SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xeh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.25A 1c9sA-4xehA:
undetectable
1c9sK-4xehA:
undetectable
1c9sA-4xehA:
14.06
1c9sK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.25A 1c9sB-4xehA:
undetectable
1c9sC-4xehA:
undetectable
1c9sB-4xehA:
14.06
1c9sC-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.25A 1c9sC-4xehA:
undetectable
1c9sD-4xehA:
undetectable
1c9sC-4xehA:
14.06
1c9sD-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 1c9sD-4xehA:
undetectable
1c9sE-4xehA:
undetectable
1c9sD-4xehA:
14.06
1c9sE-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.24A 1c9sE-4xehA:
undetectable
1c9sF-4xehA:
undetectable
1c9sE-4xehA:
14.06
1c9sF-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.26A 1c9sF-4xehA:
undetectable
1c9sG-4xehA:
undetectable
1c9sF-4xehA:
14.06
1c9sG-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 1c9sG-4xehA:
undetectable
1c9sH-4xehA:
undetectable
1c9sG-4xehA:
14.06
1c9sH-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.26A 1c9sH-4xehA:
undetectable
1c9sI-4xehA:
undetectable
1c9sH-4xehA:
14.06
1c9sI-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.23A 1c9sJ-4xehA:
undetectable
1c9sK-4xehA:
undetectable
1c9sJ-4xehA:
14.06
1c9sK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.27A 1c9sO-4xehA:
undetectable
1c9sP-4xehA:
undetectable
1c9sO-4xehA:
14.06
1c9sP-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
4 / 8 MET A  84
ALA A 288
PHE A 114
ILE A 292
None
1.17A 1gm7A-4xehA:
undetectable
1gm7B-4xehA:
undetectable
1gm7A-4xehA:
21.01
1gm7B-4xehA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 1gtfA-4xehA:
undetectable
1gtfK-4xehA:
undetectable
1gtfA-4xehA:
14.06
1gtfK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.27A 1gtfB-4xehA:
undetectable
1gtfC-4xehA:
undetectable
1gtfB-4xehA:
14.06
1gtfC-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.26A 1gtfC-4xehA:
undetectable
1gtfD-4xehA:
undetectable
1gtfC-4xehA:
14.06
1gtfD-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 1gtfE-4xehA:
undetectable
1gtfF-4xehA:
undetectable
1gtfE-4xehA:
14.06
1gtfF-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 1gtfG-4xehA:
undetectable
1gtfH-4xehA:
undetectable
1gtfG-4xehA:
14.06
1gtfH-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.29A 1gtfH-4xehA:
undetectable
1gtfI-4xehA:
undetectable
1gtfH-4xehA:
14.06
1gtfI-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.26A 1gtfI-4xehA:
undetectable
1gtfJ-4xehA:
undetectable
1gtfI-4xehA:
14.06
1gtfJ-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.34A 1gtfP-4xehA:
undetectable
1gtfQ-4xehA:
undetectable
1gtfP-4xehA:
14.06
1gtfQ-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 11 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.33A 1gtfU-4xehA:
undetectable
1gtfV-4xehA:
undetectable
1gtfU-4xehA:
14.06
1gtfV-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.31A 1gtnN-4xehA:
undetectable
1gtnO-4xehA:
undetectable
1gtnN-4xehA:
14.06
1gtnO-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 1utdC-4xehA:
undetectable
1utdD-4xehA:
undetectable
1utdC-4xehA:
14.06
1utdD-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.24A 1utdD-4xehA:
undetectable
1utdE-4xehA:
undetectable
1utdD-4xehA:
14.06
1utdE-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.25A 1utdG-4xehA:
undetectable
1utdH-4xehA:
undetectable
1utdG-4xehA:
14.06
1utdH-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.29A 1utdN-4xehA:
undetectable
1utdO-4xehA:
undetectable
1utdN-4xehA:
14.06
1utdO-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.34A 1utdR-4xehA:
undetectable
1utdS-4xehA:
undetectable
1utdR-4xehA:
14.06
1utdS-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 12 TYR A 141
LEU A  12
ILE A  20
ILE A  22
ILE A 172
None
1.16A 2efjA-4xehA:
3.1
2efjA-4xehA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
4 / 7 GLU A  13
LYS A 170
PRO A  14
ALA A 167
None
