SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xbo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		5 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
 None
 1.09A 1fbyA-4xboA:
undetectable		 1fbyA-4xboA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		5 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
 None
 1.05A 1fbyB-4xboA:
undetectable		 1fbyB-4xboA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.12A 1fm6A-4xboA:
undetectable		 1fm6A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.43A 1fm6A-4xboA:
undetectable		 1fm6A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A  35
 None
 1.38A 1fm6A-4xboA:
undetectable		 1fm6A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.11A 1fm6U-4xboA:
undetectable		 1fm6U-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.11A 1fm9A-4xboA:
undetectable		 1fm9A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.44A 1fm9A-4xboA:
undetectable		 1fm9A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A  35
 None
 1.40A 1fm9A-4xboA:
undetectable		 1fm9A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.13A 1k74A-4xboA:
undetectable		 1k74A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.41A 1k74A-4xboA:
undetectable		 1k74A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A  35
 None
 1.38A 1k74A-4xboA:
undetectable		 1k74A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		7 / 12 PHE A 113
GLY A 114
GLY A 119
ILE A 134
SER A 142
LEU A 143
ALA A 148
 SAH  A 301 (-4.9A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
 0.54A 1v2xA-4xboA:
17.6		 1v2xA-4xboA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 11 THR A  79
GLY A 114
GLY A 119
ILE A 134
SER A 142
ALA A 148
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.6A)
 0.77A 1x7pA-4xboA:
16.8
1x7pB-4xboA:
16.9		 1x7pA-4xboA:
24.20
1x7pB-4xboA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 11 THR A  79
GLY A 114
GLY A 119
SER A 142
LEU A 143
ALA A 148
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
 0.75A 1x7pA-4xboA:
16.8
1x7pB-4xboA:
16.9		 1x7pA-4xboA:
24.20
1x7pB-4xboA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 10 THR A  79
GLY A 114
GLY A 119
ILE A 134
LEU A 143
ALA A 148
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
 0.51A 1x7pA-4xboA:
16.8
1x7pB-4xboA:
16.9		 1x7pA-4xboA:
24.20
1x7pB-4xboA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		5 / 12 ALA A  53
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.00A 1xdkA-4xboA:
undetectable		 1xdkA-4xboA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.11A 1xdkE-4xboA:
undetectable		 1xdkE-4xboA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.08A 1xiuA-4xboA:
undetectable		 1xiuA-4xboA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.43A 1xiuA-4xboA:
undetectable		 1xiuA-4xboA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.08A 1xlsA-4xboA:
undetectable		 1xlsA-4xboA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.37A 1xlsA-4xboA:
undetectable		 1xlsA-4xboA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.08A 1xlsB-4xboA:
undetectable		 1xlsB-4xboA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.37A 1xlsB-4xboA:
undetectable		 1xlsB-4xboA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.09A 1xlsC-4xboA:
undetectable		 1xlsC-4xboA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.37A 1xlsC-4xboA:
undetectable		 1xlsC-4xboA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.08A 1xlsD-4xboA:
undetectable		 1xlsD-4xboA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.37A 1xlsD-4xboA:
undetectable		 1xlsD-4xboA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		7 / 11 THR A  79
ALA A  81
GLY A 114
GLY A 119
ILE A 134
LEU A 143
ALA A 148
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
 0.52A 3dcmX-4xboA:
15.8		 3dcmX-4xboA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		5 / 12 ALA A  53
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 0.90A 3dzyA-4xboA:
undetectable		 3dzyA-4xboA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		5 / 12 ALA A  81
