SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4xco SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,SIGNAL
SEQUENCE
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU C 471
GLU C 361
ALA C 474
LEU C 470
 None
 1.08A 1eta1-4xcoC:
undetectable		 1eta1-4xcoC:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4xco SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,SIGNAL
SEQUENCE
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU C 471
GLU C 361
ALA C 474
LEU C 470
 None
 1.06A 1eta2-4xcoC:
undetectable		 1eta2-4xcoC:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4xco SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,SIGNAL
SEQUENCE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU C 471
GLU C 361
ALA C 474
LEU C 470
 None
 1.13A 1etb1-4xcoC:
undetectable		 1etb1-4xcoC:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xco SIGNAL RECOGNITION
PARTICLE 19 KDA
PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 8 TYR A   7
VAL A  64
TYR A  53
CYH A  61
 G  M 166 ( 4.7A)
None
G  M 166 ( 4.5A)
None
 1.05A 2xz5A-4xcoA:
undetectable
2xz5C-4xcoA:
undetectable		 2xz5A-4xcoA:
17.62
2xz5C-4xcoA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xco SIGNAL RECOGNITION
PARTICLE 19 KDA
PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 8 TYR A   7
VAL A  64
TYR A  53
CYH A  61
 G  M 166 ( 4.7A)
None
G  M 166 ( 4.5A)
None
 1.05A 2xz5C-4xcoA:
undetectable
2xz5D-4xcoA:
undetectable		 2xz5C-4xcoA:
17.62
2xz5D-4xcoA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4xco SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,SIGNAL
SEQUENCE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU C 362
SER C 363
LEU C 468
PHE C 354
GLY C 353
 None
 0.94A 5jglA-4xcoC:
undetectable		 5jglA-4xcoC:
21.23