SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		4 / 7 ASN A 246
TYR A 254
ASN A 253
VAL A 229
 None
 1.18A 1wu8A-4x9xA:
2.9
1wu8C-4x9xA:
2.9		 1wu8A-4x9xA:
21.20
1wu8C-4x9xA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		4 / 6 ILE A 263
THR A 260
VAL A 158
SER A 119
 OLA  A 301 ( 3.7A)
None
None
OLA  A 301 ( 3.3A)
 1.12A 4iaqA-4x9xA:
undetectable		 4iaqA-4x9xA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		3 / 3 ILE A 118
ASP A   9
ARG A 170
 OLA  A 301 (-3.7A)
None
OLA  A 301 (-3.3A)
 0.79A 4pstA-4x9xA:
undetectable		 4pstA-4x9xA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		5 / 12 GLY A 121
GLY A 123
ILE A 118
LEU A 277
VAL A 275
 None
None
OLA  A 301 (-3.7A)
None
None
 1.05A 4qdjA-4x9xA:
undetectable		 4qdjA-4x9xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		5 / 12 SER A  71
THR A  95
THR A  98
ALA A  99
ALA A 102
 None
 0.93A 4u15A-4x9xA:
undetectable		 4u15A-4x9xA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		5 / 12 SER A 264
ASP A  40
PHE A  49
ALA A 232
ASP A  13
 EDO  A 302 (-2.7A)
None
EDO  A 302 ( 4.8A)
EDO  A 302 (-2.7A)
OLA  A 301 ( 4.7A)
 1.20A 4ubeA-4x9xA:
undetectable		 4ubeA-4x9xA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		5 / 11 GLY A 268
ILE A 171
LEU A 195
LEU A  92
ILE A 263
 None
None
OLA  A 301 ( 3.9A)
OLA  A 301 (-3.6A)
OLA  A 301 ( 3.7A)
 1.17A 4xumB-4x9xA:
undetectable		 4xumB-4x9xA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		3 / 3 THR A 267
HIS A  87
LEU A  29
 OLA  A 301 ( 3.4A)
None
OLA  A 301 (-4.4A)
 0.67A 5axdA-4x9xA:
2.5		 5axdA-4x9xA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		4 / 6 ALA A 265
SER A 264
GLN A  41
SER A  10
 None
EDO  A 302 (-2.7A)
None
None
 0.87A 5c6pA-4x9xA:
undetectable		 5c6pA-4x9xA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		4 / 5 HIS A 266
VAL A 157
GLY A 160
ALA A 271
 OLA  A 301 (-2.7A)
OLA  A 301 ( 3.6A)
None
OLA  A 301 (-3.0A)
 0.90A 5hwaA-4x9xA:
undetectable		 5hwaA-4x9xA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		4 / 7 HIS A  87
HIS A  25
ILE A  27
VAL A  26
 None
 1.29A 5kkzM-4x9xA:
undetectable
5kkzO-4x9xA:
undetectable		 5kkzM-4x9xA:
21.31
5kkzO-4x9xA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		4 / 8 GLN A 127
ILE A 118
ALA A 230
VAL A 229
 None
OLA  A 301 (-3.7A)
OLA  A 301 ( 3.1A)
None
 0.98A 6hu9a-4x9xA:
undetectable
6hu9e-4x9xA:
undetectable		 6hu9a-4x9xA:
18.61
6hu9e-4x9xA:
17.73