SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4xac EVDO2
(Micromonospora
carbonacea) 		5 / 12 LEU A 109
ILE A  97
ALA A  98
VAL A 208
ARG A 142
 None
 0.95A 1cbsA-4xacA:
undetectable		 1cbsA-4xacA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4xac EVDO2
(Micromonospora
carbonacea) 		4 / 5 ASP A 131
HIS A 129
HIS A 209
HIS A 215
 NI  A 301 (-2.5A)
NI  A 301 (-3.3A)
AKG  A 303 (-4.4A)
NI  A 301 ( 3.3A)
 1.09A 1ei6A-4xacA:
undetectable		 1ei6A-4xacA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4xac EVDO2
(Micromonospora
carbonacea) 		5 / 12 TYR A 229
TYR A  81
HIS A  90
TYR A 112
PHE A 233
 None
 1.34A 1fmlA-4xacA:
undetectable		 1fmlA-4xacA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 4xac EVDO2
(Micromonospora
carbonacea) 		5 / 11 GLU A  79
GLY A 113
ARG A  93
GLU A  34
PRO A  89
 None
 1.28A 1mjqA-4xacA:
undetectable
1mjqB-4xacA:
undetectable		 1mjqA-4xacA:
18.07
1mjqB-4xacA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4xac EVDO2
(Micromonospora
carbonacea) 		5 / 12 HIS A 129
ASP A 131
LEU A 160
HIS A 215
VAL A 230
 NI  A 301 (-3.3A)
NI  A 301 (-2.5A)
None
NI  A 301 ( 3.3A)
AKG  A 303 ( 4.8A)
 0.89A 1uobA-4xacA:
9.7		 1uobA-4xacA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 4xac EVDO2
(Micromonospora
carbonacea) 		4 / 7 TYR A 162
HIS A 129
HIS A 209
TRP A 128
 None
NI  A 301 (-3.3A)
AKG  A 303 (-4.4A)
None
 1.24A 1yvmA-4xacA:
undetectable		 1yvmA-4xacA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 4xac EVDO2
(Micromonospora
carbonacea) 		5 / 12 ILE A  75
LEU A 150
LEU A  38
GLU A  79
LEU A  85
 None
 1.04A 2bxfA-4xacA:
undetectable		 2bxfA-4xacA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 4xac EVDO2
(Micromonospora
carbonacea) 		5 / 12 LEU A 109
ILE A  97
ALA A  98
VAL A 208
ARG A 142
 None
 0.99A 2fr3A-4xacA:
undetectable		 2fr3A-4xacA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4xac EVDO2
(Micromonospora
carbonacea) 		4 / 5 PRO A  70
PRO A  73
ILE A  60
GLY A  62
 None
 1.12A 2jkjD-4xacA:
undetectable		 2jkjD-4xacA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4xac EVDO2
(Micromonospora
carbonacea) 		4 / 5 PRO A  70
PRO A  73
ILE A  60
GLY A  62
 None
 1.12A 2jkjF-4xacA:
1.2		 2jkjF-4xacA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4xac EVDO2
(Micromonospora
carbonacea) 		3 / 3 TRP A 147
GLN A  74
TRP A 128
 AKG  A 303 (-4.0A)
None
None
 1.16A 2vqyA-4xacA:
undetectable		 2vqyA-4xacA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4xac EVDO2
(Micromonospora
carbonacea) 		5 / 12 PRO A 164
GLY A 165
GLY A 166
ASP A  14
VAL A 207
 None
 1.08A 4b17A-4xacA:
undetectable		 4b17A-4xacA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4xac EVDO2
(Micromonospora
carbonacea) 		4 / 7 VAL A 208
ILE A  97
ARG A  93
ILE A  10
 None
 0.83A 4lv9B-4xacA:
undetectable		 4lv9B-4xacA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4xac EVDO2
(Micromonospora
carbonacea) 		3 / 3 GLY A 169
PRO A 170
GLN A 130
 None
 0.50A 4qwpB-4xacA:
undetectable		 4qwpB-4xacA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xac EVDO2
(Micromonospora
carbonacea) 		5 / 12 TYR A 112
GLY A 113
LEU A 102
PHE A  18
GLY A  22
 None
 1.14A 4ze1A-4xacA:
undetectable		 4ze1A-4xacA:
18.00