SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xd0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		5 / 11 LEU A 122
THR A 121
ILE A   5
ILE A  11
VAL A  15
 None
 1.12A 1pkvA-4xd0A:
undetectable
1pkvB-4xd0A:
undetectable		 1pkvA-4xd0A:
12.84
1pkvB-4xd0A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		5 / 11 ILE A  11
VAL A  15
LEU A 122
THR A 121
ILE A   5
 None
 1.12A 1pkvA-4xd0A:
undetectable
1pkvB-4xd0A:
undetectable		 1pkvA-4xd0A:
12.84
1pkvB-4xd0A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		4 / 7 SER A 243
PRO A 245
SER A 241
LEU A 267
 None
K  A 404 ( 4.8A)
K  A 404 (-4.9A)
None
 1.06A 2hdnE-4xd0A:
undetectable
2hdnF-4xd0A:
undetectable
2hdnH-4xd0A:
undetectable		 2hdnE-4xd0A:
8.49
2hdnF-4xd0A:
21.01
2hdnH-4xd0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		4 / 7 SER A 241
LEU A 267
SER A 243
PRO A 245
 K  A 404 (-4.9A)
None
None
K  A 404 ( 4.8A)
 1.05A 2hdnF-4xd0A:
undetectable
2hdnG-4xd0A:
undetectable
2hdnH-4xd0A:
undetectable		 2hdnF-4xd0A:
21.01
2hdnG-4xd0A:
8.49
2hdnH-4xd0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		5 / 12 LEU A 365
ILE A 361
LEU A 360
ALA A 312
PHE A 396
 None
 1.13A 2qo6A-4xd0A:
undetectable		 2qo6A-4xd0A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		5 / 12 ILE A   5
LEU A  28
ILE A  70
VAL A 163
LEU A 167
 None
 1.11A 3a51C-4xd0A:
undetectable		 3a51C-4xd0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		4 / 4 GLU A  75
GLY A 159
THR A 160
GLU A 161
 T3F  A 403 (-3.4A)
None
None
None
 1.00A 3e9xA-4xd0A:
undetectable		 3e9xA-4xd0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		5 / 9 ILE A  90
ILE A  79
PHE A  76
LYS A   8
GLY A   7
 None
FON  A 402 (-4.0A)
None
T3F  A 403 (-3.2A)
None
 1.30A 3sj4X-4xd0A:
undetectable		 3sj4X-4xd0A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		4 / 8 THR A  16
GLY A   7
PHE A  46
SER A  73
 None
None
None
FON  A 402 ( 4.0A)
 1.04A 3tzfB-4xd0A:
undetectable		 3tzfB-4xd0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		4 / 6 GLN A  43
PHE A  42
ILE A 156
PHE A 218
 None
None
None
T3F  A 403 (-4.0A)
 1.24A 4fgkA-4xd0A:
3.5		 4fgkA-4xd0A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		5 / 8 ILE A  90
ILE A  79
PHE A  76
LYS A   8
GLY A   7
 None
FON  A 402 (-4.0A)
None
T3F  A 403 (-3.2A)
None
 1.37A 4hdlA-4xd0A:
undetectable		 4hdlA-4xd0A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		5 / 9 LEU A 363
GLY A 364
LEU A 365
LEU A 357
GLU A 321
 None
 1.23A 5dqfA-4xd0A:
undetectable		 5dqfA-4xd0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		3 / 3 SER A 189
TYR A 188
TYR A 187
 FON  A 402 ( 4.6A)
None
None
 0.88A 5lakA-4xd0A:
undetectable
5lakI-4xd0A:
undetectable		 5lakA-4xd0A:
22.54
5lakI-4xd0A:
1.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		3 / 3 SER A 189
TYR A 188
TYR A 187
 FON  A 402 ( 4.6A)
None
None
 0.83A 5lakC-4xd0A:
undetectable
5lakJ-4xd0A:
undetectable		 5lakC-4xd0A:
22.54
5lakJ-4xd0A:
1.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		3 / 3 TYR A 188
ALA A 100
TYR A 101
 None
 0.77A 5uunB-4xd0A:
undetectable		 5uunB-4xd0A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		4 / 6 LEU A 369
THR A 339
GLY A 337
ARG A 333
 None
 1.30A 6gtqB-4xd0A:
undetectable
6gtqD-4xd0A:
undetectable		 6gtqB-4xd0A:
18.99
6gtqD-4xd0A:
7.23