SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xb1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xb1 319AA LONG
HYPOTHETICAL
HOMOSERINE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A 289
ILE A 149
PRO A 148
LEU A 153
ILE A 165
 None
 1.08A 3hbbA-4xb1A:
undetectable		 3hbbA-4xb1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4xb1 319AA LONG
HYPOTHETICAL
HOMOSERINE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 308
ASN A  33
ILE A   5
SER A   6
VAL A  89
 None
 0.88A 3kpdC-4xb1A:
undetectable		 3kpdC-4xb1A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4xb1 319AA LONG
HYPOTHETICAL
HOMOSERINE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 101
ASP A  90
GLN A  77
VAL A  80
ILE A   7
 None
 1.32A 4drhA-4xb1A:
undetectable		 4drhA-4xb1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4xb1 319AA LONG
HYPOTHETICAL
HOMOSERINE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 ILE A  87
ASN A  86
ILE A  35
VAL A  34
 None
 1.07A 4uy87-4xb1A:
undetectable		 4uy87-4xb1A:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4xb1 319AA LONG
HYPOTHETICAL
HOMOSERINE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 6 ASP A 307
TYR A 101
PRO A 118
TYR A 123
 None
None
None
MPD  A1004 ( 4.8A)
 1.33A 5bmvB-4xb1A:
undetectable		 5bmvB-4xb1A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4xb1 319AA LONG
HYPOTHETICAL
HOMOSERINE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A  19
GLY A 297
ARG A  15
GLY A  11
 None
None
None
NDP  A1001 (-3.4A)
 0.96A 5e26A-4xb1A:
undetectable
5e26B-4xb1A:
undetectable		 5e26A-4xb1A:
22.56
5e26B-4xb1A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 4xb1 319AA LONG
HYPOTHETICAL
HOMOSERINE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 GLU A  19
GLY A 297
ARG A  15
GLY A  11
 None
None
None
NDP  A1001 (-3.4A)
 0.92A 5kprA-4xb1A:
undetectable		 5kprA-4xb1A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4xb1 319AA LONG
HYPOTHETICAL
HOMOSERINE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A  50
SER A  36
GLY A  46
ILE A  44
ILE A   7
 None
 1.05A 6ebzC-4xb1A:
undetectable		 6ebzC-4xb1A:
16.35