SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xcv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		3 / 3 ASN A  33
PHE A 293
VAL A  18
 None
 0.85A 1kijA-4xcvA:
undetectable		 1kijA-4xcvA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		5 / 11 LEU A  66
GLY A  73
GLY A  72
ILE A  11
ILE A  69
 None
 1.02A 1sduA-4xcvA:
undetectable		 1sduA-4xcvA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		5 / 12 GLU A 304
PHE A 303
GLN A 299
PRO A  89
VAL A   7
 None
 1.25A 1u72A-4xcvA:
undetectable		 1u72A-4xcvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 6 ARG A 315
ILE A  80
GLY A 318
ALA A 317
 None
 0.97A 1wmqA-4xcvA:
undetectable		 1wmqA-4xcvA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 6 ARG A 315
ILE A  80
GLY A 318
ALA A 317
 None
 0.96A 1wmqB-4xcvA:
undetectable		 1wmqB-4xcvA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 6 ARG A 315
ILE A  80
GLY A 318
ALA A 317
 None
 0.96A 1wpuA-4xcvA:
undetectable		 1wpuA-4xcvA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 6 ARG A 315
ILE A  80
GLY A 318
ALA A 317
 None
 0.96A 1wpuB-4xcvA:
undetectable		 1wpuB-4xcvA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 6 ARG A 315
ILE A  80
GLY A 318
ALA A 317
 None
 0.98A 1wrqA-4xcvA:
undetectable		 1wrqA-4xcvA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 6 ARG A 315
ILE A  80
GLY A 318
ALA A 317
 None
 0.99A 1wrqB-4xcvA:
undetectable		 1wrqB-4xcvA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		5 / 12 LEU A  66
GLY A  73
GLY A  72
ILE A  11
ILE A  69
 None
 1.07A 2r5pA-4xcvA:
undetectable		 2r5pA-4xcvA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		5 / 12 PHE A 293
LEU A  51
LEU A   8
ALA A  25
GLU A 289
 None
 1.19A 3cwkA-4xcvA:
undetectable		 3cwkA-4xcvA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		5 / 11 LEU A  66
ILE A  90
GLY A  72
ILE A  11
ILE A  69
 None
 1.12A 3ebzA-4xcvA:
undetectable		 3ebzA-4xcvA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		5 / 12 ALA A 232
HIS A 113
LEU A 271
ALA A 246
LEU A 252
 NDP  A 401 (-4.0A)
None
None
None
None
 1.03A 3ozuA-4xcvA:
2.7		 3ozuA-4xcvA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 5 GLY A 222
ASP A 221
ARG A 220
MET A 145
 None
 1.30A 3qx3A-4xcvA:
undetectable		 3qx3A-4xcvA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 5 GLY A 222
ASP A 221
ARG A 220
MET A 145
 None
 1.33A 3qx3B-4xcvA:
undetectable		 3qx3B-4xcvA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		5 / 11 LEU A  66
ILE A  90
GLY A  72
ILE A  11
ILE A  69
 None
 1.09A 3s53B-4xcvA:
undetectable		 3s53B-4xcvA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		5 / 12 LEU A  51
VAL A   9
PHE A  26
VAL A 296
PHE A  13
 None
 1.38A 3u9fH-4xcvA:
undetectable
3u9fI-4xcvA:
undetectable		 3u9fH-4xcvA:
21.17
3u9fI-4xcvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		5 / 11 LEU A  51
VAL A   9
PHE A  26
VAL A 296
PHE A  13
 None
 1.36A 3u9fN-4xcvA:
undetectable
3u9fO-4xcvA:
undetectable		 3u9fN-4xcvA:
21.17
3u9fO-4xcvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 6 VAL A  18
ASP A  19
SER A  31
ALA A  38
 None
 1.21A 4nedA-4xcvA:
undetectable		 4nedA-4xcvA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_C_CLQC1079_0
(SAPOSIN-B)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 5 ARG A 115
MET A 161
GLU A 136
LEU A 114
 None
 1.32A 4v2oA-4xcvA:
undetectable
4v2oC-4xcvA:
undetectable		 4v2oA-4xcvA:
17.10
4v2oC-4xcvA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 5 HIS A 113
ASP A 121
GLY A 119
ASN A 276
 None
 1.29A 5x7pB-4xcvA:
undetectable		 5x7pB-4xcvA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 5 GLY A 222
ASP A 221
ARG A 220
MET A 145
 None
 1.24A 5zrfB-4xcvA:
undetectable		 5zrfB-4xcvA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		4 / 4 GLY A 222
ASP A 221
ARG A 220
MET A 145
 None
 1.24A 5zrfA-4xcvA:
1.8		 5zrfA-4xcvA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE
(Rhizobium
etli) 		5 / 12 PHE A 181
TYR A 210
LEU A 147
GLY A 146
ALA A 154
 None
None
NDP  A 401 (-4.9A)
NDP  A 401 ( 3.7A)
None
 1.27A 6r2eH-4xcvA:
undetectable		 6r2eH-4xcvA:
22.59