GLU A 207
ILE A 203
VAL A 194
ALA A 222
ILE A 198
 None
 0.91A 4lbgB-4x8rA:
undetectable		 4lbgB-4x8rA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 192
PHE A 131
PHE A  93
ILE A 137
THR A  78
 None
 1.27A 5fsaB-4x8rA:
undetectable		 5fsaB-4x8rA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 236
PRO A 234
GLU A 126
GLY A 124
SER A  89
 None
None
None
None
BDP  A 401 (-3.9A)
 1.14A 5o96A-4x8rA:
undetectable
5o96B-4x8rA:
undetectable		 5o96A-4x8rA:
23.03
5o96B-4x8rA:
23.03