SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x90'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 10 GLY A  12
SER A 165
MET A 166
THR A 329
HIS A 359
 None
MPD  A 409 (-3.5A)
None
None
None
 0.61A 1a8uA-4x90A:
13.3		 1a8uA-4x90A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 10 GLY A  12
SER A 165
MET A 166
THR A 329
HIS A 359
 None
MPD  A 409 (-3.5A)
None
None
None
 0.58A 1a8uB-4x90A:
13.0		 1a8uB-4x90A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 12 ILE A  61
ALA A 230
LEU A  14
ILE A 215
LEU A  49
 None
None
MPD  A 408 ( 4.6A)
MPD  A 411 (-3.8A)
None
 1.14A 1ddsB-4x90A:
undetectable		 1ddsB-4x90A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 12 ILE A  61
ALA A 230
LEU A  14
ILE A 215
LEU A  49
 None
None
MPD  A 408 ( 4.6A)
MPD  A 411 (-3.8A)
None
 1.07A 1dyiB-4x90A:
undetectable		 1dyiB-4x90A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 12 ILE A  61
ALA A 230
LEU A  14
ILE A 215
LEU A  49
 None
None
MPD  A 408 ( 4.6A)
MPD  A 411 (-3.8A)
None
 1.17A 1rx3A-4x90A:
undetectable		 1rx3A-4x90A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 12 ILE A  61
ALA A 230
LEU A  14
ILE A 215
LEU A  49
 None
None
MPD  A 408 ( 4.6A)
MPD  A 411 (-3.8A)
None
 0.98A 2d0kB-4x90A:
undetectable		 2d0kB-4x90A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 11 GLY A 167
PRO A  11
ASN A  16
VAL A  82
TYR A 128
 None
 1.27A 2fl5A-4x90A:
undetectable
2fl5B-4x90A:
undetectable
2fl5F-4x90A:
undetectable		 2fl5A-4x90A:
20.95
2fl5B-4x90A:
21.73
2fl5F-4x90A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		4 / 7 LEU A 144
LEU A 376
VAL A 159
LEU A 298
 None
 0.76A 3g8iA-4x90A:
undetectable		 3g8iA-4x90A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 199
PRO A 238
SER A 244
ALA A 335
 None
 1.19A 3i5uB-4x90A:
undetectable		 3i5uB-4x90A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		3 / 3 PRO A 319
PHE A 314
ALA A 208
 None
 0.68A 3itaD-4x90A:
undetectable		 3itaD-4x90A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		4 / 6 MET A 147
LEU A 144
PRO A  11
TYR A 140
 None
 1.42A 3vkxA-4x90A:
undetectable		 3vkxA-4x90A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 11 PRO A 196
SER A 165
GLN A 227
THR A 233
LEU A 236
 MPD  A 409 ( 4.7A)
MPD  A 409 (-3.5A)
MPD  A 408 ( 4.3A)
MPD  A 409 ( 4.7A)
MPD  A 409 (-4.8A)
 1.49A 3zqeA-4x90A:
undetectable
3zqeB-4x90A:
undetectable		 3zqeA-4x90A:
22.53
3zqeB-4x90A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		4 / 8 SER A 334
TYR A 173
ARG A 177
GLY A 283
 None
 0.94A 4fgzA-4x90A:
undetectable
4fgzB-4x90A:
undetectable		 4fgzA-4x90A:
18.27
4fgzB-4x90A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		4 / 8 SER A 334
GLY A 324
THR A 305
GLY A 300
 None
 0.83A 4fo4B-4x90A:
undetectable		 4fo4B-4x90A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 12 ILE A  61
ALA A 230
LEU A  14
ILE A 215
LEU A  49
 None
None
MPD  A 408 ( 4.6A)
MPD  A 411 (-3.8A)
None
 1.10A 4x5fA-4x90A:
undetectable		 4x5fA-4x90A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 12 ILE A  61
ALA A 230
LEU A  14
ILE A 215
LEU A  49
 None
None
MPD  A 408 ( 4.6A)
MPD  A 411 (-3.8A)
None
 1.09A 4x5fB-4x90A:
undetectable		 4x5fB-4x90A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 12 LEU A 363
TYR A 104
HIS A 164
LEU A 354
ASN A 168
 None
None
None
NAG  A 404 (-4.0A)
None
 1.37A 4yvxA-4x90A:
undetectable		 4yvxA-4x90A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 12 LEU A 363
TYR A 104
HIS A 164
LEU A 354
ASN A 168
 None
None
None
NAG  A 404 (-4.0A)
None
 1.32A 4yvxB-4x90A:
undetectable		 4yvxB-4x90A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		3 / 3 THR A 281
ALA A 133
ASN A 135
 None
 0.36A 5ersA-4x90A:
1.6		 5ersA-4x90A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		5 / 12 PRO A 290
HIS A 347
GLN A 345
ASP A 184
ALA A 181
 None
CL  A 406 ( 4.0A)
PO4  A 407 (-4.3A)
None
None
 1.48A 5zovB-4x90A:
undetectable		 5zovB-4x90A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens) 		6 / 12 HIS A 359
VAL A 303
ASP A 327
GLY A  12
SER A 165
VAL A 191
 None
None
None
None
MPD  A 409 (-3.5A)
None
 1.43A 6c2mC-4x90A:
undetectable		 6c2mC-4x90A:
12.53