SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xdo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		5 / 12 ILE A  16
ALA A  41
GLN A 264
ILE A  50
PRO A  51
 None
 0.95A 1dhfA-4xdoA:
undetectable		 1dhfA-4xdoA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		4 / 6 ASN A 151
TRP A  55
HIS A 203
TYR A 201
 None
 1.40A 1mxdA-4xdoA:
undetectable		 1mxdA-4xdoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		5 / 10 ALA A 288
TRP A 210
LEU A 202
GLY A 267
PHE A 269
 None
 1.40A 1ruaH-4xdoA:
undetectable
1ruaL-4xdoA:
undetectable		 1ruaH-4xdoA:
20.00
1ruaL-4xdoA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		4 / 5 VAL A 173
ASN A 292
VAL A 315
ILE A 317
 None
 1.02A 1z2bC-4xdoA:
undetectable		 1z2bC-4xdoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		4 / 5 PRO A 132
GLY A 284
ASN A 282
GLY A 181
 None
 1.13A 1zlqA-4xdoA:
undetectable		 1zlqA-4xdoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		5 / 11 GLY A 218
TYR A 301
ARG A 297
VAL A 304
TYR A 275
 None
 1.44A 2fl5A-4xdoA:
undetectable
2fl5B-4xdoA:
undetectable
2fl5F-4xdoA:
undetectable		 2fl5A-4xdoA:
21.39
2fl5B-4xdoA:
22.15
2fl5F-4xdoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		4 / 7 TYR A 277
THR A 191
TYR A 275
ASP A 193
 None
 1.09A 2g70A-4xdoA:
undetectable		 2g70A-4xdoA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		4 / 8 TYR A  32
LEU A  33
LYS A  39
ALA A  41
 None
 1.04A 2wekA-4xdoA:
undetectable		 2wekA-4xdoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		3 / 3 LEU A 119
TRP A 210
TYR A 123
 None
 0.95A 3aicA-4xdoA:
undetectable		 3aicA-4xdoA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		3 / 3 LEU A 119
TRP A 210
TYR A 123
 None
 0.92A 3aicB-4xdoA:
undetectable		 3aicB-4xdoA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		3 / 3 LEU A 119
TRP A 210
TYR A 123
 None
 0.93A 3aicE-4xdoA:
undetectable		 3aicE-4xdoA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		3 / 3 LEU A 119
TRP A 210
TYR A 123
 None
 0.96A 3aicF-4xdoA:
undetectable		 3aicF-4xdoA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		3 / 3 LEU A 119
TRP A 210
TYR A 123
 None
 0.92A 3aicG-4xdoA:
undetectable		 3aicG-4xdoA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		3 / 3 LEU A 119
TRP A 210
TYR A 123
 None
 0.90A 3aicH-4xdoA:
undetectable		 3aicH-4xdoA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		3 / 3 LYS A 243
ILE A 271
PHE A 269
 FE  A 402 ( 4.8A)
None
None
 0.89A 3j7zS-4xdoA:
undetectable
3j7za-4xdoA:
undetectable		 3j7zS-4xdoA:
16.20
3j7za-4xdoA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		5 / 12 GLY A 302
ALA A 305
ARG A 330
ILE A 299
LEU A 196
 None
 1.27A 4azsA-4xdoA:
undetectable		 4azsA-4xdoA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		3 / 3 LYS A  91
LYS A 107
ALA A 131
 None
 1.40A 4ot2A-4xdoA:
undetectable		 4ot2A-4xdoA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		3 / 3 MET A  94
GLU A  98
LEU A 102
 None
 0.63A 4v2oB-4xdoA:
undetectable		 4v2oB-4xdoA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		5 / 12 GLU A 268
GLY A 267
ALA A 266
SER A 209
TYR A 116
 None
 1.38A 5cprB-4xdoA:
undetectable		 5cprB-4xdoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		5 / 12 TYR A 211
THR A 186
GLY A  82
VAL A 251
LEU A 127
 None
 1.46A 5jo9A-4xdoA:
undetectable		 5jo9A-4xdoA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		5 / 9 ILE A  69
PHE A  99
ASN A  88
ASP A 137
ILE A  73
 None
 1.43A 5lg3B-4xdoA:
undetectable		 5lg3B-4xdoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		5 / 12 GLY A  82
ILE A 247
THR A  85
VAL A  77
LEU A 224
 None
 1.32A 5nz0A-4xdoA:
undetectable		 5nz0A-4xdoA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		4 / 6 GLU A 222
ALA A 238
LEU A 240
TYR A 277
 None
 0.19A 5phhA-4xdoA:
44.9		 5phhA-4xdoA:
64.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C
(Homo
sapiens) 		4 / 7 ARG A 297
LEU A 159
TYR A 197
VAL A 158
 None
 1.30A 6g2pA-4xdoA:
undetectable		 6g2pA-4xdoA:
19.68