SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4xbk DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Lactobacillus
brevis) 		4 / 7 PHE A  68
THR A  15
GLY A 190
THR A 159
 None
 0.97A 2a1mA-4xbkA:
undetectable		 2a1mA-4xbkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4xbk DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Lactobacillus
brevis) 		5 / 12 LEU A  17
GLY A 190
SER A 212
ASP A 172
ALA A 135
 None
 1.09A 2br4F-4xbkA:
undetectable		 2br4F-4xbkA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 4xbk DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Lactobacillus
brevis) 		4 / 7 ILE A  12
ARG A 208
ASP A  94
GLU A  92
 None
 1.04A 2qebA-4xbkA:
undetectable		 2qebA-4xbkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 4xbk DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Lactobacillus
brevis) 		4 / 7 ILE A  12
ARG A 208
ASP A  94
GLU A  92
 None
 1.00A 2qebB-4xbkA:
undetectable		 2qebB-4xbkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4xbk DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Lactobacillus
brevis) 		4 / 6 GLY A  67
THR A 161
GLU A  78
GLU A 101
 None
 1.08A 3fpjA-4xbkA:
undetectable		 3fpjA-4xbkA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4xbk DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Lactobacillus
brevis) 		5 / 12 GLY A 162
GLY A 190
SER A 189
GLY A 210
ASP A  13
 None
 1.02A 3huoB-4xbkA:
undetectable		 3huoB-4xbkA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4xbk DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Lactobacillus
brevis) 		5 / 12 ALA A 206
GLN A   7
SER A 194
ILE A 217
LEU A 218
 None
 1.43A 3ia4A-4xbkA:
undetectable		 3ia4A-4xbkA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4xbk DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Lactobacillus
brevis) 		4 / 7 GLN A   7
THR A   5
LEU A 218
THR A  15
 None
 1.02A 4mbsA-4xbkA:
undetectable		 4mbsA-4xbkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4xbk DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Lactobacillus
brevis) 		4 / 5 VAL A 186
THR A 159
ASN A 134
ASP A 172
 None
 1.15A 5m0iB-4xbkA:
undetectable		 5m0iB-4xbkA:
22.30