SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		3 / 3 ASP A 154
ARG A 157
ILE A 183
 None
 0.87A 1a4gB-4xciA:
undetectable		 1a4gB-4xciA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		4 / 7 LEU A 147
LEU A 193
GLY A 196
LEU A 407
 None
 0.90A 1gtiA-4xciA:
undetectable		 1gtiA-4xciA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 10 ALA A  62
ASP A  86
LEU A 202
ARG A 404
THR A  93
 None
 1.37A 1tdrB-4xciA:
undetectable		 1tdrB-4xciA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		4 / 5 PRO A 192
PRO A 194
GLY A 196
TYR A 198
 None
 1.05A 2jkjD-4xciA:
undetectable		 2jkjD-4xciA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		4 / 5 PRO A 192
PRO A 194
GLY A 196
TYR A 198
 None
 1.05A 2jkjF-4xciA:
undetectable		 2jkjF-4xciA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 12 ALA A 431
TYR A 124
GLY A 123
ALA A 131
LEU A 135
 None
 1.09A 2plwA-4xciA:
undetectable		 2plwA-4xciA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		6 / 12 LEU A 522
THR A 519
GLY A 123
ALA A 441
ALA A 444
LEU A 110
 None
 1.30A 3p5nA-4xciA:
undetectable		 3p5nA-4xciA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		6 / 12 LEU A 522
THR A 519
GLY A 123
ALA A 441
ALA A 444
LEU A 110
 None
 1.29A 3p5nB-4xciA:
undetectable		 3p5nB-4xciA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 11 ALA A  62
ASP A  86
LEU A 202
ARG A 404
THR A  93
 None
 1.45A 4eilA-4xciA:
undetectable		 4eilA-4xciA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 10 ALA A  62
ASP A  86
LEU A 202
ARG A 404
THR A  93
 None
 1.47A 4eilB-4xciA:
undetectable		 4eilB-4xciA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 11 ALA A  62
ASP A  86
LEU A 202
ARG A 404
THR A  93
 None
 1.45A 4eilC-4xciA:
undetectable		 4eilC-4xciA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 11 ALA A  62
ASP A  86
LEU A 202
ARG A 404
THR A  93
 None
 1.45A 4eilE-4xciA:
undetectable		 4eilE-4xciA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 9 ALA A  62
ASP A  86
LEU A 202
ARG A 404
THR A  93
 None
 1.45A 4eilF-4xciA:
undetectable		 4eilF-4xciA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 12 ALA A  62
ASP A  86
LEU A 202
ARG A 404
THR A  93
 None
 1.48A 4kyaB-4xciA:
undetectable		 4kyaB-4xciA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 10 ALA A 127
LEU A 427
ALA A 431
LEU A 449
ALA A 424
 None
 1.06A 4zbrA-4xciA:
undetectable		 4zbrA-4xciA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 10 ALA A 514
LEU A  78
LEU A 103
LEU A 449
ALA A 448
 None
 1.04A 4zbrA-4xciA:
undetectable		 4zbrA-4xciA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 12 GLY A 436
GLU A 443
ILE A 442
GLN A 113
ILE A 115
 None
 1.14A 4zvmA-4xciA:
undetectable
4zvmB-4xciA:
undetectable		 4zvmA-4xciA:
16.90
4zvmB-4xciA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 12 LEU A 132
LEU A 413
GLY A 139
ILE A 419
ALA A 418
 None
 1.29A 5j7wC-4xciA:
undetectable		 5j7wC-4xciA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		4 / 5 LEU A 135
LYS A 507
LEU A 423
GLU A 420
 None
 1.09A 5weaA-4xciA:
undetectable		 5weaA-4xciA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		4 / 8 LEU A  99
LEU A 134
ALA A 131
LEU A 427
 None
 0.87A 5y7pC-4xciA:
undetectable		 5y7pC-4xciA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 12 LEU A 132
LEU A 413
GLY A 139
ILE A 419
ALA A 418
 None
 1.36A 6qxsD-4xciA:
undetectable		 6qxsD-4xciA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4xci THERMOSOME SUBUNIT
ALPHA
(Sulfolobus
solfataricus) 		5 / 12 LEU A 132
LEU A 413
GLY A 139
ILE A 419
ALA A 418
 None
 1.35A 6qyaB-4xciA:
undetectable		 6qyaB-4xciA:
20.07