SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xb4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AO8_A_MTXA170_1 (DIHYDROFOLATE REDUCTASE)	4xb4	ORANGE CAROTENOID-BINDING PROTEIN (Synechocystis sp. PCC 6803)	5 / 12	LEU A 68 PHE A 109 THR A 97 SER A 100 ALA A 67	None	1.08A	1ao8A-4xb4A: undetectable	1ao8A-4xb4A: 21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VE3_A_REAA1445_1 (PUTATIVE CYTOCHROME P450 120)	4xb4	ORANGE CAROTENOID-BINDING PROTEIN (Synechocystis sp. PCC 6803)	5 / 12	ALA A 67 LEU A 94 ALA A 82 VAL A 122 GLN A 119	None	1.11A	2ve3A-4xb4A: undetectable	2ve3A-4xb4A: 16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HJO_A_EAAA211_1 (GLUTATHIONE S-TRANSFERASE P)	4xb4	ORANGE CAROTENOID-BINDING PROTEIN (Synechocystis sp. PCC 6803)	4 / 8	TYR A 98 GLN A 72 ILE A 40 GLY A 108	None None 45D A 201 (-3.5A) 45D A 201 ( 4.4A)	0.86A	3hjoA-4xb4A: undetectable	3hjoA-4xb4A: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KM6_A_EAAA222_1 (GLUTATHIONE S-TRANSFERASE P)	4xb4	ORANGE CAROTENOID-BINDING PROTEIN (Synechocystis sp. PCC 6803)	5 / 10	TYR A 98 PHE A 109 GLN A 72 ILE A 40 GLY A 108	None None None 45D A 201 (-3.5A) 45D A 201 ( 4.4A)	1.14A	3km6A-4xb4A: undetectable	3km6A-4xb4A: 21.90

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AO8_A_MTXA170_1","DIHYDROFOLATE REDUCTASE","4xb4","ORANGE CAROTENOID-BINDING PROTEIN","Synechocystis sp. PCC 6803",5,"LEU A  68;PHE A 109;THR A  97;SER A 100;ALA A  67","None","1.08A","1ao8A-4xb4A:undetectable","1ao8A-4xb4A:21.39"],["2VE3_A_REAA1445_1","PUTATIVE CYTOCHROME P450 120","4xb4","ORANGE CAROTENOID-BINDING PROTEIN","Synechocystis sp. PCC 6803",5,"ALA A  67;LEU A  94;ALA A  82;VAL A 122;GLN A 119","None","1.11A","2ve3A-4xb4A:undetectable","2ve3A-4xb4A:16.55"],["3HJO_A_EAAA211_1","GLUTATHIONE S-TRANSFERASE P","4xb4","ORANGE CAROTENOID-BINDING PROTEIN","Synechocystis sp. PCC 6803",4,"TYR A  98;GLN A  72;ILE A  40;GLY A 108","None;None;45D A 201 (-3.5A);45D A 201 ( 4.4A)","0.86A","3hjoA-4xb4A:undetectable","3hjoA-4xb4A:21.90"],["3KM6_A_EAAA222_1","GLUTATHIONE S-TRANSFERASE P","4xb4","ORANGE CAROTENOID-BINDING PROTEIN","Synechocystis sp. PCC 6803",5,"TYR A  98;PHE A 109;GLN A  72;ILE A  40;GLY A 108","None;None;None;45D A 201 (-3.5A);45D A 201 ( 4.4A)","1.14A","3km6A-4xb4A:undetectable","3km6A-4xb4A:21.90"]]