SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 GLU A 142
HIS A  71
HIS A  67
GLU A  70
 NI  A 502 (-3.1A)
NI  A 502 (-3.4A)
NI  A 502 (-3.4A)
NI  A 502 ( 4.6A)
 0.91A 1v7zA-4xeaA:
undetectable		 1v7zA-4xeaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 GLU A 142
HIS A  71
HIS A  67
GLU A  70
 NI  A 502 (-3.1A)
NI  A 502 (-3.4A)
NI  A 502 (-3.4A)
NI  A 502 ( 4.6A)
 0.93A 1v7zB-4xeaA:
undetectable		 1v7zB-4xeaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 GLU A 142
HIS A  71
HIS A  67
GLU A  70
 NI  A 502 (-3.1A)
NI  A 502 (-3.4A)
NI  A 502 (-3.4A)
NI  A 502 ( 4.6A)
 0.92A 1v7zC-4xeaA:
undetectable		 1v7zC-4xeaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 ALA A  94
HIS A  71
GLU A  70
HIS A  67
GLU A 142
 None
NI  A 502 (-3.4A)
NI  A 502 ( 4.6A)
NI  A 502 (-3.4A)
NI  A 502 (-3.1A)
 0.80A 2c6nA-4xeaA:
undetectable		 2c6nA-4xeaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 TYR A 383
PHE A 393
ILE A 397
VAL A 366
ALA A 280
 None
 1.20A 2g72B-4xeaA:
undetectable		 2g72B-4xeaA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 HIS A 341
ALA A 311
VAL A 324
LEU A 416
 ACT  A 504 (-4.7A)
None
None
None
 0.89A 2it4A-4xeaA:
undetectable		 2it4A-4xeaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 ILE A 213
PHE A 105
GLY A 207
GLY A 206
 None
 0.87A 2qx4A-4xeaA:
undetectable
2qx4B-4xeaA:
undetectable		 2qx4A-4xeaA:
20.32
2qx4B-4xeaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A 153
GLU A 157
SER A  47
 None
 0.83A 2xctD-4xeaA:
undetectable		 2xctD-4xeaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A 153
GLU A 157
SER A 178
 None
 0.91A 2xctD-4xeaA:
undetectable		 2xctD-4xeaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 GLU A 142
HIS A  71
HIS A  67
GLU A  70
 NI  A 502 (-3.1A)
NI  A 502 (-3.4A)
NI  A 502 (-3.4A)
NI  A 502 ( 4.6A)
 0.91A 3a6jA-4xeaA:
undetectable		 3a6jA-4xeaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 7 GLU A 142
HIS A  71
HIS A  67
GLU A  70
 NI  A 502 (-3.1A)
NI  A 502 (-3.4A)
NI  A 502 (-3.4A)
NI  A 502 ( 4.6A)
 0.88A 3a6jB-4xeaA:
undetectable		 3a6jB-4xeaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 GLU A 142
HIS A  71
HIS A  67
GLU A  70
 NI  A 502 (-3.1A)
NI  A 502 (-3.4A)
NI  A 502 (-3.4A)
NI  A 502 ( 4.6A)
 0.88A 3a6jC-4xeaA:
undetectable		 3a6jC-4xeaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 GLU A 142
HIS A  71
HIS A  67
GLU A  70
 NI  A 502 (-3.1A)
NI  A 502 (-3.4A)
NI  A 502 (-3.4A)
NI  A 502 ( 4.6A)
 0.90A 3a6jE-4xeaA:
undetectable		 3a6jE-4xeaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 GLU A 142
HIS A  71
HIS A  67
GLU A  70
 NI  A 502 (-3.1A)
NI  A 502 (-3.4A)
NI  A 502 (-3.4A)
NI  A 502 ( 4.6A)
 0.88A 3a6jF-4xeaA:
undetectable		 3a6jF-4xeaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 LEU A 323
GLY A 262
LEU A 259
LEU A 158
LEU A 159
 None
 1.28A 3cjtK-4xeaA:
undetectable		 3cjtK-4xeaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 7 LEU A 334
ARG A 258
SER A 293
GLY A 308
 None
 1.08A 3hcrB-4xeaA:
undetectable		 3hcrB-4xeaA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 11 ALA A 408
