SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xee'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		4 / 7 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.88A 1gtiA-4xeeA:
undetectable		 1gtiA-4xeeA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		3 / 3 ARG A 299
ASP A1010
ASN A1144
 None
 0.96A 1nbhA-4xeeA:
undetectable		 1nbhA-4xeeA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		3 / 3 ARG A 299
ASP A1010
ASN A1144
 None
 0.95A 1nbhD-4xeeA:
undetectable		 1nbhD-4xeeA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 12 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 0.93A 2aclA-4xeeA:
undetectable
2aclE-4xeeA:
undetectable		 2aclA-4xeeA:
18.46
2aclE-4xeeA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 10 TYR A 324
ARG A 328
TYR A 359
THR A 354
TYR A 146
 None
 1.41A 2coiA-4xeeA:
undetectable
2coiB-4xeeA:
undetectable		 2coiA-4xeeA:
22.10
2coiB-4xeeA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 10 TYR A 146
TYR A 324
ARG A 328
TYR A 359
THR A 354
 None
 1.41A 2coiA-4xeeA:
undetectable
2coiB-4xeeA:
undetectable		 2coiA-4xeeA:
22.10
2coiB-4xeeA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		4 / 6 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.04A 2e1qA-4xeeA:
undetectable		 2e1qA-4xeeA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		4 / 6 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.04A 2e1qC-4xeeA:
0.2		 2e1qC-4xeeA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		4 / 5 ARG A1096
MET A 267
THR A 265
LEU A 264
 None
 1.38A 2eimJ-4xeeA:
undetectable		 2eimJ-4xeeA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		4 / 5 ARG A1096
MET A 267
THR A 265
LEU A 264
 None
 1.43A 2eimW-4xeeA:
undetectable		 2eimW-4xeeA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		4 / 8 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.03A 2xytE-4xeeA:
undetectable		 2xytE-4xeeA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		4 / 8 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 0.98A 2xytH-4xeeA:
undetectable		 2xytH-4xeeA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		4 / 7 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.00A 2xytI-4xeeA:
undetectable		 2xytI-4xeeA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		4 / 6 ARG A 327
ARG A 328
ILE A 238
TYR A 347
 None
 1.19A 2yfbB-4xeeA:
5.2		 2yfbB-4xeeA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		4 / 5 ARG A1096
MET A 267
THR A 265
LEU A 264
 None
 1.32A 3ag1J-4xeeA:
undetectable		 3ag1J-4xeeA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		4 / 5 ARG A1096
MET A 267
THR A 265
LEU A 264
 None
 1.33A 3ag4J-4xeeA:
undetectable		 3ag4J-4xeeA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 10 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 1.02A 3falC-4xeeA:
undetectable		 3falC-4xeeA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 11 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 0.95A 3fc6A-4xeeA:
undetectable		 3fc6A-4xeeA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		5 / 12 ASN A  82
GLY A  81
ASP A 113
ASN A 370
PHE A 376
 None
 1.26A 3k13C-4xeeA:
undetectable		 3k13C-4xeeA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		4 / 6 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.23A 3peoG-4xeeA:
undetectable		 3peoG-4xeeA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_B_VIBB501_1
(THIAMINE
PYRIDINYLASE I)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 11 TYR A 154
ASP A 150
ILE A 238
TYR A 324
LEU A 329
 None
 1.39A 4kysB-4xeeA:
undetectable		 4kysB-4xeeA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 12 ASP A 216
SER A  53
GLY A 217
GLY A  50
ASP A  54
 None
None
None
None
PEG  A1205 ( 4.5A)
 1.36A 4pevB-4xeeA:
undetectable		 4pevB-4xeeA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 9 ALA A 157
ALA A 155
SER A 112
SER A 108
ALA A 161
 None
 1.14A 4twdA-4xeeA:
3.1
4twdB-4xeeA:
2.8
4twdC-4xeeA:
3.0
4twdD-4xeeA:
2.9
4twdE-4xeeA:
3.0		 4twdA-4xeeA:
18.39
4twdB-4xeeA:
18.39
4twdC-4xeeA:
18.39
4twdD-4xeeA:
18.39
4twdE-4xeeA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 9 ALA A 161
ALA A 157
ALA A 155
SER A 112
SER A 108
 None
 1.04A 4twdA-4xeeA:
3.1
4twdB-4xeeA:
2.8
4twdC-4xeeA:
3.0
4twdD-4xeeA:
2.9
4twdE-4xeeA:
3.0		 4twdA-4xeeA:
18.39
4twdB-4xeeA:
18.39
4twdC-4xeeA:
18.39
4twdD-4xeeA:
18.39
4twdE-4xeeA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		4 / 7 THR A1026
TYR A1018
GLU A1011
HIS A1031
 None
None
EPE  A1203 ( 4.3A)
None
 1.06A 5ecnA-4xeeA:
undetectable		 5ecnA-4xeeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		3 / 3 THR A 265
ALA A1093
ASN A1002
 None
 0.55A 5ersA-4xeeA:
undetectable		 5ersA-4xeeA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		3 / 3 ARG A 328
THR A 153
ASP A 150
 None
 0.89A 5g5gA-4xeeA:
undetectable
5g5gB-4xeeA:
undetectable		 5g5gA-4xeeA:
18.08
5g5gB-4xeeA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		4 / 8 SER A 245
PHE A 358
ASN A 241
SER A 361
 None
 1.07A 5l1fA-4xeeA:
1.9
5l1fB-4xeeA:
undetectable		 5l1fA-4xeeA:
19.43
5l1fB-4xeeA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		4 / 5 ARG A1096
MET A 267
THR A 265
LEU A 264
 None
 1.28A 5wauJ-4xeeA:
undetectable		 5wauJ-4xeeA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		4 / 5 ARG A1096
MET A 267
THR A 265
LEU A 264
 None
 1.24A 5x19J-4xeeA:
undetectable		 5x19J-4xeeA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		5 / 12 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 0.98A 6a5zL-4xeeA:
undetectable		 6a5zL-4xeeA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		4 / 5 ARG A1096
MET A 267
THR A 265
LEU A 264
 None
 1.37A 6nknJ-4xeeA:
undetectable		 6nknJ-4xeeA:
8.11