1.32A 2ejgA-4xehA:
undetectable
2ejgA-4xehA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
4 / 7 GLU A  13
LYS A 170
PRO A  14
ALA A 167
None
1.38A 2ejgB-4xehA:
undetectable
2ejgB-4xehA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 11 SER A 132
ILE A 172
GLY A 173
GLY A 146
SER A  27
None
0.99A 2qmmA-4xehA:
undetectable
2qmmB-4xehA:
undetectable
2qmmA-4xehA:
23.81
2qmmB-4xehA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 11 LEU A 166
ALA A 149
ILE A 172
VAL A 137
GLY A 146
None
0.86A 3ebzB-4xehA:
undetectable
3ebzB-4xehA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
4 / 8 ARG A  49
ALA A  57
ASP A  60
GLY A  29
None
0.78A 3el9A-4xehA:
undetectable
3el9A-4xehA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
4 / 7 ILE A 172
TYR A 126
VAL A 105
LEU A  41
None
0.82A 3elzA-4xehA:
undetectable
3elzA-4xehA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
4 / 5 GLY A 243
LYS A 242
GLU A 241
GLY A 246
None
0.87A 3onnA-4xehA:
2.1
3onnA-4xehA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
3 / 3 TYR A  25
ASP A  38
ASP A  60
None
0.61A 3r24A-4xehA:
2.7
3r24A-4xehA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
3 / 3 ASP A 124
GLU A 160
GLY A 159
None
0.36A 3w9tA-4xehA:
undetectable
3w9tA-4xehA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
4 / 8 ASN A  35
ALA A  31
TYR A  25
ARG A  30
None
1.14A 4ijiF-4xehA:
undetectable
4ijiF-4xehA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 ALA A 169
ALA A 165
VAL A 147
GLY A 178
ALA A 149
None
0.95A 4qvnK-4xehA:
undetectable
4qvnL-4xehA:
undetectable
4qvnK-4xehA:
21.47
4qvnL-4xehA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 ALA A 169
ALA A 165
VAL A 147
GLY A 178
ALA A 149
None
0.96A 4qvnY-4xehA:
undetectable
4qvnZ-4xehA:
undetectable
4qvnY-4xehA:
21.47
4qvnZ-4xehA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.25A 5eeuA-4xehA:
undetectable
5eeuB-4xehA:
undetectable
5eeuA-4xehA:
14.06
5eeuB-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.27A 5eeuB-4xehA:
undetectable
5eeuC-4xehA:
undetectable
5eeuB-4xehA:
14.06
5eeuC-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.27A 5eeuD-4xehA:
undetectable
5eeuE-4xehA:
undetectable
5eeuD-4xehA:
14.06
5eeuE-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.27A 5eeuE-4xehA:
undetectable
5eeuF-4xehA:
undetectable
5eeuE-4xehA:
14.06
5eeuF-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.31A 5eeuG-4xehA:
undetectable
5eeuH-4xehA:
undetectable
5eeuG-4xehA:
14.06
5eeuH-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.24A 5eeuH-4xehA:
undetectable
5eeuI-4xehA:
undetectable
5eeuH-4xehA:
14.06
5eeuI-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.24A 5eeuJ-4xehA:
undetectable
5eeuK-4xehA:
undetectable
5eeuJ-4xehA:
14.06
5eeuK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.27A 5eeuA-4xehA:
undetectable
5eeuK-4xehA:
undetectable
5eeuA-4xehA:
14.06
5eeuK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.33A 5eeuN-4xehA:
undetectable
5eeuO-4xehA:
undetectable
5eeuN-4xehA:
14.06
5eeuO-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.31A 5eeuP-4xehA:
undetectable
5eeuQ-4xehA:
undetectable
5eeuP-4xehA:
14.06
5eeuQ-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 5eeuR-4xehA:
undetectable
5eeuS-4xehA:
undetectable
5eeuR-4xehA:
14.06
5eeuS-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.31A 5eeuS-4xehA:
undetectable
5eeuT-4xehA:
undetectable
5eeuS-4xehA:
14.06
5eeuT-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.27A 5eevB-4xehA:
undetectable
5eevC-4xehA:
undetectable
5eevB-4xehA:
14.06
5eevC-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.27A 5eevD-4xehA:
undetectable
5eevE-4xehA:
undetectable
5eevD-4xehA:
14.06
5eevE-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.32A 5eevG-4xehA:
undetectable
5eevH-4xehA:
undetectable
5eevG-4xehA:
14.06
5eevH-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.25A 5eevH-4xehA:
undetectable
5eevI-4xehA:
undetectable
