SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN

(Thermus
thermophilus)
4 / 5 VAL A 159
TYR A 163
VAL A 244
ASP A 191
None
1.30A 2x45A-4xcmA:
undetectable
2x45A-4xcmA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN

(Thermus
thermophilus)
4 / 5 VAL A 159
TYR A 163
VAL A 244
ASP A 191
None
1.29A 2x45C-4xcmA:
undetectable
2x45C-4xcmA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN

(Thermus
thermophilus)
5 / 12 GLY A 221
ILE A 226
GLY A 140
PHE A 158
ALA A 215
None
1.06A 3sueA-4xcmA:
undetectable
3sueA-4xcmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN

(Thermus
thermophilus)
4 / 8 TYR A 234
HIS A 216
TYR A 220
LEU A 151
None
1.32A 3uzzB-4xcmA:
undetectable
3uzzB-4xcmA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN

(Thermus
thermophilus)
5 / 11 PRO A 142
VAL A 224
ALA A 217
SER A 219
GLY A 221
None
1.19A 4mmaA-4xcmA:
undetectable
4mmaA-4xcmA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN

(Thermus
thermophilus)
5 / 10 VAL A 159
VAL A 244
LEU A 192
GLY A 167
LEU A 170
None
1.12A 4ph9A-4xcmA:
undetectable
4ph9A-4xcmA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN

(Thermus
thermophilus)
5 / 10 VAL A 159
VAL A 244
LEU A 192
GLY A 167
LEU A 170
None
1.10A 4ph9B-4xcmA:
undetectable
4ph9B-4xcmA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN

(Thermus
thermophilus)
5 / 10 ALA A 215
LEU A 192
LEU A 209
SER A 129
LEU A 132
None
1.16A 4zbrA-4xcmA:
undetectable
4zbrA-4xcmA:
16.61