SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xcp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ROX_A_T44A128_1 (TRANSTHYRETIN)	4xcp	NEMATODE FATTY ACID RETINOID BINDING PROTEIN (Necator americanus)	4 / 4	LYS A 62 LEU A 59 ALA A 61 LEU A 52	None None None PLM A 202 ( 4.2A)	1.35A	2roxA-4xcpA: undetectable	2roxA-4xcpA: 22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9W_A_VGHA1158_1 (7,8-DIHYDRO-8-OXOGUA NINE TRIPHOSPHATASE)	4xcp	NEMATODE FATTY ACID RETINOID BINDING PROTEIN (Necator americanus)	5 / 12	LEU A 13 PHE A 143 PHE A 132 VAL A 142 PHE A 84	None	1.31A	4c9wA-4xcpA: undetectable	4c9wA-4xcpA: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XO7_B_ASDB402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	4xcp	NEMATODE FATTY ACID RETINOID BINDING PROTEIN (Necator americanus)	4 / 7	TYR A 100 VAL A 36 ILE A 49 LEU A 25	PLM A 201 (-4.5A) None PLM A 202 ( 4.5A) None	1.09A	4xo7B-4xcpA: undetectable	4xo7B-4xcpA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YV5_B_SVRB207_2 (BASIC PHOSPHOLIPASE A2 HOMOLOG 2)	4xcp	NEMATODE FATTY ACID RETINOID BINDING PROTEIN (Necator americanus)	4 / 7	LYS A 147 TYR A 121 LEU A 139 PHE A 136	None	1.26A	4yv5B-4xcpA: undetectable	4yv5B-4xcpA: 18.39

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ROX_A_T44A128_1","TRANSTHYRETIN","4xcp","NEMATODE FATTY ACID RETINOID BINDING PROTEIN","Necator americanus",4,"LYS A  62;LEU A  59;ALA A  61;LEU A  52","None;None;None;PLM A 202 ( 4.2A)","1.35A","2roxA-4xcpA:undetectable","2roxA-4xcpA:22.40"],["4C9W_A_VGHA1158_1","7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE","4xcp","NEMATODE FATTY ACID RETINOID BINDING PROTEIN","Necator americanus",5,"LEU A  13;PHE A 143;PHE A 132;VAL A 142;PHE A  84","None","1.31A","4c9wA-4xcpA:undetectable","4c9wA-4xcpA:22.34"],["4XO7_B_ASDB402_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2","4xcp","NEMATODE FATTY ACID RETINOID BINDING PROTEIN","Necator americanus",4,"TYR A 100;VAL A  36;ILE A  49;LEU A  25","PLM A 201 (-4.5A);None;PLM A 202 ( 4.5A);None","1.09A","4xo7B-4xcpA:undetectable","4xo7B-4xcpA:20.00"],["4YV5_B_SVRB207_2","BASIC PHOSPHOLIPASE A2 HOMOLOG 2","4xcp","NEMATODE FATTY ACID RETINOID BINDING PROTEIN","Necator americanus",4,"LYS A 147;TYR A 121;LEU A 139;PHE A 136","None","1.26A","4yv5B-4xcpA:undetectable","4yv5B-4xcpA:18.39"]]