SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 10 VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
 None
 1.38A 1fk9A-4xb0A:
undetectable		 1fk9A-4xb0A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 9 VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
 None
 1.35A 1ikvA-4xb0A:
undetectable		 1ikvA-4xb0A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 10 VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
 None
 1.39A 1ikwA-4xb0A:
undetectable		 1ikwA-4xb0A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 10 VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
 None
 1.42A 1lw0A-4xb0A:
undetectable		 1lw0A-4xb0A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 9 VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
 None
 1.42A 1lwfA-4xb0A:
undetectable		 1lwfA-4xb0A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 10 VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
 None
 1.41A 1s1uA-4xb0A:
undetectable		 1s1uA-4xb0A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		3 / 3 PRO A 590
LEU A 589
GLN A 502
 None
 0.71A 4pevB-4xb0A:
undetectable		 4pevB-4xb0A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 10 MET A 673
LEU A 669
PRO A 487
LEU A 660
GLN A 496
 None
 1.35A 4zp0A-4xb0A:
undetectable		 4zp0A-4xb0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		4 / 7 ASP A 540
THR A 543
PRO A 557
THR A 559
 None
 1.29A 5b6iA-4xb0A:
undetectable		 5b6iA-4xb0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_C_MMZC503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		4 / 4 TYR A 645
ASN A 671
SER A 667
SER A 666
 None
 1.27A 5gsnC-4xb0A:
0.0		 5gsnC-4xb0A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		3 / 3 ASP A 585
ASN A 624
GLN A 622
 None
 0.78A 5k7uA-4xb0A:
undetectable		 5k7uA-4xb0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 10 VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
 None
 1.42A 6bsgA-4xb0A:
undetectable		 6bsgA-4xb0A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		3 / 3 ALA A 548
PHE A 565
GLN A 564
 None
 0.72A 6eceA-4xb0A:
undetectable		 6eceA-4xb0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 11 MET A 673
LEU A 669
PRO A 487
LEU A 660
GLN A 496
 None
 1.35A 6euqA-4xb0A:
undetectable		 6euqA-4xb0A:
19.05