SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x9t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 12 VAL A 152
LEU A 310
LEU A 314
PRO A 180
GLY A 155
None
1.10A 1jffB-4x9tA:
undetectable
1jffB-4x9tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 12 ASP A 170
THR A  96
SER A 159
ALA A 167
ALA A 164
None
1.30A 1nw5A-4x9tA:
undetectable
1nw5A-4x9tA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 12 VAL A 152
LEU A 310
LEU A 314
PRO A 180
GLY A 155
None
1.10A 2hxfB-4x9tA:
undetectable
2hxfB-4x9tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 12 VAL A 152
LEU A 310
LEU A 314
PRO A 180
GLY A 155
None
1.10A 2hxhB-4x9tA:
undetectable
2hxhB-4x9tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUB_A_2TNA134_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
4 / 4 LEU A 310
ILE A 242
HIS A 162
LYS A 313
None
1.26A 2oubA-4x9tA:
0.0
2oubA-4x9tA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 12 VAL A 152
LEU A 310
LEU A 314
PRO A 180
GLY A 155
None
1.10A 2p4nB-4x9tA:
undetectable
2p4nB-4x9tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 12 VAL A 152
LEU A 310
LEU A 314
PRO A 180
GLY A 155
None
1.10A 2wbeB-4x9tA:
undetectable
2wbeB-4x9tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
4 / 5 TYR A 122
ALA A 219
ALA A 204
TYR A 207
None
None
CL  A 402 (-3.6A)
None
1.23A 3d91A-4x9tA:
undetectable
3d91A-4x9tA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 12 VAL A 152
LEU A 310
LEU A 314
PRO A 180
GLY A 155
None
1.10A 3dcoB-4x9tA:
undetectable
3dcoB-4x9tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 12 VAL A 152
LEU A 310
LEU A 314
PRO A 180
GLY A 155
None
1.09A 3edlB-4x9tA:
undetectable
3edlB-4x9tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
4 / 7 VAL A 252
TYR A  28
THR A  27
GLY A  88
None
0.98A 3gssA-4x9tA:
undetectable
3gssA-4x9tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
4 / 7 VAL A 252
TYR A  28
THR A  27
GLY A  88
None
0.93A 3gssB-4x9tA:
undetectable
3gssB-4x9tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 12 VAL A 152
LEU A 310
LEU A 314
PRO A 180
GLY A 155
None
1.09A 3iz0B-4x9tA:
undetectable
3iz0B-4x9tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
4 / 7 ARG A 119
SER A 222
ARG A 302
ILE A 242
None
0.99A 3ln1C-4x9tA:
undetectable
3ln1C-4x9tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_B_ACTB600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
4 / 5 HIS A 304
ALA A 301
GLU A 112
HIS A 111
None
1.24A 3mbgB-4x9tA:
undetectable
3mbgC-4x9tA:
undetectable
3mbgB-4x9tA:
15.94
3mbgC-4x9tA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
4 / 5 GLU A 112
HIS A 111
HIS A 304
ALA A 301
None
1.24A 3mbgB-4x9tA:
undetectable
3mbgC-4x9tA:
undetectable
3mbgB-4x9tA:
15.94
3mbgC-4x9tA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
3 / 3 ILE A 115
VAL A 261
ARG A 265
None
0.46A 3p73A-4x9tA:
undetectable
3p73A-4x9tA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
4 / 8 PHE A 306
THR A 100
GLY A 245
SER A 243
None
0.90A 3tzfB-4x9tA:
undetectable
3tzfB-4x9tA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 12 GLU A 259
ILE A 260
GLY A 255
VAL A 252
ALA A 251
None
1.18A 4fqsA-4x9tA:
undetectable
4fqsA-4x9tA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 12 GLU A 259
ILE A 260
GLY A 255
VAL A 252
ALA A 251
None
1.21A 4fqsB-4x9tA:
undetectable
4fqsB-4x9tA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 11 ILE A 244
ALA A 164
GLU A 169
GLY A 156
ASN A 157
None
1.26A 4j83A-4x9tA:
undetectable
4j83A-4x9tA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
4 / 7 LEU A  64
SER A  56
ILE A 271
VAL A 272
None
1.10A 4tvtA-4x9tA:
undetectable
4tvtA-4x9tA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