5eevH-4xehA:
14.06
5eevI-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.24A 5eevJ-4xehA:
undetectable
5eevK-4xehA:
undetectable
5eevJ-4xehA:
14.06
5eevK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 5eevA-4xehA:
undetectable
5eevK-4xehA:
undetectable
5eevA-4xehA:
14.06
5eevK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.33A 5eevN-4xehA:
undetectable
5eevO-4xehA:
undetectable
5eevN-4xehA:
14.06
5eevO-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.32A 5eevP-4xehA:
undetectable
5eevQ-4xehA:
undetectable
5eevP-4xehA:
14.06
5eevQ-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 5eevR-4xehA:
undetectable
5eevS-4xehA:
undetectable
5eevR-4xehA:
14.06
5eevS-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.32A 5eevS-4xehA:
undetectable
5eevT-4xehA:
undetectable
5eevS-4xehA:
14.06
5eevT-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 5eewB-4xehA:
undetectable
5eewC-4xehA:
undetectable
5eewB-4xehA:
14.06
5eewC-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.27A 5eewD-4xehA:
undetectable
5eewE-4xehA:
undetectable
5eewD-4xehA:
14.06
5eewE-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.32A 5eewG-4xehA:
undetectable
5eewH-4xehA:
undetectable
5eewG-4xehA:
14.06
5eewH-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.25A 5eewH-4xehA:
undetectable
5eewI-4xehA:
undetectable
5eewH-4xehA:
14.06
5eewI-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.24A 5eewJ-4xehA:
undetectable
5eewK-4xehA:
undetectable
5eewJ-4xehA:
14.06
5eewK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 5eewA-4xehA:
undetectable
5eewK-4xehA:
undetectable
5eewA-4xehA:
14.06
5eewK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.33A 5eewN-4xehA:
undetectable
5eewO-4xehA:
undetectable
5eewN-4xehA:
14.06
5eewO-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.32A 5eewP-4xehA:
undetectable
5eewQ-4xehA:
undetectable
5eewP-4xehA:
14.06
5eewQ-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.29A 5eewR-4xehA:
undetectable
5eewS-4xehA:
undetectable
5eewR-4xehA:
14.06
5eewS-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.32A 5eewS-4xehA:
undetectable
5eewT-4xehA:
undetectable
5eewS-4xehA:
14.06
5eewT-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 5eexB-4xehA:
undetectable
5eexC-4xehA:
undetectable
5eexB-4xehA:
14.06
5eexC-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.27A 5eexD-4xehA:
undetectable
5eexE-4xehA:
undetectable
5eexD-4xehA:
14.06
5eexE-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.32A 5eexG-4xehA:
undetectable
5eexH-4xehA:
undetectable
5eexG-4xehA:
14.06
5eexH-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.26A 5eexH-4xehA:
undetectable
5eexI-4xehA:
undetectable
5eexH-4xehA:
14.06
5eexI-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.24A 5eexJ-4xehA:
undetectable
5eexK-4xehA:
undetectable
5eexJ-4xehA:
14.06
5eexK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 5eexA-4xehA:
undetectable
5eexK-4xehA:
undetectable
5eexA-4xehA:
14.06
5eexK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.33A 5eexN-4xehA:
undetectable
5eexO-4xehA:
undetectable
5eexN-4xehA:
14.06
5eexO-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.32A 5eexP-4xehA:
undetectable
5eexQ-4xehA:
undetectable
5eexP-4xehA:
14.06
5eexQ-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.29A 5eexR-4xehA:
undetectable
5eexS-4xehA:
undetectable
5eexR-4xehA:
14.06
5eexS-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.32A 5eexS-4xehA:
undetectable
5eexT-4xehA:
undetectable
5eexS-4xehA:
14.06
5eexT-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 5eeyB-4xehA:
undetectable
5eeyC-4xehA:
undetectable
5eeyB-4xehA:
14.06
5eeyC-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.27A 5eeyD-4xehA:
undetectable
5eeyE-4xehA:
undetectable
5eeyD-4xehA:
14.06
5eeyE-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.33A 5eeyG-4xehA:
undetectable
5eeyH-4xehA:
undetectable
5eeyG-4xehA:
14.06
