SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xcg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 12 ILE B 385
THR B 222
ASP B 221
GLY B 388
GLY B 217
 None
 0.94A 1rjdA-4xcgB:
undetectable		 1rjdA-4xcgB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 12 ILE B 385
THR B 222
ASP B 221
GLY B 388
GLY B 217
 None
 0.94A 1rjdB-4xcgB:
undetectable		 1rjdB-4xcgB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 12 ILE B 385
THR B 222
ASP B 221
GLY B 388
GLY B 217
 None
 0.92A 1rjdC-4xcgB:
undetectable		 1rjdC-4xcgB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		4 / 8 ALA B 445
ALA B 140
LYS B 139
VAL B 438
 None
 0.71A 2bxgA-4xcgB:
undetectable		 2bxgA-4xcgB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 12 ILE B 457
GLY B  53
GLY B 488
ILE B 459
ALA B 461
 None
ADP  B 600 (-3.6A)
None
None
None
 0.89A 2fk8A-4xcgB:
undetectable		 2fk8A-4xcgB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		4 / 6 THR B 337
VAL B 299
VAL B 230
VAL B 370
 None
 0.98A 2z97A-4xcgB:
undetectable		 2z97A-4xcgB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 10 ASN B  72
GLY B 105
ASP B 104
THR B  51
LEU B  48
 None
None
ADP  B 600 (-2.7A)
None
None
 1.28A 3bexA-4xcgB:
undetectable
3bexB-4xcgB:
undetectable		 3bexA-4xcgB:
18.78
3bexB-4xcgB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 11 ASN B  72
GLY B 105
ASP B 104
THR B  51
LEU B  48
 None
None
ADP  B 600 (-2.7A)
None
None
 1.28A 3bexC-4xcgB:
undetectable
3bexD-4xcgB:
undetectable		 3bexC-4xcgB:
18.78
3bexD-4xcgB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 11 THR B  51
LEU B  48
ASN B  72
GLY B 105
ASP B 104
 None
None
None
None
ADP  B 600 (-2.7A)
 1.29A 3bexE-4xcgB:
undetectable
3bexF-4xcgB:
undetectable		 3bexE-4xcgB:
18.78
3bexF-4xcgB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 11 VAL B 359
GLY B 374
LYS B 379
SER B 380
THR B 337
 None
 1.30A 3bjwB-4xcgB:
1.5		 3bjwB-4xcgB:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 11 VAL B 359
GLY B 374
LYS B 379
SER B 380
THR B 337
 None
 1.29A 3bjwE-4xcgB:
undetectable		 3bjwE-4xcgB:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 12 VAL B 359
GLY B 374
LYS B 379
SER B 380
THR B 337
 None
 1.24A 3bjwF-4xcgB:
undetectable		 3bjwF-4xcgB:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 11 VAL B 359
GLY B 374
LYS B 379
SER B 380
THR B 337
 None
 1.31A 3bjwH-4xcgB:
undetectable		 3bjwH-4xcgB:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		4 / 5 ASP B 252
ILE B 345
VAL B 300
THR B 337
 None
 1.18A 3eigA-4xcgB:
undetectable		 3eigA-4xcgB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 12 LEU B 330
ALA B 249
GLY B 354
ASP B 252
LEU B 251
 None
 1.26A 3ou7A-4xcgB:
undetectable		 3ou7A-4xcgB:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 12 LEU B 330
ALA B 249
GLY B 354
ASP B 252
LEU B 251
 None
 1.27A 3ou7D-4xcgB:
undetectable		 3ou7D-4xcgB:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		6 / 12 LEU B 526
THR B 523
GLY B 136
ALA B 445
ALA B 448
LEU B 123
 None
 1.36A 3p5nA-4xcgB:
2.7		 3p5nA-4xcgB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 12 THR B 519
GLY B 136
ALA B 445
ALA B 448
LEU B 123
 None
 1.12A 3p5nA-4xcgB:
2.7		 3p5nA-4xcgB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		6 / 12 LEU B 526
THR B 523
GLY B 136
ALA B 445
ALA B 448
LEU B 123
 None
 1.36A 3p5nB-4xcgB:
2.7		 3p5nB-4xcgB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 12 THR B 519
GLY B 136
ALA B 445
ALA B 448
LEU B 123
 None
 1.11A 3p5nB-4xcgB:
2.7		 3p5nB-4xcgB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		4 / 6 LEU B  78
ALA B 103
ASP B 402
THR B 106
 None
 1.00A 3rozA-4xcgB:
undetectable		 3rozA-4xcgB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		4 / 7 GLY B 178
ALA B 179
ALA B 184
ASP B 185
 None
 0.87A 3ur0B-4xcgB:
undetectable		 3ur0B-4xcgB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		4 / 8 THR B 337
VAL B 299
VAL B 230
VAL B 370
 None
 0.85A 4l4bA-4xcgB:
undetectable		 4l4bA-4xcgB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 12 GLY B 105
ALA B 103
ILE B  77
LEU B  78
ALA B 517
 None
 1.09A 5bw4B-4xcgB:
undetectable		 5bw4B-4xcgB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 11 VAL B 372
LEU B 333
ALA B 246
GLN B 303
VAL B 322
 None
 1.27A 6dryA-4xcgB:
undetectable		 6dryA-4xcgB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4xcg THERMOSOME SUBUNIT
BETA
(Sulfolobus
solfataricus) 		5 / 11 ALA B 375
VAL B 372
ILE B 301
ALA B 249
LEU B 333
 None
 1.13A 6h1lB-4xcgB:
undetectable		 6h1lB-4xcgB:
23.30