SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x9q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		6 / 12 SER A 120
GLN A 142
LEU A  81
HIS A  74
ILE A  22
ALA A 160
 None
None
None
MN  A 201 (-3.4A)
None
MN  A 201 ( 4.8A)
 1.15A 2bxcA-4x9qA:
undetectable		 2bxcA-4x9qA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		4 / 6 PHE A 152
TRP A 177
GLY A  85
GLY A  86
 None
 0.97A 2qr2A-4x9qA:
undetectable
2qr2B-4x9qA:
undetectable		 2qr2A-4x9qA:
22.05
2qr2B-4x9qA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		4 / 5 TRP A 177
GLY A  85
GLY A  86
PHE A 152
 None
 1.05A 2qr2A-4x9qA:
undetectable
2qr2B-4x9qA:
undetectable		 2qr2A-4x9qA:
22.05
2qr2B-4x9qA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		4 / 7 VAL A 156
TYR A 165
TYR A 161
ILE A 115
 None
 1.14A 2xz5B-4x9qA:
undetectable
2xz5E-4x9qA:
undetectable		 2xz5B-4x9qA:
18.83
2xz5E-4x9qA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		5 / 11 ILE A  96
THR A  95
ASP A  99
ILE A 185
PRO A  88
 None
 1.26A 3kpcA-4x9qA:
undetectable		 3kpcA-4x9qA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		5 / 12 LEU A 151
GLY A 126
THR A  95
ILE A  96
LEU A 106
 None
 1.19A 4o5fA-4x9qA:
undetectable
4o5fB-4x9qA:
undetectable		 4o5fA-4x9qA:
20.83
4o5fB-4x9qA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		5 / 12 LEU A 106
LEU A 151
GLY A 126
THR A  95
ILE A  96
 None
 1.18A 4o5fA-4x9qA:
undetectable
4o5fB-4x9qA:
undetectable		 4o5fA-4x9qA:
20.83
4o5fB-4x9qA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WMZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		5 / 9 TYR A 161
ILE A 176
TYR A 172
GLY A 123
THR A 138
 None
 1.43A 4wmzA-4x9qA:
0.6		 4wmzA-4x9qA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		5 / 12 LEU A 151
GLY A 126
THR A  95
ILE A  96
LEU A 106
 None
 1.22A 5b8hA-4x9qA:
undetectable
5b8hB-4x9qA:
undetectable		 5b8hA-4x9qA:
17.88
5b8hB-4x9qA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		5 / 12 LEU A 106
LEU A 151
GLY A 126
THR A  95
ILE A  96
 None
 1.23A 5b8hA-4x9qA:
undetectable
5b8hB-4x9qA:
undetectable		 5b8hA-4x9qA:
17.88
5b8hB-4x9qA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		3 / 3 LYS A 108
ASP A 104
ILE A 154
 None
 0.86A 5kc4E-4x9qA:
undetectable		 5kc4E-4x9qA:
22.84