5eeyH-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.25A 5eeyH-4xehA:
undetectable
5eeyI-4xehA:
undetectable
5eeyH-4xehA:
14.06
5eeyI-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.24A 5eeyJ-4xehA:
undetectable
5eeyK-4xehA:
undetectable
5eeyJ-4xehA:
14.06
5eeyK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 5eeyA-4xehA:
undetectable
5eeyK-4xehA:
undetectable
5eeyA-4xehA:
14.06
5eeyK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.33A 5eeyN-4xehA:
undetectable
5eeyO-4xehA:
undetectable
5eeyN-4xehA:
14.06
5eeyO-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.32A 5eeyP-4xehA:
undetectable
5eeyQ-4xehA:
undetectable
5eeyP-4xehA:
14.06
5eeyQ-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.29A 5eeyR-4xehA:
undetectable
5eeyS-4xehA:
undetectable
5eeyR-4xehA:
14.06
5eeyS-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.32A 5eeyS-4xehA:
undetectable
5eeyT-4xehA:
undetectable
5eeyS-4xehA:
14.06
5eeyT-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 5eezB-4xehA:
undetectable
5eezC-4xehA:
undetectable
5eezB-4xehA:
14.06
5eezC-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.27A 5eezD-4xehA:
undetectable
5eezE-4xehA:
undetectable
5eezD-4xehA:
14.06
5eezE-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.32A 5eezG-4xehA:
undetectable
5eezH-4xehA:
undetectable
5eezG-4xehA:
14.06
5eezH-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.26A 5eezH-4xehA:
undetectable
5eezI-4xehA:
undetectable
5eezH-4xehA:
14.06
5eezI-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.24A 5eezJ-4xehA:
undetectable
5eezK-4xehA:
undetectable
5eezJ-4xehA:
14.06
5eezK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 5eezA-4xehA:
undetectable
5eezK-4xehA:
undetectable
5eezA-4xehA:
14.06
5eezK-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.33A 5eezN-4xehA:
undetectable
5eezO-4xehA:
undetectable
5eezN-4xehA:
14.06
5eezO-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.32A 5eezP-4xehA:
undetectable
5eezQ-4xehA:
undetectable
5eezP-4xehA:
14.06
5eezQ-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.29A 5eezR-4xehA:
undetectable
5eezS-4xehA:
undetectable
5eezR-4xehA:
14.06
5eezS-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.33A 5eezS-4xehA:
undetectable
5eezT-4xehA:
undetectable
5eezS-4xehA:
14.06
5eezT-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 5ef0B-4xehA:
undetectable
5ef0C-4xehA:
undetectable
5ef0B-4xehA:
14.06
5ef0C-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 5ef0D-4xehA:
undetectable
5ef0E-4xehA:
undetectable
5ef0D-4xehA:
14.06
5ef0E-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.33A 5ef0G-4xehA:
undetectable
5ef0H-4xehA:
undetectable
5ef0G-4xehA:
14.06
5ef0H-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.26A 5ef0H-4xehA:
undetectable
5ef0I-4xehA:
undetectable
5ef0H-4xehA:
14.06
5ef0I-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.25A 5ef0J-4xehA:
undetectable
5ef0K-4xehA:
undetectable
5ef0J-4xehA:
14.06
5ef0K-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 5ef0A-4xehA:
undetectable
5ef0K-4xehA:
undetectable
5ef0A-4xehA:
14.06
5ef0K-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.34A 5ef0N-4xehA:
undetectable
5ef0O-4xehA:
undetectable
5ef0N-4xehA:
14.06
5ef0O-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.32A 5ef0P-4xehA:
undetectable
5ef0Q-4xehA:
undetectable
5ef0P-4xehA:
14.06
5ef0Q-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.29A 5ef0R-4xehA:
undetectable
5ef0S-4xehA:
undetectable
5ef0R-4xehA:
14.06
5ef0S-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.33A 5ef0S-4xehA:
undetectable
5ef0T-4xehA:
undetectable
5ef0S-4xehA:
14.06
5ef0T-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 5ef1B-4xehA:
undetectable
5ef1C-4xehA:
undetectable
5ef1B-4xehA:
14.06
5ef1C-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.27A 5ef1D-4xehA:
undetectable
5ef1E-4xehA:
undetectable
5ef1D-4xehA:
14.06
