SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xa2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 6 VAL A   8
VAL A  50
ILE A  60
ASN A 267
 None
 0.95A 1e06A-4xa2A:
undetectable		 1e06A-4xa2A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 10 LEU A1067
LYS A1050
LEU A1059
GLU A1053
ALA A1047
 None
 1.26A 1ie4A-4xa2A:
undetectable
1ie4C-4xa2A:
undetectable		 1ie4A-4xa2A:
15.32
1ie4C-4xa2A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		3 / 3 GLU A 111
TRP A 230
LYS A 273
 MLR  A1201 (-3.1A)
MLR  A1201 (-4.4A)
None
 1.19A 1qu2A-4xa2A:
undetectable		 1qu2A-4xa2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 11 ALA A  52
LYS A1094
ALA A1073
SER A1031
THR A1035
 None
 1.22A 1tz8A-4xa2A:
undetectable
1tz8B-4xa2A:
undetectable		 1tz8A-4xa2A:
13.99
1tz8B-4xa2A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 11 THR A  93
GLN A 325
ALA A 324
ALA A 303
ALA A 301
 None
 1.13A 2f16H-4xa2A:
undetectable
2f16I-4xa2A:
undetectable		 2f16H-4xa2A:
22.13
2f16I-4xa2A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 11 THR A  93
GLN A 325
ALA A 324
ALA A 303
ALA A 301
 None
 1.12A 2f16V-4xa2A:
undetectable
2f16W-4xa2A:
undetectable		 2f16V-4xa2A:
22.13
2f16W-4xa2A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		3 / 3 SER A  73
THR A1096
GLN A1025
 None
 0.75A 2fk8A-4xa2A:
undetectable		 2fk8A-4xa2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 7 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
 1.08A 2q6oA-4xa2A:
2.1		 2q6oA-4xa2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.09A 2ve3A-4xa2A:
undetectable		 2ve3A-4xa2A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 6 PHE A 258
ALA A 162
LEU A 247
PRO A 159
 None
 0.95A 3bgdA-4xa2A:
undetectable		 3bgdA-4xa2A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 7 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.66A 3bjwC-4xa2A:
undetectable		 3bjwC-4xa2A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 8 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.83A 3bjwA-4xa2A:
undetectable		 3bjwA-4xa2A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 6 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.34A 3gv1A-4xa2A:
undetectable
3gv1C-4xa2A:
undetectable		 3gv1A-4xa2A:
15.66
3gv1C-4xa2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 6 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.32A 3gv1A-4xa2A:
undetectable
3gv1B-4xa2A:
undetectable		 3gv1A-4xa2A:
15.66
3gv1B-4xa2A:
15.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		11 / 12 ASP A  14
LYS A  15
GLU A  44
GLU A  45
ALA A  63
ASP A  65
ARG A  66
GLU A 111
PRO A 154
TRP A 230
TYR A 341
 MLR  A1201 (-3.2A)
MLR  A1201 (-2.9A)
MLR  A1201 (-3.5A)
MLR  A1201 (-3.8A)
MLR  A1201 (-3.3A)
MLR  A1201 (-2.9A)
MLR  A1201 (-4.0A)
MLR  A1201 (-3.1A)
MLR  A1201 (-3.5A)
MLR  A1201 (-4.4A)
MLR  A1201 (-4.1A)
 0.34A 3jyrA-4xa2A:
62.4		 3jyrA-4xa2A:
73.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		6 / 7 ASN A  12
TRP A  62
GLU A 153
TYR A 155
MET A 330
TRP A 340
 MLR  A1201 ( 4.7A)
MLR  A1201 (-4.4A)
MLR  A1201 (-3.2A)
MLR  A1201 (-3.8A)
MLR  A1201 ( 4.4A)
MLR  A1201 (-4.1A)
 0.21A 3jyrA-4xa2A:
62.4		 3jyrA-4xa2A:
73.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		3 / 3 ALA A1120
ARG A1122
LYS A1124
 None
 0.97A 3kp3B-4xa2A:
undetectable		 3kp3B-4xa2A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 11 THR A  93
GLN A 325
ALA A 324
ALA A 303
ALA A 301
 None
 1.16A 3mg0V-4xa2A:
undetectable
3mg0W-4xa2A:
undetectable		 3mg0V-4xa2A:
22.13
3mg0W-4xa2A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 EDO  A1202 ( 4.5A)
None
None
None
None
 1.00A 3n8yB-4xa2A:
0.0		 3n8yB-4xa2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 7 LYS A1094
ALA A1073
SER A1031
THR A1035
 None
 0.99A 3ozkB-4xa2A:
undetectable		 3ozkB-4xa2A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 8 ASN A 185
ASP A 180
GLU A 328
TRP A 158
 None
 1.10A 3sg9B-4xa2A:
undetectable		 3sg9B-4xa2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 9 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.19A 3sj4X-4xa2A:
undetectable		 3sj4X-4xa2A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MLR  A1201 (-3.1A)
None
 0.84A 3tbgB-4xa2A:
undetectable		 3tbgB-4xa2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MLR  A1201 (-3.1A)
None
 0.82A 3tbgD-4xa2A:
undetectable		 3tbgD-4xa2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.37A 3vwqA-4xa2A:
undetectable		 3vwqA-4xa2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 6 GLU A 308
ASP A 314
ASP A 287
ASN A 294
 None
 1.31A 3vywA-4xa2A:
undetectable		 3vywA-4xa2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 5 GLU A 308
ASP A 314
ASP A 287
ASN A 294
 None
 1.29A 3vywD-4xa2A:
undetectable		 3vywD-4xa2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 7 LYS A1094
ALA A1073
SER A1031
THR A1035
 None
 1.10A 4iklA-4xa2A:
undetectable
4iklB-4xa2A:
undetectable		 4iklA-4xa2A:
13.99
4iklB-4xa2A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.17A 4or0B-4xa2A:
undetectable		 4or0B-4xa2A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 4 VAL A1033
ALA A1029
ASN A1026
GLN A1098
 None
 0.97A 4zgfA-4xa2A:
undetectable		 4zgfA-4xa2A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 4 VAL A 110
ALA A 112
ILE A 317
THR A 320
 None
 1.19A 5e4dB-4xa2A:
undetectable		 5e4dB-4xa2A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 8 GLY A 166
LYS A 189
ALA A 190
ASP A 184
 None
 0.99A 5mvsB-4xa2A:
undetectable		 5mvsB-4xa2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
 1.46A 5w4zA-4xa2A:
undetectable		 5w4zA-4xa2A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
 1.49A 5w4zB-4xa2A:
undetectable		 5w4zB-4xa2A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		3 / 3 TYR A 155
ASN A 227
LEU A 113
 MLR  A1201 (-3.8A)
None
None
 0.82A 6b58A-4xa2A:
undetectable		 6b58A-4xa2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.47A 6bm5A-4xa2A:
undetectable		 6bm5A-4xa2A:
22.29