SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xdi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4xdi CHLAMYDOMONAS
REINHARDTII THB1
(Chlamydomonas
reinhardtii) 		4 / 7 LEU A  98
LEU A 105
GLY A 106
MET A 116
 None
 0.81A 1n13G-4xdiA:
undetectable
1n13J-4xdiA:
undetectable		 1n13G-4xdiA:
18.52
1n13J-4xdiA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4xdi CHLAMYDOMONAS
REINHARDTII THB1
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 102
LEU A 105
LEU A 111
ALA A 115
ILE A 118
 None
 0.84A 1tw4A-4xdiA:
undetectable		 1tw4A-4xdiA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4xdi CHLAMYDOMONAS
REINHARDTII THB1
(Chlamydomonas
reinhardtii) 		5 / 10 TYR A  12
ALA A  20
ALA A  24
THR A 101
LEU A  98
 None
 1.31A 2wuzA-4xdiA:
undetectable		 2wuzA-4xdiA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4xdi CHLAMYDOMONAS
REINHARDTII THB1
(Chlamydomonas
reinhardtii) 		5 / 10 TYR A  12
ALA A  20
ALA A  24
THR A 101
LEU A  98
 None
 1.32A 2wuzB-4xdiA:
undetectable		 2wuzB-4xdiA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WV2_A_TPFA1_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4xdi CHLAMYDOMONAS
REINHARDTII THB1
(Chlamydomonas
reinhardtii) 		5 / 9 TYR A  12
ALA A  20
ALA A  24
THR A 101
LEU A  98
 None
 1.43A 2wv2A-4xdiA:
undetectable		 2wv2A-4xdiA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4xdi CHLAMYDOMONAS
REINHARDTII THB1
(Chlamydomonas
reinhardtii) 		5 / 12 ARG A  14
LEU A 105
SER A 100
GLU A 114
ALA A 115
 None
 1.14A 3kkzA-4xdiA:
undetectable		 3kkzA-4xdiA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4xdi CHLAMYDOMONAS
REINHARDTII THB1
(Chlamydomonas
reinhardtii) 		3 / 3 MET A  47
ASP A  26
PHE A  28
 None
 1.07A 4xeyA-4xdiA:
undetectable		 4xeyA-4xdiA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4xdi CHLAMYDOMONAS
REINHARDTII THB1
(Chlamydomonas
reinhardtii) 		5 / 10 LEU A  73
ALA A 122
GLU A  83
PHE A  42
VAL A  94
 HEM  A 201 (-4.6A)
HEM  A 201 (-3.3A)
None
HEM  A 201 (-3.8A)
HEM  A 201 (-4.2A)
 1.12A 6b89A-4xdiA:
0.9		 6b89A-4xdiA:
23.44