SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xaa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		4 / 5 ASP A 127
HIS A 125
HIS A 190
HIS A 196
 NI  A 301 (-2.5A)
NI  A 301 (-3.4A)
None
NI  A 301 (-3.4A)
 1.25A 1ei6A-4xaaA:
undetectable		 1ei6A-4xaaA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		5 / 12 HIS A 125
ASP A 127
LEU A 153
HIS A 196
VAL A 211
 NI  A 301 (-3.4A)
NI  A 301 (-2.5A)
None
NI  A 301 (-3.4A)
None
 0.55A 1uobA-4xaaA:
10.7		 1uobA-4xaaA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		3 / 3 ASN A 150
ASP A 144
ARG A  66
 None
 0.79A 3k13A-4xaaA:
undetectable		 3k13A-4xaaA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		3 / 3 ARG A  14
PRO A 179
PHE A  20
 None
 0.96A 3thrC-4xaaA:
undetectable		 3thrC-4xaaA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		4 / 7 TYR A 214
TYR A 109
PRO A 106
HIS A  88
 None
 1.17A 4g5jA-4xaaA:
undetectable		 4g5jA-4xaaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		4 / 7 HIS A 196
ASP A 127
HIS A 190
VAL A 112
 NI  A 301 (-3.4A)
NI  A 301 (-2.5A)
None
None
 1.10A 4hvrA-4xaaA:
5.4		 4hvrA-4xaaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		5 / 12 LEU A  42
ARG A  45
ILE A 210
LEU A 111
LEU A  86
 None
 1.15A 4j24D-4xaaA:
undetectable		 4j24D-4xaaA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		5 / 12 LEU A 194
ASP A 127
VAL A 192
LEU A  95
VAL A 211
 None
NI  A 301 (-2.5A)
None
None
None
 1.36A 4nc3A-4xaaA:
undetectable		 4nc3A-4xaaA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		4 / 6 ALA A 155
VAL A 178
VAL A 188
HIS A 196
 None
None
None
NI  A 301 (-3.4A)
 1.04A 5eckA-4xaaA:
undetectable		 5eckA-4xaaA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		4 / 6 ALA A 155
VAL A 178
VAL A 188
HIS A 196
 None
None
None
NI  A 301 (-3.4A)
 1.06A 5eckD-4xaaA:
undetectable		 5eckD-4xaaA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		5 / 9 LEU A  86
ILE A  32
ILE A 212
GLU A  76
GLU A  90
 None
 1.26A 5igzA-4xaaA:
undetectable		 5igzA-4xaaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		3 / 3 THR A 209
SER A 140
ASP A 127
 None
None
NI  A 301 (-2.5A)
 0.82A 5kvaA-4xaaA:
undetectable		 5kvaA-4xaaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		4 / 6 GLU A  83
ARG A  41
GLU A  40
ALA A  39
 None
 1.16A 6an0A-4xaaA:
undetectable		 6an0A-4xaaA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		5 / 12 VAL A 131
GLY A 158
PHE A  15
GLU A 213
VAL A 100
 None
 1.13A 6bqgA-4xaaA:
undetectable		 6bqgA-4xaaA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4xaa PUTATIVE OXYGENASE
(Streptomyces
viridochromogene
s) 		4 / 5 ARG A 208
ALA A  39
GLN A 184
ILE A  32
 None
 1.42A 6g9bA-4xaaA:
undetectable
6g9bB-4xaaA:
undetectable		 6g9bA-4xaaA:
16.29
6g9bB-4xaaA:
16.82