4 / 8 THR A  45
LEU A  48
LEU A 250
LEU A 120
CL  A 403 (-4.0A)
None
None
None
0.78A 4z90F-4x9tA:
undetectable
4z90G-4x9tA:
undetectable
4z90H-4x9tA:
undetectable
4z90I-4x9tA:
undetectable
4z90J-4x9tA:
undetectable
4z90F-4x9tA:
21.33
4z90G-4x9tA:
21.33
4z90H-4x9tA:
21.33
4z90I-4x9tA:
21.33
4z90J-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 10 LEU A  35
LEU A 250
LEU A 120
THR A  45
LEU A  48
None
None
None
CL  A 403 (-4.0A)
None
0.88A 4z91A-4x9tA:
undetectable
4z91B-4x9tA:
undetectable
4z91C-4x9tA:
undetectable
4z91D-4x9tA:
undetectable
4z91E-4x9tA:
undetectable
4z91A-4x9tA:
21.33
4z91B-4x9tA:
21.33
4z91C-4x9tA:
21.33
4z91D-4x9tA:
21.33
4z91E-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 10 LEU A  35
LEU A 250
LEU A 120
THR A  45
LEU A  48
None
None
None
CL  A 403 (-4.0A)
None
0.92A 4z91A-4x9tA:
undetectable
4z91B-4x9tA:
undetectable
4z91C-4x9tA:
undetectable
4z91D-4x9tA:
undetectable
4z91E-4x9tA:
undetectable
4z91A-4x9tA:
21.33
4z91B-4x9tA:
21.33
4z91C-4x9tA:
21.33
4z91D-4x9tA:
21.33
4z91E-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 10 LEU A 120
THR A  45
LEU A  48
LEU A  35
LEU A 250
None
CL  A 403 (-4.0A)
None
None
None
0.89A 4z91A-4x9tA:
undetectable
4z91B-4x9tA:
undetectable
4z91C-4x9tA:
undetectable
4z91D-4x9tA:
undetectable
4z91E-4x9tA:
undetectable
4z91A-4x9tA:
21.33
4z91B-4x9tA:
21.33
4z91C-4x9tA:
21.33
4z91D-4x9tA:
21.33
4z91E-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 10 LEU A 250
LEU A 120
THR A  45
LEU A  48
LEU A  35
None
None
CL  A 403 (-4.0A)
None
None
0.95A 4z91A-4x9tA:
undetectable
4z91B-4x9tA:
undetectable
4z91C-4x9tA:
undetectable
4z91D-4x9tA:
undetectable
4z91E-4x9tA:
undetectable
4z91A-4x9tA:
21.33
4z91B-4x9tA:
21.33
4z91C-4x9tA:
21.33
4z91D-4x9tA:
21.33
4z91E-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 10 THR A  45
LEU A  48
LEU A  35
LEU A 250
LEU A 120
CL  A 403 (-4.0A)
None
None
None
None
0.96A 4z91A-4x9tA:
undetectable
4z91B-4x9tA:
undetectable
4z91C-4x9tA:
undetectable
4z91D-4x9tA:
undetectable
4z91E-4x9tA:
undetectable
4z91A-4x9tA:
21.33
4z91B-4x9tA:
21.33
4z91C-4x9tA:
21.33
4z91D-4x9tA:
21.33
4z91E-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
6 / 9 ALA A  53
LEU A  35
LEU A 250
LEU A 120
LEU A  48
ALA A  51
None
1.03A 4z91F-4x9tA:
undetectable
4z91G-4x9tA:
undetectable
4z91H-4x9tA:
undetectable
4z91I-4x9tA:
undetectable
4z91J-4x9tA:
undetectable
4z91F-4x9tA:
21.33
4z91G-4x9tA:
21.33
4z91H-4x9tA:
21.33
4z91I-4x9tA:
21.33
4z91J-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
6 / 9 LEU A  48
ALA A  51
ALA A  53
LEU A  35
LEU A 250
LEU A 120
None
1.06A 4z91F-4x9tA:
undetectable
4z91G-4x9tA:
undetectable
4z91H-4x9tA:
undetectable
4z91I-4x9tA:
undetectable
4z91J-4x9tA:
undetectable
4z91F-4x9tA:
21.33
4z91G-4x9tA:
21.33
4z91H-4x9tA:
21.33
4z91I-4x9tA:
21.33
4z91J-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
6 / 9 LEU A 120
LEU A  48
ALA A  51
ALA A  53
LEU A  35
LEU A 250
None
1.11A 4z91F-4x9tA:
undetectable
4z91G-4x9tA:
undetectable
4z91H-4x9tA:
undetectable
4z91I-4x9tA:
undetectable
4z91J-4x9tA:
undetectable
4z91F-4x9tA:
21.33
4z91G-4x9tA:
21.33
4z91H-4x9tA:
21.33
4z91I-4x9tA:
21.33
4z91J-4x9tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
4 / 6 PHE A 176
VAL A 152
MET A 221
ILE A 127
None
1.19A 5iwuA-4x9tA:
undetectable
5iwuA-4x9tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
5 / 10 VAL A 174
ILE A 127
VAL A 138
PHE A 141
ALA A 144
None
1.09A 5nukA-4x9tA:
undetectable
5nukA-4x9tA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas
sp.
JS666)
4 / 7 HIS A 111
THR A 110
ARG A 302
ASP A 303
None
1.33A 6mn4E-4x9tA:
undetectable
6mn4E-4x9tA:
23.36