GLY A 114
ILE A 134
SER A 142
LEU A 143
 SAH  A 301 (-3.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
 0.85A 3gyqA-4xboA:
16.0
3gyqB-4xboA:
16.0		 3gyqA-4xboA:
20.54
3gyqB-4xboA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		5 / 12 ASN A  17
GLY A 114
GLY A 119
ILE A 134
ASN A 144
 None
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
None
 0.73A 3nk7A-4xboA:
16.2		 3nk7A-4xboA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		5 / 12 ASN A  17
GLY A 114
ILE A 134
SER A 142
ASN A 144
 None
SAH  A 301 (-2.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
None
 0.76A 3nk7A-4xboA:
16.2		 3nk7A-4xboA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		7 / 12 ASN A  17
PHE A 113
GLY A 114
GLY A 119
ILE A 134
SER A 142
LEU A 143
 None
SAH  A 301 (-4.9A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
 0.81A 3nk7B-4xboA:
16.1		 3nk7B-4xboA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		5 / 12 GLY A 114
GLU A 116
GLY A 119
ILE A 134
LEU A 143
 SAH  A 301 (-2.9A)
None
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
 0.79A 3nk7B-4xboA:
16.1		 3nk7B-4xboA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.10A 3oapA-4xboA:
undetectable		 3oapA-4xboA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		4 / 5 LEU A 120
GLY A 114
ILE A 152
VAL A 149
 SAH  A 301 ( 4.8A)
SAH  A 301 (-2.9A)
None
None
 0.87A 3wriA-4xboA:
undetectable		 3wriA-4xboA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		4 / 5 LEU A 120
GLY A 114
ILE A 152
VAL A 149
 SAH  A 301 ( 4.8A)
SAH  A 301 (-2.9A)
None
None
 0.86A 3wriB-4xboA:
undetectable		 3wriB-4xboA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		5 / 11 ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.07A 4nqaA-4xboA:
undetectable		 4nqaA-4xboA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		5 / 12 PHE A 113
LEU A   9
LEU A  30
ALA A 110
VAL A 156
 SAH  A 301 (-4.9A)
None
None
None
None
 1.10A 4wnwB-4xboA:
undetectable		 4wnwB-4xboA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		4 / 5 ARG A  82
SER A 141
SER A 142
SER A  80
 None
None
SAH  A 301 (-3.4A)
SAH  A 301 (-3.2A)
 1.20A 5hswA-4xboA:
undetectable		 5hswA-4xboA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		7 / 12 THR A  79
GLY A 114
GLY A 119
ILE A 134
LEU A 143
LEU A 145
ALA A 148
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
SAH  A 301 ( 4.5A)
SAH  A 301 (-3.6A)
 0.40A 5l0zA-4xboA:
17.4		 5l0zA-4xboA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		7 / 12 THR A  79
GLY A 114
GLY A 119
ILE A 134
SER A 142
LEU A 143
ALA A 148
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
 0.79A 5l0zA-4xboA:
17.4		 5l0zA-4xboA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		7 / 10 THR A  79
GLY A 114
GLY A 119
ILE A 134
LEU A 143
LEU A 145
ALA A 148
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
SAH  A 301 ( 4.5A)
SAH  A 301 (-3.6A)
 0.44A 5l0zB-4xboA:
7.0		 5l0zB-4xboA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		7 / 10 THR A  79
GLY A 114
GLY A 119
ILE A 134
SER A 142
LEU A 143
ALA A 148
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
 0.64A 5l0zB-4xboA:
7.0		 5l0zB-4xboA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.15A 5uanA-4xboA:
undetectable		 5uanA-4xboA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.46A 5uanA-4xboA:
undetectable		 5uanA-4xboA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.07A 5z12B-4xboA:
undetectable		 5z12B-4xboA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.40A 5z12B-4xboA:
undetectable		 5z12B-4xboA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.02A 5z12C-4xboA:
undetectable		 5z12C-4xboA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.40A 6a5yD-4xboA:
undetectable		 6a5yD-4xboA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A  35
 None
 1.32A 6a5yD-4xboA:
undetectable		 6a5yD-4xboA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ
(Escherichia
coli) 		6 / 12 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A  35
 None
 1.40A 6a5zL-4xboA:
undetectable		 6a5zL-4xboA:
15.91