SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4xef PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		4 / 8 LEU A 931
VAL A 994
THR A 942
ASP A 925
 None
 1.15A 1o76B-4xefA:
undetectable		 1o76B-4xefA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4xef PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		4 / 6 THR A 978
ASP A 986
ASN A 989
ASP A 992
 None
 1.32A 2okcA-4xefA:
undetectable		 2okcA-4xefA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4xef PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		4 / 6 LEU A 887
THR A 916
LEU A 950
ASP A 986
 None
 1.09A 2wm3A-4xefA:
undetectable		 2wm3A-4xefA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 4xef PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		5 / 10 LEU A 920
LEU A 917
SER A 980
LEU A 983
LEU A 887
 None
 1.07A 2xn7A-4xefA:
undetectable
2xn7B-4xefA:
undetectable		 2xn7A-4xefA:
19.83
2xn7B-4xefA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4xef PROTEIN-TYROSINE
KINASE 2-BETA
20-MER PEPTIDE
CONTAINING LD1 MOTIF
OF LEUPAXIN
(Homo
sapiens;
Homo
sapiens) 		5 / 11 LEU A 953
HIS A 981
LEU A 983
ALA A 979
LEU B  11
 None
 1.07A 4p65C-4xefA:
undetectable
4p65D-4xefA:
undetectable
4p65J-4xefA:
undetectable
4p65L-4xefA:
undetectable		 4p65C-4xefA:
6.47
4p65D-4xefA:
8.63
4p65J-4xefA:
8.63
4p65L-4xefA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4xef PROTEIN-TYROSINE
KINASE 2-BETA
20-MER PEPTIDE
CONTAINING LD1 MOTIF
OF LEUPAXIN
(Homo
sapiens;
Homo
sapiens) 		5 / 11 LEU A 953
HIS A 981
LEU A 983
ALA A 979
LEU B  11
 None
 1.06A 4p65E-4xefA:
undetectable
4p65F-4xefA:
undetectable
4p65J-4xefA:
undetectable
4p65L-4xefA:
undetectable		 4p65E-4xefA:
6.47
4p65F-4xefA:
8.63
4p65J-4xefA:
8.63
4p65L-4xefA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4xef PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens) 		3 / 3 MET A 976
GLN A 975
ARG A 974
 None
 1.09A 5ewzB-4xefA:
3.6		 5ewzB-4xefA:
21.83