SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xd9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
(Aspergillus
nidulans) 		4 / 5 THR A 197
GLU A 195
HIS A 205
HIS A 161
 None
 1.21A 1d4fA-4xd9A:
undetectable		 1d4fA-4xd9A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
(Aspergillus
nidulans) 		4 / 5 THR A 197
GLU A 195
HIS A 205
HIS A 161
 None
 1.19A 1d4fD-4xd9A:
undetectable		 1d4fD-4xd9A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 4xd9 RIBOSOME BIOGENESIS
PROTEIN (RRS1),
PUTATIVE
(AFU_ORTHOLOGUE
AFUA_7G04430)
RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
(Aspergillus
nidulans) 		4 / 5 GLU A 241
ARG A 105
ASP A 170
THR B  93
 None
 1.43A 1rrjA-4xd9A:
undetectable		 1rrjA-4xd9A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
(Aspergillus
nidulans) 		5 / 12 HIS A  68
LEU A 101
GLY A  91
GLY A  35
SER A  36
 None
 0.95A 3cjtG-4xd9A:
undetectable		 3cjtG-4xd9A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
RIBOSOME BIOGENESIS
PROTEIN (RRS1),
PUTATIVE
(AFU_ORTHOLOGUE
AFUA_7G04430)
(Aspergillus
nidulans;
Aspergillus
nidulans) 		4 / 4 GLY A 150
GLU A 195
ASP A 155
ASP B  40
 None
 1.10A 3mb5A-4xd9A:
undetectable		 3mb5A-4xd9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
(Aspergillus
nidulans) 		3 / 3 VAL A  30
SER A  57
THR A  53
 None
 0.46A 4luhA-4xd9A:
undetectable		 4luhA-4xd9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4xd9 RIBOSOME BIOGENESIS
PROTEIN (RRS1),
PUTATIVE
(AFU_ORTHOLOGUE
AFUA_7G04430)
RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
(Aspergillus
nidulans) 		4 / 6 ASP A 122
GLU A 126
ASN B  53
ARG A 207
 None
 1.42A 4ntxA-4xd9A:
undetectable
4ntxC-4xd9A:
undetectable		 4ntxA-4xd9A:
21.14
4ntxC-4xd9A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
(Aspergillus
nidulans) 		4 / 7 ALA A 115
LEU A 117
LEU A 118
ILE A 239
 None
 0.81A 4ubsA-4xd9A:
undetectable		 4ubsA-4xd9A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
(Aspergillus
nidulans) 		4 / 8 LEU A 206
LEU A 171
MET A 167
LEU A 101
 None
 0.99A 5dxeA-4xd9A:
undetectable		 5dxeA-4xd9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
(Aspergillus
nidulans) 		4 / 5 LEU A 171
LEU A 164
PHE A 172
LEU A 206
 None
 0.83A 5gtrA-4xd9A:
undetectable		 5gtrA-4xd9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
(Aspergillus
nidulans) 		4 / 8 LEU A 206
LEU A 171
MET A 167
LEU A 101
 None
 1.00A 6cbzA-4xd9A:
undetectable		 6cbzA-4xd9A:
14.70