SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4xav GLIOMEDIN
(Mus
musculus) 		4 / 5 SER A 377
PHE A 391
GLU A 392
GLY A 394
 None
 1.31A 1icvC-4xavA:
undetectable
1icvD-4xavA:
undetectable		 1icvC-4xavA:
19.72
1icvD-4xavA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4xav GLIOMEDIN
(Mus
musculus) 		4 / 7 ILE A 478
PHE A 473
PHE A 505
ILE A 301
 None
 0.84A 2y7wC-4xavA:
undetectable		 2y7wC-4xavA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 4xav GLIOMEDIN
(Mus
musculus) 		4 / 5 THR A 462
ILE A 444
PHE A 491
LEU A 479
 None
 1.31A 3tf1A-4xavA:
undetectable		 3tf1A-4xavA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 4xav GLIOMEDIN
(Mus
musculus) 		5 / 12 PHE A 505
PHE A 491
GLY A 477
LEU A 495
VAL A 446
 None
 1.09A 4wnwA-4xavA:
undetectable		 4wnwA-4xavA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4xav GLIOMEDIN
(Mus
musculus) 		4 / 5 PHE A 415
ILE A 444
GLY A 470
ILE A 434
 None
 0.87A 5dzkB-4xavA:
undetectable
5dzkI-4xavA:
undetectable
5dzkW-4xavA:
undetectable		 5dzkB-4xavA:
21.38
5dzkI-4xavA:
22.22
5dzkW-4xavA:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4xav GLIOMEDIN
(Mus
musculus) 		5 / 9 ILE A 478
LEU A 479
THR A 462
ILE A 460
GLY A 498
 None
 1.35A 5ifuB-4xavA:
undetectable		 5ifuB-4xavA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4xav GLIOMEDIN
(Mus
musculus) 		5 / 12 ASN A 306
PRO A 538
ILE A 304
THR A 302
ILE A 301
 None
 1.10A 6hlpA-4xavA:
undetectable		 6hlpA-4xavA:
16.35