SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xbi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Plasmodium
falciparum) 		4 / 6 LEU A 193
GLU A 181
THR A 267
LEU A 191
 CRO  A 215 ( 4.8A)
None
None
CRO  A 215 ( 4.9A)
 1.15A 1etb2-4xbiA:
undetectable		 1etb2-4xbiA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Plasmodium
falciparum) 		5 / 10 HIS A 330
LEU A 202
LEU A 213
THR A 211
THR A 212
 None
None
CRO  A 215 ( 4.2A)
CRO  A 215 ( 4.8A)
None
 1.39A 1rj6A-4xbiA:
undetectable		 1rj6A-4xbiA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Plasmodium
falciparum) 		5 / 10 HIS A 330
LEU A 202
LEU A 213
THR A 211
THR A 212
 None
None
CRO  A 215 ( 4.2A)
CRO  A 215 ( 4.8A)
None
 1.37A 1rj6B-4xbiA:
undetectable		 1rj6B-4xbiA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Plasmodium
falciparum;
Aequorea
victoria) 		3 / 3 ASN A 319
LEU A 290
HIS A 318
 None
 0.80A 2q6fB-4xbiA:
undetectable		 2q6fB-4xbiA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Plasmodium
falciparum) 		5 / 12 LEU A 193
LEU A 191
ILE A 163
ALA A 186
PHE A 220
 CRO  A 215 ( 4.8A)
CRO  A 215 ( 4.9A)
None
None
None
 1.17A 2qb4A-4xbiA:
undetectable		 2qb4A-4xbiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Plasmodium
falciparum) 		5 / 9 PHE A 220
VAL A 261
ASN A 270
ILE A 163
PHE A 157
 None
CRO  A 215 ( 4.9A)
CRO  A 215 ( 3.6A)
None
None
 1.20A 3t3rB-4xbiA:
undetectable		 3t3rB-4xbiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Plasmodium
falciparum) 		5 / 9 PHE A 220
VAL A 261
ASN A 270
ILE A 163
PHE A 157
 None
CRO  A 215 ( 4.9A)
CRO  A 215 ( 3.6A)
None
None
 1.24A 3t3rC-4xbiA:
undetectable		 3t3rC-4xbiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Plasmodium
falciparum) 		5 / 10 PHE A 220
VAL A 261
ASN A 270
ILE A 163
PHE A 157
 None
CRO  A 215 ( 4.9A)
CRO  A 215 ( 3.6A)
None
None
 1.19A 3t3rD-4xbiA:
1.5		 3t3rD-4xbiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Plasmodium
falciparum;
Aequorea
victoria) 		4 / 7 ASP A 168
THR A 257
SER A 177
PHE A 176
 None
 1.05A 4ac9C-4xbiA:
undetectable		 4ac9C-4xbiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Plasmodium
falciparum) 		4 / 6 VAL A 204
LEU A 202
LEU A 274
PHE A 314
 None
None
None
CRO  A 215 ( 4.9A)
 1.00A 4o1zA-4xbiA:
1.3		 4o1zA-4xbiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Plasmodium
falciparum;
Aequorea
victoria) 		6 / 12 ALA A 259
LEU A 213
ILE A 163
LEU A 191
TYR A 241
THR A 257
 None
CRO  A 215 ( 4.2A)
None
CRO  A 215 ( 4.9A)
None
None
 1.45A 4qlgB-4xbiA:
undetectable		 4qlgB-4xbiA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Plasmodium
falciparum) 		4 / 7 ILE A 247
ASP A 278
GLY A 253
PHE A 249
 None
 0.92A 5h3aA-4xbiA:
undetectable		 5h3aA-4xbiA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Plasmodium
falciparum;
Aequorea
victoria) 		3 / 3 LEU A 350
ILE A 301
TYR A 241
 None
 0.69A 5uunB-4xbiA:
undetectable		 5uunB-4xbiA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN
(Plasmodium
falciparum;
Aequorea
victoria) 		5 / 11 VAL A  93
SER A  97
THR A  96
VAL A  30
TYR A   7
 None
 1.31A 6dryA-4xbiA:
undetectable		 6dryA-4xbiA:
22.22