SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		3 / 3 VAL A  12
VAL A  20
TRP A  43
 None
 0.91A 1bdwA-4x9sA:
undetectable
1bdwB-4x9sA:
undetectable		 1bdwA-4x9sA:
7.48
1bdwB-4x9sA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		4 / 8 ASP A 158
ARG A 164
TYR A 165
THR A 191
 None
 1.46A 1ceaA-4x9sA:
undetectable
1ceaB-4x9sA:
undetectable		 1ceaA-4x9sA:
15.58
1ceaB-4x9sA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 12 LEU A 204
LEU A 207
LEU A 210
ALA A 211
LEU A 238
 None
 1.02A 1ya3C-4x9sA:
undetectable		 1ya3C-4x9sA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 10 ALA A  90
ALA A  94
THR A  98
LEU A  82
VAL A  69
 None
 1.35A 2wuzA-4x9sA:
undetectable		 2wuzA-4x9sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 10 ALA A  90
ALA A  94
THR A  98
LEU A  82
VAL A  69
 None
 1.35A 2wuzB-4x9sA:
undetectable		 2wuzB-4x9sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 11 ILE A 127
LEU A  82
LEU A 105
ILE A  86
LEU A  96
 None
 1.28A 3a50C-4x9sA:
undetectable		 3a50C-4x9sA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		4 / 6 GLY A 199
ILE A 201
ILE A 222
ASP A 169
 SO4  A 303 ( 3.7A)
None
None
None
 0.93A 3a7eA-4x9sA:
undetectable		 3a7eA-4x9sA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 12 LEU A 183
ILE A 127
VAL A 195
VAL A 187
LEU A 154
 None
 1.12A 3gwxB-4x9sA:
undetectable		 3gwxB-4x9sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		3 / 3 VAL A  54
VAL A 166
SER A 198
 SO4  A 305 (-4.8A)
None
SO4  A 305 ( 4.3A)
 0.73A 3n8xB-4x9sA:
undetectable		 3n8xB-4x9sA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		6 / 11 LEU A 210
ARG A 102
GLU A   7
LEU A   9
PRO A 194
VAL A 214
 None
 1.50A 3ua5A-4x9sA:
undetectable		 3ua5A-4x9sA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 12 GLY A 174
GLY A 199
ASP A 173
ALA A 226
GLU A  30
 SO4  A 303 (-3.5A)
SO4  A 303 ( 3.7A)
SO4  A 303 (-3.5A)
None
None
 0.84A 4lg1A-4x9sA:
undetectable		 4lg1A-4x9sA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 12 LEU A 204
LEU A 207
LEU A 210
ALA A 211
LEU A 238
 None
 0.91A 4ltwA-4x9sA:
undetectable		 4ltwA-4x9sA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 12 VAL A  20
ALA A  19
VAL A  12
PHE A  60
GLY A  17
 None
 1.08A 4mm4B-4x9sA:
undetectable		 4mm4B-4x9sA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 12 VAL A  54
SER A  83
VAL A 223
ALA A  59
VAL A 166
 SO4  A 305 (-4.8A)
SO4  A 301 ( 4.4A)
SO4  A 303 ( 4.7A)
SO4  A 301 (-3.4A)
None
 1.35A 4nc3A-4x9sA:
undetectable		 4nc3A-4x9sA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 9 ALA A 108
THR A 107
VAL A 103
GLY A  84
ASP A  88
 None
SO4  A 301 (-3.8A)
None
SO4  A 301 ( 3.8A)
None
 1.16A 4qvnK-4x9sA:
undetectable
4qvnL-4x9sA:
undetectable		 4qvnK-4x9sA:
22.83
4qvnL-4x9sA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 9 ALA A 108
THR A 107
VAL A 103
GLY A  84
ASP A  88
 None
SO4  A 301 (-3.8A)
None
