SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x9f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9
(Drosophila
melanogaster) 		4 / 6 HIS A 186
LEU A 188
PHE A 134
VAL A 135
 None
 1.09A 1ibgH-4x9fA:
8.9		 1ibgH-4x9fA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9
(Drosophila
melanogaster) 		5 / 12 TYR A  80
LEU A  61
VAL A  75
ASP A  48
ARG A  40
 None
 0.93A 2qo4A-4x9fA:
undetectable		 2qo4A-4x9fA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9
(Drosophila
melanogaster) 		5 / 12 TYR A  80
LEU A  61
VAL A  75
ASP A  48
ARG A  40
 None
 0.92A 2qo6A-4x9fA:
undetectable		 2qo6A-4x9fA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9
(Drosophila
melanogaster) 		3 / 3 LYS A 219
PRO A 216
LYS A 213
 None
 1.31A 4duzL-4x9fA:
undetectable		 4duzL-4x9fA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9
(Drosophila
melanogaster) 		3 / 3 ARG A  94
GLU A 381
PHE A 372
 None
 1.01A 4kszA-4x9fA:
undetectable		 4kszA-4x9fA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9
(Drosophila
melanogaster) 		5 / 12 PHE A 245
SER A 244
VAL A 290
PRO A 212
GLY A 208
 GOL  A 409 ( 4.8A)
None
None
None
SO4  A 411 ( 4.7A)
 1.37A 5f9zB-4x9fA:
undetectable		 5f9zB-4x9fA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9
(Drosophila
melanogaster) 		4 / 5 PHE A  63
ILE A  24
GLN A  78
ARG A  53
 None
 1.06A 5jm4A-4x9fA:
undetectable		 5jm4A-4x9fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9
(Drosophila
melanogaster) 		4 / 4 PHE A  63
ILE A  24
GLN A  78
ARG A  53
 None
 1.05A 5jm4B-4x9fA:
undetectable		 5jm4B-4x9fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9
(Drosophila
melanogaster) 		4 / 4 VAL A 135
VAL A 131
TYR A 106
GLN A 104
 None
 1.49A 5qgpA-4x9fA:
undetectable		 5qgpA-4x9fA:
16.54