SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xel'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 4xel INORGANIC
PYROPHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 10 ASP A  68
PRO A  23
TYR A  52
PRO A  53
ALA A  24
 None
 1.42A 1mskA-4xelA:
undetectable		 1mskA-4xelA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 4xel INORGANIC
PYROPHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  59
GLY A  67
VAL A 170
ALA A 171
LEU A  12
 None
 1.08A 1vptA-4xelA:
undetectable		 1vptA-4xelA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4xel INORGANIC
PYROPHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  83
LEU A  73
GLY A  57
ALA A  24
ALA A  54
 None
 1.01A 3sufA-4xelA:
undetectable		 3sufA-4xelA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4xel INORGANIC
PYROPHOSPHATASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  89
ASP A  15
ARG A  87
 None
 0.63A 4wq4B-4xelA:
undetectable		 4wq4B-4xelA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4xel INORGANIC
PYROPHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 11 ASP A  68
PRO A  23
TYR A  52
PRO A  53
ALA A  24
 None
 1.46A 6bm5A-4xelA:
undetectable		 6bm5A-4xelA:
19.63