SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xev'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4xev FUSION PROTEIN OF
PROTEIN-TYROSINE
KINASE 2-BETA FAT
DOMAIN AND LEUPAXIN
LD1 MOTIF
(Homo
sapiens) 		4 / 6 THR A 978
ASP A 986
ASN A 989
ASP A 992
 None
 1.31A 2okcA-4xevA:
undetectable		 2okcA-4xevA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4xev FUSION PROTEIN OF
PROTEIN-TYROSINE
KINASE 2-BETA FAT
DOMAIN AND LEUPAXIN
LD1 MOTIF
(Homo
sapiens) 		3 / 3 GLY A 914
THR A 916
ASN A 912
 None
 0.67A 3v4tD-4xevA:
undetectable		 3v4tD-4xevA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4xev FUSION PROTEIN OF
PROTEIN-TYROSINE
KINASE 2-BETA FAT
DOMAIN AND LEUPAXIN
LD1 MOTIF
(Homo
sapiens) 		5 / 11 LEU A 953
HIS A 981
LEU A 983
ALA A 979
LEU A2011
 None
 1.14A 4p65C-4xevA:
undetectable
4p65D-4xevA:
undetectable
4p65J-4xevA:
undetectable
4p65L-4xevA:
undetectable		 4p65C-4xevA:
9.28
4p65D-4xevA:
9.26
4p65J-4xevA:
9.26
4p65L-4xevA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4xev FUSION PROTEIN OF
PROTEIN-TYROSINE
KINASE 2-BETA FAT
DOMAIN AND LEUPAXIN
LD1 MOTIF
(Homo
sapiens) 		3 / 3 MET A 976
GLN A 975
ARG A 974
 None
 1.05A 5ewzB-4xevA:
3.7		 5ewzB-4xevA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4xev FUSION PROTEIN OF
PROTEIN-TYROSINE
KINASE 2-BETA FAT
DOMAIN AND LEUPAXIN
LD1 MOTIF
(Homo
sapiens) 		3 / 3 MET A 976
GLN A 975
ARG A 974
 None
 1.11A 5m35B-4xevA:
3.3		 5m35B-4xevA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4xev FUSION PROTEIN OF
PROTEIN-TYROSINE
KINASE 2-BETA FAT
DOMAIN AND LEUPAXIN
LD1 MOTIF
(Homo
sapiens) 		3 / 3 MET A 976
GLN A 975
ARG A 974
 None
 1.14A 6fn9A-4xevA:
3.1		 6fn9A-4xevA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4xev FUSION PROTEIN OF
PROTEIN-TYROSINE
KINASE 2-BETA FAT
DOMAIN AND LEUPAXIN
LD1 MOTIF
(Homo
sapiens) 		3 / 3 MET A 976
GLN A 975
ARG A 974
 None
 1.14A 6fnbA-4xevA:
3.0		 6fnbA-4xevA:
25.32