SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xeb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		12 / 12 ALA A 140
TYR A 142
TYR A 168
ASP A 170
SER A 171
GLN A 172
GLU A 209
ASP A 211
GLU A 214
THR A 243
ARG A 248
ASP A 373
 CE6  A 505 ( 4.7A)
CE6  A 505 (-4.3A)
None
K  A 506 (-3.2A)
K  A 506 ( 4.8A)
CBI  A 504 (-4.4A)
K  A 506 (-2.6A)
K  A 506 ( 4.7A)
CBI  A 504 ( 4.4A)
CBI  A 504 (-3.1A)
CBI  A 504 (-2.8A)
None
 0.30A 1dy4A-4xebA:
64.9		 1dy4A-4xebA:
64.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		3 / 3 THR A 384
PRO A 386
THR A 387
 None
 0.88A 1ovfB-4xebA:
undetectable		 1ovfB-4xebA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		3 / 3 HIS A 132
ASP A 278
ASN A 310
 None
 0.64A 1wg8B-4xebA:
undetectable		 1wg8B-4xebA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		4 / 8 TYR A 155
PHE A 179
ASN A 158
GLY A 151
 None
PCA  A   1 ( 3.7A)
PCA  A   1 ( 3.7A)
None
 1.06A 1ykiC-4xebA:
undetectable
1ykiD-4xebA:
undetectable		 1ykiC-4xebA:
18.18
1ykiD-4xebA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		4 / 6 TYR A 164
ASP A  74
THR A  10
GLU A   9
 None
 1.46A 2dttB-4xebA:
undetectable
2dttC-4xebA:
undetectable		 2dttB-4xebA:
14.02
2dttC-4xebA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		3 / 3 GLY A 165
ARG A  39
TYR A 106
 None
 0.78A 2opxA-4xebA:
undetectable		 2opxA-4xebA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		5 / 12 ILE A 180
GLY A 150
GLY A 167
ALA A 205
VAL A 152
 None
 1.10A 2yvlB-4xebA:
undetectable		 2yvlB-4xebA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		4 / 6 SER A 369
ASP A 211
TYR A 142
PRO A 174
 CE6  A 505 (-2.7A)
K  A 506 ( 4.7A)
CE6  A 505 (-4.3A)
None
 1.48A 3jqaA-4xebA:
undetectable		 3jqaA-4xebA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		4 / 6 SER A 369
ASP A 211
TYR A 142
PRO A 174
 CE6  A 505 (-2.7A)
K  A 506 ( 4.7A)
CE6  A 505 (-4.3A)
None
 1.46A 3jqaB-4xebA:
undetectable		 3jqaB-4xebA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		4 / 6 SER A 369
ASP A 211
TYR A 142
PRO A 174
 CE6  A 505 (-2.7A)
K  A 506 ( 4.7A)
CE6  A 505 (-4.3A)
None
 1.46A 3jqaD-4xebA:
undetectable		 3jqaD-4xebA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		3 / 3 TYR A 155
GLY A 151
ASP A 149
 None
 0.60A 3ou6C-4xebA:
undetectable		 3ou6C-4xebA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		4 / 8 ASP A 211
GLY A 257
GLU A 214
ARG A 248
 K  A 506 ( 4.7A)
None
CBI  A 504 ( 4.4A)
CBI  A 504 (-2.8A)
 0.94A 3s3nA-4xebA:
undetectable		 3s3nA-4xebA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		4 / 7 TYR A 142
THR A 105
TYR A 168
TYR A 106
 CE6  A 505 (-4.3A)
None
None
None
 1.49A 3wipF-4xebA:
undetectable
3wipG-4xebA:
undetectable		 3wipF-4xebA:
18.69
3wipG-4xebA:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		9 / 9 ASN A 138
ALA A 140
TYR A 142
TYR A 168
ASP A 170
GLU A 209
ASP A 211
GLU A 214
TRP A 371
 None
CE6  A 505 ( 4.7A)
CE6  A 505 (-4.3A)
None
K  A 506 (-3.2A)
K  A 506 (-2.6A)
K  A 506 ( 4.7A)
CBI  A 504 ( 4.4A)
CE6  A 505 (-3.7A)
 0.49A 4ipmA-4xebA:
62.3		 4ipmA-4xebA:
52.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		4 / 5 TYR A 168
THR A 420
THR A  33
MET A 108
 None
 1.32A 4mbsB-4xebA:
undetectable		 4mbsB-4xebA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		4 / 5 TYR A 168
SER A 369
ASP A 211
ASP A 259
 None
CE6  A 505 (-2.7A)
K  A 506 ( 4.7A)
CL  A 510 (-3.4A)
 1.10A 4qtuB-4xebA:
undetectable		 4qtuB-4xebA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		3 / 3 GLU A 187
THR A 236
HIS A 203
 None
 0.80A 4ydqB-4xebA:
undetectable		 4ydqB-4xebA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		5 / 12 LEU A 353
GLY A 352
PHE A 260
GLU A 337
TYR A 333
 None
None
None
CL  A 510 ( 4.6A)
None
 1.22A 5czyA-4xebA:
undetectable		 5czyA-4xebA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		3 / 3 SER A 331
LEU A 210
MET A 356
 None
 0.80A 5ikrB-4xebA:
undetectable		 5ikrB-4xebA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		5 / 11 GLN A 183
ASP A 147
TYR A 168
PRO A 174
LEU A 177
 None
 1.29A 5jh7D-4xebA:
undetectable		 5jh7D-4xebA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		3 / 3 THR A 344
SER A 346
ASP A 259
 NA  A 509 (-3.4A)
None
CL  A 510 (-3.4A)
 0.57A 5kvaA-4xebA:
undetectable		 5kvaA-4xebA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		3 / 3 THR A 344
SER A 346
ASP A 259
 NA  A 509 (-3.4A)
None
CL  A 510 (-3.4A)
 0.58A 5kvaB-4xebA:
undetectable		 5kvaB-4xebA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		5 / 9 ILE A  84
LEU A 370
GLY A 102
ASN A 100
ALA A 140
 None
None
None
CE6  A 505 (-3.6A)
CE6  A 505 ( 4.7A)
 1.37A 5x66C-4xebA:
undetectable		 5x66C-4xebA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4xeb GLUCANASE
(Talaromyces
funiculosus) 		5 / 10 GLY A 241
GLY A 251
ALA A 239
THR A 237
GLY A 204
 None
 1.11A 6e5zA-4xebA:
undetectable		 6e5zA-4xebA:
16.67