SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xdy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4xdy KETOL-ACID
REDUCTOISOMERASE
(uncultured
archaeon
GZfos26G2) 		5 / 12 GLY A 150
ASP A  11
GLY A  39
ARG A 142
ILE A  40
 None
None
None
GOL  A 405 (-3.9A)
None
 1.04A 1q8jB-4xdyA:
undetectable		 1q8jB-4xdyA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4xdy KETOL-ACID
REDUCTOISOMERASE
(uncultured
archaeon
GZfos26G2) 		5 / 10 ASP A  72
GLY A  45
PRO A  86
VAL A  89
ILE A  93
 None
None
NAI  A 403 (-3.6A)
NAI  A 403 (-4.8A)
None
 0.79A 3em4V-4xdyA:
undetectable		 3em4V-4xdyA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 4xdy KETOL-ACID
REDUCTOISOMERASE
(uncultured
archaeon
GZfos26G2) 		3 / 3 ARG A 120
ILE A  83
THR A  47
 None
None
NAI  A 403 ( 4.5A)
 0.64A 3ia4D-4xdyA:
undetectable		 3ia4D-4xdyA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4xdy KETOL-ACID
REDUCTOISOMERASE
(uncultured
archaeon
GZfos26G2) 		4 / 6 ILE A  83
ASN A 115
PRO A 123
LEU A 108
 None
 1.17A 3oi8A-4xdyA:
undetectable		 3oi8A-4xdyA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4xdy KETOL-ACID
REDUCTOISOMERASE
(uncultured
archaeon
GZfos26G2) 		3 / 3 TYR A  24
ASP A  37
ASP A  64
 None
None
GOL  A 405 (-3.7A)
 0.76A 3r24A-4xdyA:
2.7		 3r24A-4xdyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4xdy KETOL-ACID
REDUCTOISOMERASE
(uncultured
archaeon
GZfos26G2) 		5 / 10 PHE A 188
VAL A 157
ALA A 169
THR A 173
ILE A 183
 None
 1.37A 3t3qC-4xdyA:
undetectable		 3t3qC-4xdyA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4xdy KETOL-ACID
REDUCTOISOMERASE
(uncultured
archaeon
GZfos26G2) 		3 / 3 ASP A 128
GLU A 164
GLY A 163
 None
 0.53A 3w9tA-4xdyA:
undetectable		 3w9tA-4xdyA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4xdy KETOL-ACID
REDUCTOISOMERASE
(uncultured
archaeon
GZfos26G2) 		4 / 7 LEU A 102
PRO A 124
GLU A  95
TYR A  94
 None
 0.99A 4z4fA-4xdyA:
undetectable		 4z4fA-4xdyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4xdy KETOL-ACID
REDUCTOISOMERASE
(uncultured
archaeon
GZfos26G2) 		4 / 6 LEU A 102
PRO A 124
GLU A  95
TYR A  94
 None
 0.98A 4z4gA-4xdyA:
undetectable		 4z4gA-4xdyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4xdy KETOL-ACID
REDUCTOISOMERASE
(uncultured
archaeon
GZfos26G2) 		5 / 7 GLY A 113
GLU A 191
ALA A 133
PHE A 188
ASN A 115
 None
 1.40A 5mvsA-4xdyA:
3.7		 5mvsA-4xdyA:
22.90