SO4  A 301 ( 3.8A)
None
 1.15A 4qvnY-4x9sA:
undetectable
4qvnZ-4x9sA:
undetectable		 4qvnY-4x9sA:
22.83
4qvnZ-4x9sA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 11 ALA A  94
ALA A  93
GLY A  84
GLY A  85
ASP A  88
 None
None
SO4  A 301 ( 3.8A)
SO4  A 301 (-3.5A)
None
 1.10A 4qvwK-4x9sA:
undetectable
4qvwL-4x9sA:
undetectable		 4qvwK-4x9sA:
23.02
4qvwL-4x9sA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 11 THR A 107
ALA A 108
GLY A  61
ASP A  88
SER A  91
 SO4  A 301 (-3.8A)
None
None
None
None
 1.07A 4qvwK-4x9sA:
undetectable
4qvwL-4x9sA:
undetectable		 4qvwK-4x9sA:
23.02
4qvwL-4x9sA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 11 ALA A  94
ALA A  93
GLY A  84
GLY A  85
ASP A  88
 None
None
SO4  A 301 ( 3.8A)
SO4  A 301 (-3.5A)
None
 1.09A 4qvwY-4x9sA:
undetectable
4qvwZ-4x9sA:
undetectable		 4qvwY-4x9sA:
23.02
4qvwZ-4x9sA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 11 THR A 107
ALA A 108
GLY A  61
ASP A  88
SER A  91
 SO4  A 301 (-3.8A)
None
None
None
None
 1.08A 4qvwY-4x9sA:
undetectable
4qvwZ-4x9sA:
undetectable		 4qvwY-4x9sA:
23.02
4qvwZ-4x9sA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 9 ALA A 108
THR A 107
GLY A  84
GLY A  85
ASP A  88
 None
SO4  A 301 (-3.8A)
SO4  A 301 ( 3.8A)
SO4  A 301 (-3.5A)
None
 1.09A 4qwuK-4x9sA:
undetectable
4qwuL-4x9sA:
undetectable		 4qwuK-4x9sA:
22.83
4qwuL-4x9sA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 9 ALA A 108
THR A 107
GLY A  84
GLY A  85
ASP A  88
 None
SO4  A 301 (-3.8A)
SO4  A 301 ( 3.8A)
SO4  A 301 (-3.5A)
None
 1.13A 4qwuY-4x9sA:
undetectable
4qwuZ-4x9sA:
undetectable		 4qwuY-4x9sA:
22.83
4qwuZ-4x9sA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		4 / 5 VAL A  20
ASN A  65
ASP A  55
LEU A  56
 None
 1.23A 5m0iB-4x9sA:
undetectable		 5m0iB-4x9sA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 12 GLY A 174
PRO A 179
GLY A 178
ASP A 173
LEU A  22
 SO4  A 303 (-3.5A)
None
None
SO4  A 303 (-3.5A)
None
 1.12A 5yniA-4x9sA:
undetectable		 5yniA-4x9sA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 12 GLY A 174
PRO A 179
GLY A 178
ASP A 173
LEU A  22
 SO4  A 303 (-3.5A)
None
None
SO4  A 303 (-3.5A)
None
 1.13A 5ynmA-4x9sA:
undetectable		 5ynmA-4x9sA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 9 VAL A  69
ASP A  55
ALA A  19
SER A  32
ASP A  13
 None
None
None
None
SO4  A 305 (-2.8A)
 1.32A 6c2mB-4x9sA:
undetectable		 6c2mB-4x9sA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		5 / 11 VAL A  54
SER A  83
VAL A 223
ALA A  59
VAL A 166
 SO4  A 305 (-4.8A)
SO4  A 301 ( 4.4A)
SO4  A 303 ( 4.7A)
SO4  A 301 (-3.4A)
None
 1.34A 6dryA-4x9sA:
undetectable		 6dryA-4x9sA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4x9s PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sp.
Mg1) 		4 / 6 PHE A  60
LEU A  56
ALA A  59
THR A 168
 None
None
SO4  A 301 (-3.4A)
None
 0.93A 6f88A-4x9sA:
undetectable		 6f88A-4x9sA:
18.02