SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x9l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 11 GLY A 125
GLY A 123
ILE A  21
TYR A 130
LEU A 179
 ACP  A 301 (-2.8A)
None
None
None
None
 1.23A 1p91A-4x9lA:
undetectable		 1p91A-4x9lA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 12 ASN A  39
SER A  40
ASP A  42
ASP A  81
THR A 173
 ACP  A 301 (-2.7A)
ACP  A 301 ( 3.7A)
None
ACP  A 301 (-3.9A)
ACP  A 301 (-3.8A)
 0.44A 1s14A-4x9lA:
10.5		 1s14A-4x9lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 12 ASP A  42
ASP A  81
MET A  86
ASP A 144
THR A 173
 None
ACP  A 301 (-3.9A)
ACP  A 301 (-3.4A)
None
ACP  A 301 (-3.8A)
 1.35A 1s14A-4x9lA:
10.5		 1s14A-4x9lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 12 SER A  40
ASP A  42
ASP A  81
ASP A 144
THR A 173
 ACP  A 301 ( 3.7A)
None
ACP  A 301 (-3.9A)
None
ACP  A 301 (-3.8A)
 0.96A 1s14A-4x9lA:
10.5		 1s14A-4x9lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 12 THR A 139
ALA A 129
PHE A 126
ILE A  79
LEU A 187
 PG4  A 302 ( 4.2A)
None
None
None
None
 1.12A 2nyrA-4x9lA:
undetectable		 2nyrA-4x9lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 12 LEU A 209
ILE A 207
ILE A  66
ILE A  68
PHE A  32
 None
 1.09A 2ygoA-4x9lA:
undetectable		 2ygoA-4x9lA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 12 LEU A  36
LEU A  91
ILE A 175
PHE A 126
PHE A  10
 None
 0.94A 2ygqA-4x9lA:
undetectable		 2ygqA-4x9lA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 12 ASN A  39
SER A  40
ASP A  42
ASP A  81
THR A 173
 ACP  A 301 (-2.7A)
ACP  A 301 ( 3.7A)
None
ACP  A 301 (-3.9A)
ACP  A 301 (-3.8A)
 0.42A 3lpsA-4x9lA:
12.4		 3lpsA-4x9lA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 12 SER A  40
ASP A  42
ASP A  81
ASP A 144
THR A 173
 ACP  A 301 ( 3.7A)
None
ACP  A 301 (-3.9A)
None
ACP  A 301 (-3.8A)
 1.15A 3lpsA-4x9lA:
12.4		 3lpsA-4x9lA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 12 SER A  40
ASP A  42
ASP A  81
MET A  86
THR A 173
 ACP  A 301 ( 3.7A)
None
ACP  A 301 (-3.9A)
ACP  A 301 (-3.4A)
ACP  A 301 (-3.8A)
 0.80A 3lpsA-4x9lA:
12.4		 3lpsA-4x9lA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		3 / 3 ASP A 163
GLU A 167
GLY A 166
 None
PG4  A 302 (-2.9A)
None
 0.52A 3w9tA-4x9lA:
undetectable		 3w9tA-4x9lA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 11 ASN A  39
SER A  40
ASP A  42
ASP A  81
THR A 173
 ACP  A 301 (-2.7A)
ACP  A 301 ( 3.7A)
None
ACP  A 301 (-3.9A)
ACP  A 301 (-3.8A)
 0.50A 4urnA-4x9lA:
12.7		 4urnA-4x9lA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 11 SER A  40
ASP A  42
ASP A  81
MET A  86
THR A 173
 ACP  A 301 ( 3.7A)
None
ACP  A 301 (-3.9A)
ACP  A 301 (-3.4A)
ACP  A 301 (-3.8A)
 0.84A 4urnA-4x9lA:
12.7		 4urnA-4x9lA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 11 ASN A  39
SER A  40
ASP A  42
ASP A  81
THR A 173
 ACP  A 301 (-2.7A)
ACP  A 301 ( 3.7A)
None
ACP  A 301 (-3.9A)
ACP  A 301 (-3.8A)
 0.54A 4urnB-4x9lA:
11.9		 4urnB-4x9lA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 11 ASN A  39
SER A  40
ASP A  42
ASP A  81
THR A 173
 ACP  A 301 (-2.7A)
ACP  A 301 ( 3.7A)
None
ACP  A 301 (-3.9A)
ACP  A 301 (-3.8A)
 0.54A 4urnC-4x9lA:
12.3		 4urnC-4x9lA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 11 SER A  40
ASP A  42
ASP A  81
MET A  86
THR A 173
 ACP  A 301 ( 3.7A)
None
ACP  A 301 (-3.9A)
ACP  A 301 (-3.4A)
ACP  A 301 (-3.8A)
 0.83A 4urnC-4x9lA:
12.3		 4urnC-4x9lA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		4 / 4 VAL A 137
VAL A 136
TYR A 178
GLN A 153
 None
 1.37A 5qhbA-4x9lA:
undetectable		 5qhbA-4x9lA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4x9l HEAT SHOCK PROTEIN
(Oryza
sativa) 		5 / 12 THR A 140
THR A 139
VAL A 138
LEU A  36
GLN A  61
 None
PG4  A 302 ( 4.2A)
None
None
None
 1.40A 6ak3A-4x9lA:
undetectable		 6ak3A-4x9lA:
17.00