SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4x8y MEMBRANE-ASSOCIATED
PROGESTERONE
RECEPTOR COMPONENT 1
(Homo
sapiens) 		3 / 3 ASP A 140
PHE A 116
ASN A  94
 None
 0.87A 1sg9B-4x8yA:
undetectable		 1sg9B-4x8yA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 4x8y MEMBRANE-ASSOCIATED
PROGESTERONE
RECEPTOR COMPONENT 1
(Homo
sapiens) 		5 / 11 LEU A 170
GLY A 118
ASP A  99
VAL A 167
VAL A  97
 None
 0.86A 1t7jA-4x8yA:
undetectable		 1t7jA-4x8yA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 4x8y MEMBRANE-ASSOCIATED
PROGESTERONE
RECEPTOR COMPONENT 1
(Homo
sapiens) 		5 / 12 LEU A 170
GLY A 118
ASP A  99
VAL A 167
VAL A  97
 None
 0.76A 3gguA-4x8yA:
undetectable		 3gguA-4x8yA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 4x8y MEMBRANE-ASSOCIATED
PROGESTERONE
RECEPTOR COMPONENT 1
(Homo
sapiens) 		5 / 10 LEU A 170
GLY A 118
ASP A  99
VAL A 167
VAL A  97
 None
 0.80A 3nu9B-4x8yA:
undetectable		 3nu9B-4x8yA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 4x8y MEMBRANE-ASSOCIATED
PROGESTERONE
RECEPTOR COMPONENT 1
(Homo
sapiens) 		3 / 3 PRO A 109
ARG A 104
GLU A 110
 None
 0.94A 5j6hA-4x8yA:
undetectable		 5j6hA-4x8yA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 4x8y MEMBRANE-ASSOCIATED
PROGESTERONE
RECEPTOR COMPONENT 1
(Homo
sapiens) 		5 / 12 LEU A 170
GLY A 118
ASP A  99
VAL A 167
VAL A  97
 None
 0.90A 6dh0A-4x8yA:
undetectable		 6dh0A-4x8yA:
17.89