SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xe3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		4 / 7 GLU A 365
LEU A 361
LEU A 161
GLY A 162
 HEM  A 501 ( 4.8A)
None
None
None
 0.90A 1mt1H-4xe3A:
undetectable
1mt1K-4xe3A:
undetectable		 1mt1H-4xe3A:
14.80
1mt1K-4xe3A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		4 / 7 VAL A 257
LEU A 131
ALA A 369
LEU A 373
 None
 0.80A 1pthA-4xe3A:
undetectable		 1pthA-4xe3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		4 / 7 VAL A 257
LEU A 131
ALA A 369
LEU A 373
 None
 0.80A 1pthB-4xe3A:
undetectable		 1pthB-4xe3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		5 / 12 LEU A 306
VAL A  64
VAL A  40
VAL A 299
ALA A 300
 None
 1.14A 1q23H-4xe3A:
undetectable
1q23I-4xe3A:
undetectable		 1q23H-4xe3A:
19.01
1q23I-4xe3A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		4 / 5 TYR A  17
PRO A 316
THR A  56
SER A  41
 None
 1.40A 1ymxA-4xe3A:
undetectable		 1ymxA-4xe3A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		4 / 5 LEU A 160
LEU A 161
LEU A 242
LEU A 241
 None
None
None
HEM  A 501 (-4.2A)
 1.02A 2ab2B-4xe3A:
2.5		 2ab2B-4xe3A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		3 / 3 ALA A 244
THR A 248
CYH A 356
 HEM  A 501 ( 3.5A)
CL6  A 502 (-3.6A)
HEM  A 501 (-2.2A)
 0.59A 3e4eA-4xe3A:
27.4		 3e4eA-4xe3A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		3 / 3 ALA A 244
THR A 248
CYH A 356
 HEM  A 501 ( 3.5A)
CL6  A 502 (-3.6A)
HEM  A 501 (-2.2A)
 0.49A 3e4eB-4xe3A:
23.6		 3e4eB-4xe3A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		3 / 3 PRO A 289
SER A 292
ASN A 255
 None
 0.86A 3lslG-4xe3A:
undetectable		 3lslG-4xe3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		4 / 7 GLU A 329
ASP A 327
ARG A  57
THR A  56
 None
 1.28A 3mbgA-4xe3A:
undetectable
3mbgB-4xe3A:
undetectable		 3mbgA-4xe3A:
17.13
3mbgB-4xe3A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		5 / 12 PRO A 151
LEU A 131
LEU A 373
ILE A 253
TYR A 267
 None
 1.37A 4a79A-4xe3A:
undetectable		 4a79A-4xe3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		5 / 12 PRO A 151
LEU A 131
LEU A 373
ILE A 253
TYR A 267
 None
 1.33A 4a79B-4xe3A:
undetectable		 4a79B-4xe3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		3 / 3 GLU A 283
ASP A 338
ASP A 335
 None
 0.79A 4gc9A-4xe3A:
undetectable		 4gc9A-4xe3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		4 / 6 ARG A 172
ALA A 155
ASP A 169
LEU A 127
 None
 1.07A 4ot2A-4xe3A:
undetectable		 4ot2A-4xe3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4xe3 CYTOCHROME P-450
(Streptomyces
antibioticus) 		5 / 12 ASP A 143
SER A 175
LEU A 361
ALA A 244
ILE A 397
 None
None
None
HEM  A 501 ( 3.5A)
CL6  A 502 (-4.8A)
 1.21A 5vc0A-4xe3A:
27.0		 5vc0A-4xe3A:
24.54