SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4xch S-RIBOSYLHOMOCYSTEIN
E LYASE
(Streptococcus
suis) 		4 / 6 LEU A  63
LEU A  62
ILE A 103
ARG A  70
 None
 0.64A 2rlfB-4xchA:
undetectable
2rlfC-4xchA:
undetectable		 2rlfB-4xchA:
12.89
2rlfC-4xchA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4xch S-RIBOSYLHOMOCYSTEIN
E LYASE
(Streptococcus
suis) 		5 / 12 PHE A  80
LEU A  66
LEU A  63
ALA A 111
ARG A  42
 None
 1.22A 2v0mC-4xchA:
undetectable		 2v0mC-4xchA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4xch S-RIBOSYLHOMOCYSTEIN
E LYASE
(Streptococcus
suis) 		4 / 6 LEU A  63
ARG A  83
THR A  84
LEU A  43
 None
 1.10A 2zxwA-4xchA:
undetectable
2zxwJ-4xchA:
undetectable		 2zxwA-4xchA:
16.41
2zxwJ-4xchA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 4xch S-RIBOSYLHOMOCYSTEIN
E LYASE
(Streptococcus
suis) 		3 / 3 PRO A  46
PHE A 155
LYS A  18
 None
 1.14A 3bjwG-4xchA:
undetectable		 3bjwG-4xchA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4xch S-RIBOSYLHOMOCYSTEIN
E LYASE
(Streptococcus
suis) 		3 / 3 HIS A  61
HIS A 133
HIS A  57
 ZN  A 201 (-3.3A)
None
ZN  A 201 (-3.3A)
 0.81A 3s3bA-4xchA:
undetectable		 3s3bA-4xchA:
15.17