SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4xbz EVDO1
(Micromonospora
carbonacea) 		4 / 5 ASP A 141
HIS A 139
HIS A 217
HIS A 223
 NI  A 401 (-2.7A)
NI  A 401 (-3.6A)
None
NI  A 401 (-3.5A)
 1.06A 1ei6A-4xbzA:
undetectable		 1ei6A-4xbzA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4xbz EVDO1
(Micromonospora
carbonacea) 		5 / 12 LEU A 106
LEU A 216
ILE A  18
GLY A  41
LEU A  43
 None
 1.14A 1g50B-4xbzA:
undetectable		 1g50B-4xbzA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4xbz EVDO1
(Micromonospora
carbonacea) 		5 / 11 LEU A 106
LEU A 216
ILE A  18
GLY A  41
LEU A  43
 None
 1.14A 1g50C-4xbzA:
undetectable		 1g50C-4xbzA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4xbz EVDO1
(Micromonospora
carbonacea) 		5 / 12 LEU A 118
VAL A 114
VAL A  39
LEU A 216
LEU A  42
 None
 1.07A 1mx1E-4xbzA:
undetectable		 1mx1E-4xbzA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 4xbz EVDO1
(Micromonospora
carbonacea) 		5 / 10 ARG A 271
LEU A 106
ILE A 109
ARG A  19
GLY A  22
 None
 1.43A 2bxqA-4xbzA:
undetectable		 2bxqA-4xbzA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4xbz EVDO1
(Micromonospora
carbonacea) 		4 / 8 LEU A 220
ARG A 156
PRO A 251
VAL A 245
 None
 1.07A 2qd2A-4xbzA:
undetectable		 2qd2A-4xbzA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4xbz EVDO1
(Micromonospora
carbonacea) 		5 / 12 LEU A  42
GLY A  41
LEU A  43
ILE A 162
ASP A 165
 None
 1.01A 3gwwA-4xbzA:
undetectable		 3gwwA-4xbzA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4xbz EVDO1
(Micromonospora
carbonacea) 		3 / 3 ARG A 271
PHE A 277
PRO A 275
 None
 0.87A 3zoaB-4xbzA:
undetectable		 3zoaB-4xbzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4xbz EVDO1
(Micromonospora
carbonacea) 		5 / 12 GLY A 155
GLY A 153
ILE A 219
ASP A 159
ILE A 158
 None
None
None
GOL  A 402 (-3.9A)
None
 1.11A 4iv0B-4xbzA:
undetectable		 4iv0B-4xbzA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 4xbz EVDO1
(Micromonospora
carbonacea) 		3 / 3 TYR A 145
GLY A 250
PRO A 251
 None
 0.63A 4qwpA-4xbzA:
undetectable		 4qwpA-4xbzA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4xbz EVDO1
(Micromonospora
carbonacea) 		4 / 5 ARG A  32
GLY A 155
ALA A 154
GLY A  35
 None
 0.95A 4u9uA-4xbzA:
undetectable		 4u9uA-4xbzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4xbz EVDO1
(Micromonospora
carbonacea) 		4 / 5 ARG A  32
GLY A 155
ALA A 154
GLY A  35
 None
 0.90A 4u9uB-4xbzA:
undetectable		 4u9uB-4xbzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 4xbz EVDO1
(Micromonospora
carbonacea) 		5 / 12 ASP A 165
ASP A 141
HIS A 217
ASP A 159
TYR A 237
 None
NI  A 401 (-2.7A)
None
GOL  A 402 (-3.9A)
GOL  A 402 (-3.8A)
 1.33A 5ef8A-4xbzA:
undetectable		 5ef8A-4xbzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4xbz EVDO1
(Micromonospora
carbonacea) 		5 / 5 PRO A  96
ALA A  94
ALA A  54
ILE A  97
LEU A 100
 None
 1.29A 5jncD-4xbzA:
undetectable		 5jncD-4xbzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4xbz EVDO1
(Micromonospora
carbonacea) 		3 / 3 HIS A 307
GLU A  88
TRP A 122
 None
 1.10A 5odqD-4xbzA:
undetectable		 5odqD-4xbzA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4xbz EVDO1
(Micromonospora
carbonacea) 		3 / 3 HIS A 307
GLU A  88
TRP A 122
 None
 1.20A 5odrD-4xbzA:
undetectable		 5odrD-4xbzA:
19.20