5ef1E-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.33A 5ef1G-4xehA:
undetectable
5ef1H-4xehA:
undetectable
5ef1G-4xehA:
14.06
5ef1H-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.26A 5ef1H-4xehA:
undetectable
5ef1I-4xehA:
undetectable
5ef1H-4xehA:
14.06
5ef1I-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.25A 5ef1J-4xehA:
undetectable
5ef1K-4xehA:
undetectable
5ef1J-4xehA:
14.06
5ef1K-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 5ef1A-4xehA:
undetectable
5ef1K-4xehA:
undetectable
5ef1A-4xehA:
14.06
5ef1K-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.34A 5ef1N-4xehA:
undetectable
5ef1O-4xehA:
undetectable
5ef1N-4xehA:
14.06
5ef1O-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.33A 5ef1P-4xehA:
undetectable
5ef1Q-4xehA:
undetectable
5ef1P-4xehA:
14.06
5ef1Q-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.30A 5ef1R-4xehA:
undetectable
5ef1S-4xehA:
undetectable
5ef1R-4xehA:
14.06
5ef1S-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 5ef2B-4xehA:
undetectable
5ef2C-4xehA:
undetectable
5ef2B-4xehA:
14.06
5ef2C-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 5ef2D-4xehA:
undetectable
5ef2E-4xehA:
undetectable
5ef2D-4xehA:
14.06
5ef2E-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.33A 5ef2G-4xehA:
undetectable
5ef2H-4xehA:
undetectable
5ef2G-4xehA:
14.06
5ef2H-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.26A 5ef2H-4xehA:
undetectable
5ef2I-4xehA:
undetectable
5ef2H-4xehA:
14.06
5ef2I-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.25A 5ef2J-4xehA:
undetectable
5ef2K-4xehA:
undetectable
5ef2J-4xehA:
14.06
5ef2K-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 5ef2A-4xehA:
undetectable
5ef2K-4xehA:
undetectable
5ef2A-4xehA:
14.06
5ef2K-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.34A 5ef2N-4xehA:
undetectable
5ef2O-4xehA:
undetectable
5ef2N-4xehA:
14.06
5ef2O-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.32A 5ef2P-4xehA:
undetectable
5ef2Q-4xehA:
undetectable
5ef2P-4xehA:
14.06
5ef2Q-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.30A 5ef2R-4xehA:
undetectable
5ef2S-4xehA:
undetectable
5ef2R-4xehA:
14.06
5ef2S-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.28A 5ef3B-4xehA:
undetectable
5ef3C-4xehA:
undetectable
5ef3B-4xehA:
14.06
5ef3C-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.27A 5ef3D-4xehA:
undetectable
5ef3E-4xehA:
undetectable
5ef3D-4xehA:
14.06
5ef3E-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.34A 5ef3G-4xehA:
undetectable
5ef3H-4xehA:
undetectable
5ef3G-4xehA:
14.06
5ef3H-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.26A 5ef3H-4xehA:
undetectable
5ef3I-4xehA:
undetectable
5ef3H-4xehA:
14.06
5ef3I-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 9 THR A 188
HIS A 113
ALA A 288
HIS A 108
ILE A 116
None
1.25A 5ef3J-4xehA:
undetectable
5ef3K-4xehA:
undetectable
5ef3J-4xehA:
14.06
5ef3K-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.28A 5ef3A-4xehA:
undetectable
5ef3K-4xehA:
undetectable
5ef3A-4xehA:
14.06
5ef3K-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.34A 5ef3N-4xehA:
undetectable
5ef3O-4xehA:
undetectable
5ef3N-4xehA:
14.06
5ef3O-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.33A 5ef3P-4xehA:
undetectable
5ef3Q-4xehA:
undetectable
5ef3P-4xehA:
14.06
5ef3Q-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 10 HIS A 113
ALA A 288
HIS A 108
ILE A 116
THR A 188
None
1.30A 5ef3R-4xehA:
undetectable
5ef3S-4xehA:
undetectable
5ef3R-4xehA:
14.06
5ef3S-4xehA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
5 / 12 GLU A 181
VAL A 151
ASP A   9
ALA A 169
PRO A 130
None
1.12A 5syeB-4xehA:
2.7
5syeB-4xehA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
4 / 8 ILE A  20
ALA A  74
LEU A 104
ILE A  22
None
0.74A 5uihA-4xehA:
undetectable
5uihA-4xehA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans)
4 / 8 ASP A  38
ARG A  37
VAL A 147
GLN A  86
None
1.26A 6fbvD-4xehA:
undetectable
6fbvD-4xehA:
13.74