SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 4xax DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1
(Thermus
aquaticus) 		5 / 12 LEU A  94
ALA A  96
LEU A  98
THR A  51
ILE A  44
 None
 1.13A 1crbA-4xaxA:
undetectable		 1crbA-4xaxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 4xax DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1
(Thermus
aquaticus) 		5 / 11 VAL A 355
ILE A  54
LEU A  66
LEU A 367
LEU A 100
 None
 1.20A 2a15A-4xaxA:
1.1		 2a15A-4xaxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 4xax CARD
(Thermus
thermophilus) 		4 / 5 VAL B  49
TYR B  36
VAL B  20
ASP B   8
 None
 1.29A 2x45C-4xaxB:
undetectable		 2x45C-4xaxB:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4xax CARD
(Thermus
thermophilus) 		4 / 8 PRO B 102
ALA B 106
ALA B 109
ILE B  71
 EDO  B 201 (-4.5A)
None
None
None
 0.73A 3dtuC-4xaxB:
undetectable
3dtuD-4xaxB:
undetectable		 3dtuC-4xaxB:
14.39
3dtuD-4xaxB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9X_B_ACTB502_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4xax DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1
CARD
(Thermus
aquaticus;
Thermus
thermophilus) 		4 / 4 LYS B  46
GLU A 110
GLN A  99
TYR B  48
 None
 1.24A 3r9xB-4xaxB:
0.0		 3r9xB-4xaxB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4xax CARD
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1
(Thermus
aquaticus;
Thermus
thermophilus) 		4 / 5 PRO A 369
ASP A 111
ILE A 108
VAL B  38
 None
 1.42A 4hytA-4xaxA:
undetectable		 4hytA-4xaxA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4xax DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1
(Thermus
aquaticus) 		5 / 12 LEU A  94
PHE A 344
ASP A 342
MET A 340
GLY A 337
 None
 1.35A 4j7xA-4xaxA:
undetectable		 4j7xA-4xaxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 4xax DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1
(Thermus
aquaticus) 		5 / 12 LEU A  94
PHE A 344
ASP A 342
MET A 340
GLY A 337
 None
 1.39A 4j7xF-4xaxA:
undetectable		 4j7xF-4xaxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4xax CARD
(Thermus
thermophilus) 		4 / 5 THR B  93
HIS B  90
ALA B 128
ASP B 125
 None
 1.42A 5mfxA-4xaxB:
undetectable		 5mfxA-4xaxB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4xax DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1
CARD
(Thermus
aquaticus;
Thermus
thermophilus) 		5 / 11 ASP A 111
PRO A 369
GLU A 110
ALA B  24
PRO B  50
 None
 1.29A 6bm5A-4xaxA:
undetectable		 6bm5A-4xaxA:
22.08