SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xeq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		3 / 3 VAL A  45
VAL A 101
TRP A 204
 None
None
PAF  A 401 (-3.7A)
 0.83A 1bdwA-4xeqA:
undetectable
1bdwB-4xeqA:
undetectable		 1bdwA-4xeqA:
5.49
1bdwB-4xeqA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		3 / 3 ASP A 129
LEU A 132
HIS A 161
 None
 0.62A 1qknA-4xeqA:
undetectable		 1qknA-4xeqA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		3 / 3 SER A 185
GLU A 219
ASP A 117
 None
 0.69A 2zthA-4xeqA:
undetectable		 2zthA-4xeqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		3 / 3 SER A 185
GLU A 219
ASP A 117
 None
 0.72A 3bwmA-4xeqA:
2.1		 3bwmA-4xeqA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		3 / 3 SER A 185
GLU A 219
ASP A 117
 None
 0.69A 3bwyA-4xeqA:
undetectable		 3bwyA-4xeqA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 7 TYR A 228
ARG A 160
ASN A 157
HIS A 247
 None
PAF  A 401 (-3.0A)
PAF  A 401 (-3.6A)
PAF  A 401 (-4.1A)
 1.41A 3frqB-4xeqA:
undetectable		 3frqB-4xeqA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 10 LEU A 116
THR A 248
THR A 103
LEU A 141
GLY A 151
 None
 1.23A 3h9uA-4xeqA:
undetectable		 3h9uA-4xeqA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 10 LEU A 116
THR A 248
THR A 103
LEU A 141
GLY A 151
 None
 1.25A 3h9uC-4xeqA:
undetectable		 3h9uC-4xeqA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 10 LEU A 116
THR A 248
THR A 103
LEU A 141
GLY A 151
 None
 1.24A 3h9uD-4xeqA:
undetectable		 3h9uD-4xeqA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		3 / 3 GLY A 203
TRP A 204
VAL A  45
 None
PAF  A 401 (-3.7A)
None
 0.60A 3n62B-4xeqA:
undetectable		 3n62B-4xeqA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		3 / 3 GLY A 203
TRP A 204
VAL A  45
 None
PAF  A 401 (-3.7A)
None
 0.58A 3n65B-4xeqA:
undetectable		 3n65B-4xeqA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		3 / 3 GLY A 203
TRP A 204
VAL A  45
 None
PAF  A 401 (-3.7A)
None
 0.60A 3n66B-4xeqA:
undetectable		 3n66B-4xeqA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 GLN A  92
GLY A 148
GLY A  94
ALA A  99
ALA A  43
 None
 1.17A 3sueB-4xeqA:
undetectable		 3sueB-4xeqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 11 GLN A  92
GLY A 148
GLY A  94
ALA A  99
ALA A  43
 None
 1.13A 3sufC-4xeqA:
undetectable		 3sufC-4xeqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 PHE A 122
LEU A 132
GLY A 104
LEU A 106
ALA A 115
 None
 1.13A 3tbgB-4xeqA:
undetectable		 3tbgB-4xeqA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 PHE A 122
LEU A 132
GLY A 104
LEU A 106
ALA A 115
 None
 1.11A 3tbgD-4xeqA:
undetectable		 3tbgD-4xeqA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 ASP A 133
ALA A 128
PHE A 122
ARG A 279
HIS A 247
 None
None
None
None
PAF  A 401 (-4.1A)
 1.41A 3wemA-4xeqA:
undetectable		 3wemA-4xeqA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 ASP A 133
ALA A 128
PHE A 122
ILE A 100
ARG A 279
 None
 1.19A 3wemA-4xeqA:
undetectable		 3wemA-4xeqA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 ASP A 133
ALA A 128
PHE A 122
ILE A 100
ARG A 279
 None
 1.20A 3weoA-4xeqA:
undetectable		 3weoA-4xeqA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 8 HIS A 188
GLU A 184
ARG A 160
ILE A 206
 None
None
PAF  A 401 (-3.0A)
None
 1.06A 4cx7A-4xeqA:
undetectable
4cx7B-4xeqA:
undetectable		 4cx7A-4xeqA:
23.11
4cx7B-4xeqA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 8 LEU A 116
SER A 245
THR A 125
ASP A 129
 None
PAF  A 401 ( 4.9A)
None
None
 1.07A 4drjB-4xeqA:
undetectable		 4drjB-4xeqA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 11 VAL A  44
THR A  41
GLU A  57
ALA A  56
HIS A  77
 None
 1.25A 4e0fA-4xeqA:
undetectable		 4e0fA-4xeqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 11 ALA A 128
ASP A 129
THR A 103
LEU A 141
ARG A 138
 None
 1.35A 4kyaA-4xeqA:
undetectable		 4kyaA-4xeqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 11 ALA A 128
ASP A 129
THR A 103
LEU A 141
ARG A 138
 None
 1.34A 4kyaG-4xeqA:
undetectable		 4kyaG-4xeqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 ALA A  37
LEU A 259
PRO A 260
LEU A 267
ILE A  40
 None
 0.89A 4m2xA-4xeqA:
undetectable		 4m2xA-4xeqA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 ALA A  37
LEU A 259
PRO A 260
LEU A 267
ILE A  40
 None
 0.93A 4m2xC-4xeqA:
undetectable		 4m2xC-4xeqA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 ALA A  37
LEU A 259
PRO A 260
LEU A 267
ILE A  40
 None
 0.93A 4m2xE-4xeqA:
undetectable		 4m2xE-4xeqA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 5 LEU A 116
ASP A 117
LEU A 140
THR A 248
 None
 1.05A 4wozF-4xeqA:
undetectable
4wozH-4xeqA:
undetectable		 4wozF-4xeqA:
21.61
4wozH-4xeqA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		3 / 3 SER A 185
GLU A 219
ASP A 117
 None
 0.71A 4xudA-4xeqA:
2.2		 4xudA-4xeqA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 5 ASP A  86
THR A  85
GLN A  89
GLU A 184
 None
 1.23A 5k9dA-4xeqA:
undetectable		 5k9dA-4xeqA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
vulgaris) 		3 / 3 GLY A 203
TRP A 204
VAL A  45
 None
PAF  A 401 (-3.7A)
None
 0.59A 5vuoB-4xeqA:
undetectable		 5vuoB-4xeqA:
23.23