SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 10 VAL A 230
TYR A 220
GLY A 233
HIS A 264
ARG A 294
 None
 1.31A 1equA-4xaeA:
undetectable		 1equA-4xaeA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		6 / 12 HIS A 235
ASP A 237
LEU A 252
HIS A 293
SER A 305
PHE A 309
 NA  A 400 (-3.7A)
NA  A 400 (-2.3A)
None
NA  A 400 (-3.7A)
None
None
 0.67A 1uobA-4xaeA:
21.4		 1uobA-4xaeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 SER A 153
LEU A 252
HIS A 293
SER A 305
PHE A 309
 None
None
NA  A 400 (-3.7A)
None
None
 1.39A 1uobA-4xaeA:
21.4		 1uobA-4xaeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 11 HIS A 235
ASP A 237
HIS A 293
VAL A 295
SER A 305
 NA  A 400 (-3.7A)
NA  A 400 (-2.3A)
NA  A 400 (-3.7A)
None
None
 0.85A 1uofA-4xaeA:
20.2		 1uofA-4xaeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 11 HIS A 235
ASP A 237
THR A 242
HIS A 293
VAL A 295
 NA  A 400 (-3.7A)
NA  A 400 (-2.3A)
None
NA  A 400 (-3.7A)
None
 0.54A 1uofA-4xaeA:
20.2		 1uofA-4xaeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 GLU A 323
LEU A 321
ILE A 332
GLY A 286
LEU A 287
 None
 1.17A 2j7xA-4xaeA:
undetectable		 2j7xA-4xaeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		4 / 6 MET A 280
PRO A 312
ILE A 282
LEU A 321
 None
 1.21A 2wekB-4xaeA:
undetectable		 2wekB-4xaeA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 10 THR A  33
ILE A  35
GLY A  34
GLY A  29
PRO A  39
 None
 0.97A 2y7wB-4xaeA:
undetectable		 2y7wB-4xaeA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 GLU A 323
LEU A 321
ILE A 332
GLY A 286
LEU A 287
 None
 1.17A 2yjaB-4xaeA:
undetectable		 2yjaB-4xaeA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		4 / 7 PRO A  63
LEU A 188
GLY A  87
ALA A  82
 None
 0.81A 3tehB-4xaeA:
undetectable		 3tehB-4xaeA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		3 / 3 PHE A 156
LYS A 182
SER A 181
 None
 0.83A 3tyeB-4xaeA:
undetectable		 3tyeB-4xaeA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 ILE A 213
ILE A 274
ILE A 308
ILE A 276
LEU A 192
 None
 1.00A 3uj6A-4xaeA:
undetectable		 3uj6A-4xaeA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		4 / 6 GLY A 299
PRO A 224
GLY A  34
GLU A  32
 None
 0.80A 4dxuA-4xaeA:
undetectable		 4dxuA-4xaeA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 8 ASN A 275
ASP A 237
PHE A  88
VAL A 254
HIS A 235
 None
NA  A 400 (-2.3A)
None
None
NA  A 400 (-3.7A)
 1.45A 4f5zA-4xaeA:
undetectable		 4f5zA-4xaeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 201
LEU A 189
LEU A 192
MET A 283
ALA A 279
 None
 1.01A 4fn9A-4xaeA:
undetectable		 4fn9A-4xaeA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 GLU A 323
LEU A 321
ILE A 332
GLY A 286
LEU A 287
 None
 1.19A 4j26A-4xaeA:
undetectable		 4j26A-4xaeA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		4 / 7 HIS A 235
ASP A 237
SER A 153
PHE A 309
 NA  A 400 (-3.7A)
NA  A 400 (-2.3A)
None
None
 1.33A 4ndnC-4xaeA:
undetectable		 4ndnC-4xaeA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		3 / 3 ASP A 278
LYS A 289
LEU A 257
 None
 0.98A 4ptjA-4xaeA:
undetectable		 4ptjA-4xaeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 11 GLU A 323
LEU A 321
ILE A 332
GLY A 286
LEU A 287
 None
 1.15A 4pxmB-4xaeA:
undetectable		 4pxmB-4xaeA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		3 / 3 THR A 123
ASN A 126
SER A 127
 None
 0.76A 4tvtA-4xaeA:
undetectable		 4tvtA-4xaeA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 152
ASP A 237
SER A 239
ASN A 218
VAL A 306
 None
NA  A 400 (-2.3A)
None
None
None
 1.25A 5d0yB-4xaeA:
undetectable		 5d0yB-4xaeA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		5 / 11 GLU A 323
LEU A 321
ILE A 332
GLY A 286
LEU A 287
 None
 1.15A 5dxbB-4xaeA:
undetectable		 5dxbB-4xaeA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4xae FERULOYL COA
ORTHO-HYDROXYLASE 1
(Arabidopsis
thaliana) 		4 / 7 GLN A  44
GLY A 231
ASP A 150
TYR A 151
 None
 1.03A 5vlmC-4xaeA:
undetectable		 5vlmC-4xaeA:
17.87