SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xa9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		5 / 11 LEU A  49
VAL A  97
ILE A 102
GLY A  82
ILE A  73
 None
 0.96A 1c6yA-4xa9A:
undetectable		 1c6yA-4xa9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		5 / 10 LEU A  49
VAL A  97
ILE A 102
GLY A  82
ILE A  73
 None
 0.92A 1hsgA-4xa9A:
undetectable		 1hsgA-4xa9A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		4 / 5 ILE A 235
SER A 201
LEU A 229
ASN A 232
 None
 1.02A 1y0xX-4xa9A:
undetectable		 1y0xX-4xa9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		4 / 4 LEU A 157
SER A 137
LEU A 187
LEU A 166
 None
 1.13A 1yajA-4xa9A:
undetectable		 1yajA-4xa9A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		4 / 5 LEU A 157
SER A 137
LEU A 187
LEU A 166
 None
 1.15A 1yajD-4xa9A:
undetectable		 1yajD-4xa9A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		5 / 12 LEU A  21
ILE A  73
ILE A  78
GLY A  58
LEU A  47
 None
 0.85A 2o4nA-4xa9A:
undetectable		 2o4nA-4xa9A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		5 / 9 LEU A  49
VAL A  97
ILE A 102
GLY A  82
ILE A  73
 None
 0.91A 3ekqB-4xa9A:
undetectable		 3ekqB-4xa9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		5 / 12 LEU A  19
CYH A  35
THR A  66
VAL A  68
PHE A  62
 None
 1.46A 3gn8B-4xa9A:
undetectable		 3gn8B-4xa9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		3 / 3 GLN A  39
THR A  66
LEU A   3
 None
 0.67A 3ondA-4xa9A:
undetectable		 3ondA-4xa9A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		3 / 3 GLN A  39
THR A  66
LEU A   3
 None
 0.68A 3ondB-4xa9A:
undetectable		 3ondB-4xa9A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		5 / 12 LEU A 122
ALA A 111
ILE A 167
LEU A 149
GLY A 193
 None
 1.27A 4l9qA-4xa9A:
undetectable		 4l9qA-4xa9A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		5 / 12 LEU A  16
GLN A  18
GLY A  11
SER A  74
ASN A  72
 None
 1.30A 5d0yA-4xa9A:
undetectable		 5d0yA-4xa9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		5 / 9 LEU A  49
VAL A  97
ILE A 102
GLY A  82
ILE A  73
 None
 0.96A 5kqxB-4xa9A:
undetectable		 5kqxB-4xa9A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		4 / 8 ASN A 243
ILE A 228
LEU A 229
LEU A 240
 None
 0.97A 5u4sB-4xa9A:
undetectable		 5u4sB-4xa9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		5 / 12 ILE A 163
LEU A 166
GLY A 130
ALA A 131
LEU A 149
 None
 1.19A 5zwrA-4xa9A:
undetectable		 5zwrA-4xa9A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		5 / 11 GLY A 177
SER A 201
LEU A 192
ALA A 182
PHE A 205
 None
 1.28A 6qgbA-4xa9A:
undetectable		 6qgbA-4xa9A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4xa9 GALA PROTEIN TYPE 1,
3 OR 4
(Legionella
pneumophila) 		5 / 11 GLY A 177
SER A 201
LEU A 192
ALA A 182
PHE A 205
 None
 1.28A 6qgbE-4xa9A:
undetectable		 6qgbE-4xa9A:
17.99