SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4xcw MOLYBDOPTERIN
ADENYLYLTRANSFERASE
(Helicobacter
pylori) 		6 / 12 LEU A  69
VAL A  71
GLN A 119
ILE A 130
ILE A 150
ALA A 149
 None
 1.20A 4ltwA-4xcwA:
undetectable		 4ltwA-4xcwA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4xcw MOLYBDOPTERIN
ADENYLYLTRANSFERASE
(Helicobacter
pylori) 		4 / 4 CYH A 153
LEU A 128
LEU A  96
ALA A 121
 None
 1.13A 5hpuA-4xcwA:
undetectable
5hpuB-4xcwA:
undetectable		 5hpuA-4xcwA:
10.24
5hpuB-4xcwA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xcw MOLYBDOPTERIN
ADENYLYLTRANSFERASE
(Helicobacter
pylori) 		4 / 4 SER A  12
ALA A  11
GLN A 119
THR A  84
 None
 1.32A 5n0rA-4xcwA:
undetectable		 5n0rA-4xcwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xcw MOLYBDOPTERIN
ADENYLYLTRANSFERASE
(Helicobacter
pylori) 		4 / 4 SER A  12
ALA A  11
GLN A 119
THR A  84
 None
 1.32A 5n0sA-4xcwA:
undetectable		 5n0sA-4xcwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xcw MOLYBDOPTERIN
ADENYLYLTRANSFERASE
(Helicobacter
pylori) 		4 / 5 SER A  12
ALA A  11
GLN A 119
THR A  84
 None
 1.30A 5n0tA-4xcwA:
undetectable		 5n0tA-4xcwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xcw MOLYBDOPTERIN
ADENYLYLTRANSFERASE
(Helicobacter
pylori) 		4 / 4 SER A  12
ALA A  11
GLN A 119
THR A  84
 None
 1.32A 5n0wA-4xcwA:
undetectable		 5n0wA-4xcwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xcw MOLYBDOPTERIN
ADENYLYLTRANSFERASE
(Helicobacter
pylori) 		4 / 5 SER A  12
ALA A  11
GLN A 119
THR A  84
 None
 1.31A 5n0wB-4xcwA:
undetectable		 5n0wB-4xcwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xcw MOLYBDOPTERIN
ADENYLYLTRANSFERASE
(Helicobacter
pylori) 		4 / 4 SER A  12
ALA A  11
GLN A 119
THR A  84
 None
 1.31A 5n0xA-4xcwA:
undetectable		 5n0xA-4xcwA:
16.79