ARG A 407
ILE A 350
LEU A 284
LEU A 416
 None
None
ACT  A 504 ( 4.7A)
None
None
 1.10A 3kw2A-4xeaA:
undetectable		 3kw2A-4xeaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 11 ALA A 408
ARG A 407
ILE A 350
LEU A 284
LEU A 416
 None
None
ACT  A 504 ( 4.7A)
None
None
 1.12A 3kw2B-4xeaA:
undetectable		 3kw2B-4xeaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 5 TYR A  38
THR A  37
ARG A  31
LEU A 376
 None
 1.20A 3qelC-4xeaA:
undetectable		 3qelC-4xeaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 7 GLY A 262
ILE A 338
LEU A 342
PHE A 289
 None
 0.85A 4ejjD-4xeaA:
undetectable		 4ejjD-4xeaA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 GLU A 265
ARG A 407
LEU A 284
ILE A 283
LEU A 400
 None
 1.42A 4k36B-4xeaA:
undetectable		 4k36B-4xeaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 GLU A 265
ARG A 407
LEU A 284
ILE A 283
LEU A 400
 None
 1.47A 4k38A-4xeaA:
undetectable
4k38D-4xeaA:
undetectable		 4k38A-4xeaA:
22.39
4k38D-4xeaA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 GLU A 265
ARG A 407
LEU A 284
ILE A 283
LEU A 400
 None
 1.47A 4k38B-4xeaA:
undetectable		 4k38B-4xeaA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 7 GLU A 414
GLU A 265
TYR A 313
LEU A 285
 None
 1.15A 4twdF-4xeaA:
undetectable
4twdJ-4xeaA:
undetectable		 4twdF-4xeaA:
21.43
4twdJ-4xeaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 6 ALA A  42
THR A  43
TYR A 195
HIS A 100
 None
 1.00A 5eclA-4xeaA:
undetectable		 5eclA-4xeaA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 5 ALA A  42
THR A  43
TYR A 195
HIS A 100
 None
 1.14A 5ecmA-4xeaA:
undetectable		 5ecmA-4xeaA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 4 SER A 310
ALA A 311
GLN A 314
THR A 322
 None
 1.38A 5n0rA-4xeaA:
undetectable		 5n0rA-4xeaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 4 SER A 310
ALA A 311
GLN A 314
THR A 322
 None
 1.39A 5n0sA-4xeaA:
undetectable		 5n0sA-4xeaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 5 SER A 310
ALA A 311
GLN A 314
THR A 322
 None
 1.41A 5n0tA-4xeaA:
undetectable		 5n0tA-4xeaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 4 SER A 310
ALA A 311
GLN A 314
THR A 322
 None
 1.37A 5n0wA-4xeaA:
undetectable		 5n0wA-4xeaA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 5 SER A 310
ALA A 311
GLN A 314
THR A 322
 None
 1.35A 5n0wB-4xeaA:
undetectable		 5n0wB-4xeaA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 4 SER A 310
ALA A 311
GLN A 314
THR A 322
 None
 1.37A 5n0xA-4xeaA:
undetectable		 5n0xA-4xeaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 5 SER A 310
ALA A 311
GLN A 314
THR A 322
 None
 1.35A 5n4iA-4xeaA:
undetectable		 5n4iA-4xeaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 SER A 124
ILE A 125
LEU A  20
PHE A  41
LEU A 202
 None
 1.38A 6a93A-4xeaA:
undetectable		 6a93A-4xeaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 4xea PEPTIDASE M16 DOMAIN
PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 11 GLU A 135
PHE A  74
ALA A  94
THR A 101
THR A  43
 None
 1.29A 6efnA-4xeaA:
undetectable		 6efnA-4xeaA:
23.49