SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xat'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4xat NOELIN
(Homo
sapiens) 		4 / 8 ALA A 366
THR A 389
ILE A 320
SER A 380
 None
 0.73A 1c9sU-4xatA:
undetectable
1c9sV-4xatA:
undetectable		 1c9sU-4xatA:
15.15
1c9sV-4xatA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 4xat NOELIN
(Homo
sapiens) 		4 / 5 ASP A 356
ASP A 453
TYR A 454
GLU A 404
 CA  A 501 ( 2.7A)
NA  A 504 ( 2.8A)
None
CA  A 501 (-2.9A)
 1.39A 3l2uA-4xatA:
undetectable		 3l2uA-4xatA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 4xat NOELIN
(Homo
sapiens) 		4 / 5 ASP A 356
ASP A 453
TYR A 454
GLU A 404
 CA  A 501 ( 2.7A)
NA  A 504 ( 2.8A)
None
CA  A 501 (-2.9A)
 1.36A 3l2wA-4xatA:
undetectable		 3l2wA-4xatA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4xat NOELIN
(Homo
sapiens) 		5 / 12 VAL A 262
ARG A 275
ILE A 470
ALA A 460
TYR A 472
 None
None
None
GOL  A 503 ( 3.7A)
None
 1.10A 3ohtA-4xatA:
undetectable
3ohtB-4xatA:
undetectable		 3ohtA-4xatA:
20.98
3ohtB-4xatA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4xat NOELIN
(Homo
sapiens) 		4 / 5 SER A 353
ASP A 453
ASP A 360
ILE A 407
 None
NA  A 504 ( 2.8A)
None
None
 1.25A 3uj7B-4xatA:
undetectable		 3uj7B-4xatA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4xat NOELIN
(Homo
sapiens) 		4 / 8 SER A 242
GLY A 243
ILE A 449
GLY A 247
 None
 0.73A 5alcL-4xatA:
undetectable		 5alcL-4xatA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4xat NOELIN
(Homo
sapiens) 		5 / 12 GLY A 403
ASN A 416
GLY A 350
GLY A 420
SER A 419
 None
 1.25A 5hikA-4xatA:
undetectable		 5hikA-4xatA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 4xat NOELIN
(Homo
sapiens) 		5 / 9 PRO A 253
MET A 250
VAL A 359
LEU A 364
ASP A 356
 None
None
None
None
CA  A 501 ( 2.7A)
 1.27A 5tixA-4xatA:
undetectable		 5tixA-4xatA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 4xat NOELIN
(Homo
sapiens) 		5 / 10 PRO A 253
MET A 250
VAL A 359
LEU A 364
ASP A 356
 None
None
None
None
CA  A 501 ( 2.7A)
 1.29A 5tixB-4xatA:
undetectable		 5tixB-4xatA:
20.54