SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xa8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
 None
 0.92A 1fm6A-4xa8A:
undetectable		 1fm6A-4xa8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		4 / 8 PRO A 289
SER A  13
PHE A  11
ASP A  20
 None
 1.23A 1p7lC-4xa8A:
undetectable		 1p7lC-4xa8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 VAL A  51
PHE A  67
VAL A  44
VAL A  73
ALA A  54
 None
 1.10A 1q23H-4xa8A:
undetectable
1q23I-4xa8A:
undetectable		 1q23H-4xa8A:
21.04
1q23I-4xa8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
 None
 0.91A 1xlsA-4xa8A:
undetectable		 1xlsA-4xa8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
 None
 0.92A 1xlsB-4xa8A:
undetectable		 1xlsB-4xa8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
 None
 0.91A 1xlsC-4xa8A:
undetectable		 1xlsC-4xa8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
 None
 0.91A 1xlsD-4xa8A:
undetectable		 1xlsD-4xa8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
 None
 0.97A 2aclG-4xa8A:
undetectable		 2aclG-4xa8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA602_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		4 / 5 HIS A 282
ILE A 286
PRO A 281
ASP A 258
 None
 1.04A 2f7fA-4xa8A:
0.7		 2f7fA-4xa8A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		4 / 8 PRO A 289
SER A  13
PHE A  11
ASP A  20
 None
 1.19A 2p02A-4xa8A:
undetectable		 2p02A-4xa8A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 10 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
 None
 0.95A 3falC-4xa8A:
undetectable		 3falC-4xa8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 11 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
 None
 0.97A 3fc6A-4xa8A:
undetectable		 3fc6A-4xa8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		3 / 3 ARG A 119
GLU A 254
ASP A 275
 None
 0.93A 3g2oA-4xa8A:
7.3		 3g2oA-4xa8A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		4 / 6 ALA A 158
GLY A 147
LEU A 162
VAL A 169
 None
 0.98A 4dubA-4xa8A:
undetectable		 4dubA-4xa8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		3 / 3 LYS A  71
TYR A  53
ARG A  52
 None
 1.42A 4gc9A-4xa8A:
4.7		 4gc9A-4xa8A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 ALA A 233
VAL A 203
PHE A 260
GLY A 235
THR A 280
 None
 1.17A 4mm4B-4xa8A:
undetectable		 4mm4B-4xa8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		4 / 8 PRO A 289
SER A  13
PHE A  11
ASP A  20
 None
 1.24A 4ndnA-4xa8A:
undetectable		 4ndnA-4xa8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		4 / 6 VAL A  15
ASP A  16
SER A 285
ALA A 292
 None
 1.20A 4nedA-4xa8A:
undetectable		 4nedA-4xa8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		4 / 4 THR A 175
GLY A 152
ASP A 153
SER A 173
 None
 1.24A 4rfqA-4xa8A:
5.1		 4rfqA-4xa8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 GLY A  42
ALA A  37
PHE A  64
ALA A  54
VAL A  73
 None
 1.35A 4ryaA-4xa8A:
undetectable		 4ryaA-4xa8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 ALA A 158
GLY A 150
GLY A 155
ALA A 233
LEU A 149
 None
 0.75A 5c0oG-4xa8A:
7.3		 5c0oG-4xa8A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
 None
 0.91A 5uanA-4xa8A:
undetectable		 5uanA-4xa8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
 None
 0.92A 5z12B-4xa8A:
undetectable		 5z12B-4xa8A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING
(Xanthobacter
autotrophicus) 		5 / 12 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
 None
 0.92A 5z12C-4xa8A:
undetectable		 5z12C-4xa8A:
13.50