SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xct'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 12 ILE A 166
ALA A 191
PHE A 228
PHE A 221
ILE A 168
 None
 1.08A 1cd2A-4xctA:
undetectable		 1cd2A-4xctA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 11 ILE A 166
ALA A 191
PHE A 228
LEU A 220
ILE A 168
 None
 1.06A 1dg5A-4xctA:
undetectable		 1dg5A-4xctA:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 5 HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.17A 1os2A-4xctA:
28.6		 1os2A-4xctA:
49.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.13A 1os2D-4xctA:
28.7		 1os2D-4xctA:
49.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.13A 1uttA-4xctA:
29.1		 1uttA-4xctA:
50.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.11A 1utzA-4xctA:
29.3		 1utzA-4xctA:
50.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.10A 1utzB-4xctA:
29.5		 1utzB-4xctA:
50.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 6 HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.16A 1y93A-4xctA:
29.1		 1y93A-4xctA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 236
HIS A 230
HIS A 226
 ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.2A)
 0.72A 2einN-4xctA:
undetectable		 2einN-4xctA:
14.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.08A 2hu6A-4xctA:
29.4		 2hu6A-4xctA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 9 HIS A 226
GLU A 227
HIS A 230
HIS A 236
MET A 247
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
None
 0.52A 2jihA-4xctA:
11.0		 2jihA-4xctA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 9 LEU A 188
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 N73  A 301 (-4.4A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.43A 2jihA-4xctA:
11.0		 2jihA-4xctA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 8 LEU A 188
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 N73  A 301 (-4.4A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.35A 2jihB-4xctA:
11.3		 2jihB-4xctA:
19.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 6 HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.32A 2ow9A-4xctA:
28.0		 2ow9A-4xctA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 6 LEU A 187
HIS A 190
HIS A 226
HIS A 230
HIS A 236
 N73  A 301 (-4.0A)
ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.75A 2ow9A-4xctA:
28.0		 2ow9A-4xctA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.13A 2ow9B-4xctA:
28.2		 2ow9B-4xctA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.18A 2ozrC-4xctA:
28.0		 2ozrC-4xctA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.24A 2ozrD-4xctA:
28.2		 2ozrD-4xctA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.29A 2ozrE-4xctA:
28.4		 2ozrE-4xctA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 226
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.28A 2ozrF-4xctA:
27.9		 2ozrF-4xctA:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 7 ILE A 166
LEU A 232
GLY A 229
PHE A 228
 None
 0.88A 2tsrA-4xctA:
undetectable		 2tsrA-4xctA:
17.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 190
GLU A 227
HIS A 230
 ZN  A 303 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
 0.48A 3ba0A-4xctA:
26.1		 3ba0A-4xctA:
50.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 236
HIS A 230
HIS A 226
 ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.2A)
 0.75A 3bvdA-4xctA:
undetectable		 3bvdA-4xctA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 7 GLY A 195
HIS A 118
ASP A 165
ILE A 166
 GOL  A 313 (-3.6A)
GOL  A 313 ( 3.9A)
None
None
 0.86A 3fi0P-4xctA:
undetectable		 3fi0P-4xctA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 9 LEU A 188
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 N73  A 301 (-4.4A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.47A 3hy7A-4xctA:
11.4		 3hy7A-4xctA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 9 LEU A 188
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 N73  A 301 (-4.4A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.38A 3hy7B-4xctA:
11.3		 3hy7B-4xctA:
23.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.15A 3kecA-4xctA:
27.9		 3kecA-4xctA:
57.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 LEU A 187
HIS A 226
HIS A 230
HIS A 236
 N73  A 301 (-4.0A)
ZN  A 302 ( 3.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.74A 3kecA-4xctA:
27.9		 3kecA-4xctA:
57.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 226
GLU A 227
HIS A 230
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
 0.11A 3kecB-4xctA:
28.1		 3kecB-4xctA:
57.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 5 HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.29A 3likA-4xctA:
29.4		 3likA-4xctA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.09A 3lilA-4xctA:
29.5		 3lilA-4xctA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.14A 3ljgA-4xctA:
29.3		 3ljgA-4xctA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 5 HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.27A 3lkaA-4xctA:
29.2		 3lkaA-4xctA:
50.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 236
HIS A 230
HIS A 226
 ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.2A)
 0.76A 3s38A-4xctA:
undetectable		 3s38A-4xctA:
13.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 6 HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.35A 4a7bA-4xctA:
28.2		 4a7bA-4xctA:
57.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 6 LEU A 187
HIS A 190
HIS A 226
HIS A 230
HIS A 236
 N73  A 301 (-4.0A)
ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.78A 4a7bA-4xctA:
28.2		 4a7bA-4xctA:
57.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 5 LEU A 187
HIS A 190
HIS A 226
GLU A 227
HIS A 230
 N73  A 301 (-4.0A)
ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
 0.67A 4a7bB-4xctA:
28.3		 4a7bB-4xctA:
57.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 ASP A 259
LYS A 258
ASP A 260
 None
 0.84A 4a7tA-4xctA:
undetectable		 4a7tA-4xctA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 11 ILE A 168
ASP A 201
ILE A 166
GLY A 200
GLY A 229
 None
CA  A 305 (-2.9A)
None
CA  A 305 ( 4.2A)
None
 1.08A 4ac9B-4xctA:
undetectable
4ac9C-4xctA:
undetectable		 4ac9B-4xctA:
14.58
4ac9C-4xctA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 10 ILE A 166
ALA A 191
PHE A 228
LEU A 220
ILE A 168
 None
 1.08A 4km0A-4xctA:
undetectable		 4km0A-4xctA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 12 ILE A 166
ALA A 191
PHE A 228
LEU A 220
ILE A 168
 None
 1.09A 4km0B-4xctA:
undetectable		 4km0B-4xctA:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.09A 5n5jA-4xctA:
29.5		 5n5jA-4xctA:
50.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.10A 5n5kA-4xctA:
29.3		 5n5kA-4xctA:
50.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 236
HIS A 230
HIS A 226
 ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.2A)
 0.69A 5x1fN-4xctA:
undetectable		 5x1fN-4xctA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 190
HIS A 175
HIS A 203
PHE A 192
 ZN  A 303 ( 3.2A)
ZN  A 303 (-3.1A)
ZN  A 303 (-3.1A)
DMS  A 307 (-4.2A)
 1.28A 5zrdC-4xctA:
undetectable		 5zrdC-4xctA:
12.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 TYR A 179
HIS A 190
PHE A 192
 DMS  A 307 ( 3.9A)
ZN  A 303 ( 3.2A)
DMS  A 307 (-4.2A)
 0.10A 6esmA-4xctA:
32.9		 6esmA-4xctA:
100.00