SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xdq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 TRP A 149
ALA A 180
VAL A 177
 EDO  A 308 (-3.6A)
None
None
 0.73A 1c4dC-4xdqA:
undetectable
1c4dD-4xdqA:
undetectable		 1c4dC-4xdqA:
5.67
1c4dD-4xdqA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 TRP A 106
TRP A 114
GLY A 111
PRO A 190
 None
 1.35A 1dedA-4xdqA:
undetectable		 1dedA-4xdqA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 GLY A 126
TYR A 150
ALA A 127
GLU A 148
 None
None
None
EDO  A 307 (-3.4A)
 0.88A 1dmaA-4xdqA:
undetectable		 1dmaA-4xdqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 PRO A 228
ASP A  27
ASP A  38
TRP A  42
 None
 1.33A 1hpkA-4xdqA:
undetectable		 1hpkA-4xdqA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 VAL A 177
TRP A 149
TRP A 128
GLU A 148
 None
EDO  A 308 (-3.6A)
EDO  A 307 (-4.0A)
EDO  A 307 (-3.4A)
 1.18A 1om5A-4xdqA:
undetectable
1om5B-4xdqA:
undetectable		 1om5A-4xdqA:
21.18
1om5B-4xdqA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TRP A 128
GLU A 148
VAL A 177
TRP A 149
 EDO  A 307 (-4.0A)
EDO  A 307 (-3.4A)
None
EDO  A 308 (-3.6A)
 1.06A 1rs6A-4xdqA:
undetectable
1rs6B-4xdqA:
undetectable		 1rs6A-4xdqA:
21.18
1rs6B-4xdqA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TYR A  66
VAL A 229
TRP A 128
GLU A  49
 None
None
EDO  A 307 (-4.0A)
None
 1.24A 1s3zA-4xdqA:
undetectable
1s3zB-4xdqA:
undetectable		 1s3zA-4xdqA:
20.74
1s3zB-4xdqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 ASP A 254
ASP A  27
ASN A  78
 CD  A 302 ( 2.3A)
None
None
 0.83A 2bm9D-4xdqA:
undetectable		 2bm9D-4xdqA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 VAL A 177
TRP A 149
TRP A 128
GLU A 148
 None
EDO  A 308 (-3.6A)
EDO  A 307 (-4.0A)
EDO  A 307 (-3.4A)
 1.16A 2g6hA-4xdqA:
undetectable
2g6hB-4xdqA:
undetectable		 2g6hA-4xdqA:
21.23
2g6hB-4xdqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 ARG A 117
ASP A  30
ASN A  80
 BEZ  A 306 (-3.5A)
None
None
 0.75A 2zzmA-4xdqA:
undetectable		 2zzmA-4xdqA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TRP A 128
GLU A 148
VAL A 177
TRP A 149
 EDO  A 307 (-4.0A)
EDO  A 307 (-3.4A)
None
EDO  A 308 (-3.6A)
 1.01A 3b3pA-4xdqA:
undetectable
3b3pB-4xdqA:
undetectable		 3b3pA-4xdqA:
21.13
3b3pB-4xdqA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 GLY A 192
PHE A 147
PHE A 195
PHE A 206
 None
 0.93A 3ko0B-4xdqA:
undetectable
3ko0J-4xdqA:
undetectable		 3ko0B-4xdqA:
14.87
3ko0J-4xdqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 GLY A 192
PHE A 147
PHE A 195
PHE A 206
 None
 0.88A 3ko0D-4xdqA:
undetectable
3ko0E-4xdqA:
undetectable		 3ko0D-4xdqA:
14.87
3ko0E-4xdqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 PHE A 195
PHE A 206
GLY A 192
PHE A 147
 None
 0.90A 3ko0B-4xdqA:
undetectable
3ko0J-4xdqA:
undetectable		 3ko0B-4xdqA:
14.87
3ko0J-4xdqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 GLY A 192
PHE A 147
PHE A 195
PHE A 206
 None
 0.89A 3ko0L-4xdqA:
undetectable
3ko0N-4xdqA:
undetectable		 3ko0L-4xdqA:
14.87
3ko0N-4xdqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 GLY A 192
PHE A 147
PHE A 195
PHE A 206
 None
 0.85A 3ko0M-4xdqA:
undetectable
3ko0P-4xdqA:
undetectable		 3ko0M-4xdqA:
14.87
3ko0P-4xdqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 GLY A 192
PHE A 147
PHE A 195
PHE A 206
 None
 0.86A 3ko0O-4xdqA:
undetectable
3ko0Q-4xdqA:
undetectable		 3ko0O-4xdqA:
14.87
3ko0Q-4xdqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 PHE A 195
PHE A 206
GLY A 192
PHE A 147
 None
 0.88A 3ko0K-4xdqA:
undetectable
3ko0S-4xdqA:
undetectable		 3ko0K-4xdqA:
14.87
3ko0S-4xdqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 PHE A 195
PHE A 206
GLY A 192
PHE A 147
 None
 0.99A 3ko0R-4xdqA:
undetectable
3ko0T-4xdqA:
undetectable		 3ko0R-4xdqA:
14.87
3ko0T-4xdqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TRP A 128
GLU A 148
VAL A 177
TRP A 149
 EDO  A 307 (-4.0A)
EDO  A 307 (-3.4A)
None
EDO  A 308 (-3.6A)
 1.10A 4uchA-4xdqA:
undetectable
4uchB-4xdqA:
undetectable		 4uchA-4xdqA:
19.01
4uchB-4xdqA:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 ARG A 117
ASP A 254
TRP A 255
 BEZ  A 306 (-3.5A)
CD  A 302 ( 2.3A)
BEZ  A 306 (-4.2A)
 0.00A 4xdqA-4xdqA:
45.5		 4xdqA-4xdqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 ASP A 254
GLY A  79
ASP A  76
 CD  A 302 ( 2.3A)
CA  A 301 (-3.8A)
None
 0.62A 4xdtA-4xdqA:
undetectable		 4xdtA-4xdqA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 5 ARG A  48
PRO A  60
ILE A  51
ASP A  58
 None
 1.49A 4z4hA-4xdqA:
undetectable		 4z4hA-4xdqA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 VAL A 177
TRP A 149
TRP A 128
GLU A 148
 None
EDO  A 308 (-3.6A)
EDO  A 307 (-4.0A)
EDO  A 307 (-3.4A)
 1.10A 6auuA-4xdqA:
undetectable
6auuB-4xdqA:
undetectable		 6auuA-4xdqA:
12.45
6auuB-4xdqA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 167
SER A 213
VAL A 209
VAL A 161
ASP A 145
 None
None
None
None
EDO  A 307 ( 4.3A)
 1.18A 6bxlB-4xdqA:
undetectable		 6bxlB-4xdqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0G_E_Y70E502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		 4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 PRO A 129
GLU A 148
SER A 157
TRP A 149
GLY A 238
 None
EDO  A 307 (-3.4A)
EDO  A 308 (-3.4A)
EDO  A 308 (-3.6A)
None
 1.46A 6h0gE-4xdqA:
0.0
6h0gF-4xdqA:
undetectable		 6h0gE-4xdqA:
16.35
6h0gF-4xdqA:
7.50