SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xba'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4xba APRATAXIN-LIKE
PROTEIN
(Schizosaccharomy
ces
pombe) 		3 / 3 SER A 163
TYR A 166
HIS A 165
 None
 0.79A 2r2vD-4xbaA:
undetectable		 2r2vD-4xbaA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4xba APRATAXIN-LIKE
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 10 ASP A  63
LEU A  73
SER A 142
HIS A 147
HIS A 149
 GMP  A 301 (-2.7A)
None
GMP  A 301 ( 4.0A)
GMP  A 301 (-3.9A)
GMP  A 301 (-4.8A)
 0.42A 3o1cA-4xbaA:
8.0		 3o1cA-4xbaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4xba APRATAXIN-LIKE
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 10 ASP A  63
LEU A  73
SER A 142
HIS A 147
HIS A 149
 GMP  A 301 (-2.7A)
None
GMP  A 301 ( 4.0A)
GMP  A 301 (-3.9A)
GMP  A 301 (-4.8A)
 0.40A 3o1xA-4xbaA:
8.0		 3o1xA-4xbaA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 4xba APRATAXIN-LIKE
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 6 GLU A 220
ASP A 224
ASP A 227
LYS A 228
 None
 1.28A 3pocB-4xbaA:
undetectable		 3pocB-4xbaA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4xba APRATAXIN-LIKE
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 10 ASP A  63
LEU A  73
SER A 142
HIS A 147
HIS A 149
 GMP  A 301 (-2.7A)
None
GMP  A 301 ( 4.0A)
GMP  A 301 (-3.9A)
GMP  A 301 (-4.8A)
 0.40A 3qgzA-4xbaA:
8.1		 3qgzA-4xbaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4xba APRATAXIN-LIKE
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 177
ALA A 139
PHE A 137
LEU A 146
THR A 179
 None
 0.95A 4psyA-4xbaA:
undetectable		 4psyA-4xbaA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4xba APRATAXIN-LIKE
PROTEIN
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS A 155
LYS A  67
PHE A 169
 None
GMP  A 301 (-2.9A)
None
 1.18A 5klaA-4xbaA:
undetectable		 5klaA-4xbaA:
20.76